In-line ultrasound measurement system for detecting tablet integrity

International Journal of Pharmaceutics

Volumn 400, Issue 1-2, 2010, Pages 104-113

  Leskinen, Jari T T ^a   Simonaho, Simo Pekka ^a   Hakulinen, Mikko ^b   Ketolainen, Jarkko ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Compression; Defect; Speed of sound; Tablet; Ultrasound; Ultrasound attenuation

Indexed keywords

CALCIUM PHOSPHATE; LACTOSE; MICROCRYSTALLINE CELLULOSE;

ARTICLE; MATHEMATICAL MODEL; MEASUREMENT; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET DEFECT DETECTION; TABLET PROPERTY; ULTRASOUND; ULTRASOUND TRANSDUCER;

CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; QUALITY CONTROL; TABLETS; TECHNOLOGY, PHARMACEUTICAL; ULTRASONICS;

EID: 77957687860     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.08.038     Document Type: Article

References (15)

1. Akseli I., Cetinkaya C. Air-coupled non-contact mechanical property determination of drug tablets. Int. J. Pharm. 2008, 359:25-34.
2. Akseli I., Hancock B.C., Cetinkaya C. Non-destructive determination of anisotropic mechanical properties of pharmaceutical solid dosage forms. Int. J. Pharm. 2009, 377:35-44.
3. Akseli I., Becker D.C., Cetinkaya C. Ultrasonic determination of Young's moduli of the coat and core materials of a drug tablet. Int. J. Pharm. 2009, 370:17-25.
4. Akseli I., Mani G.N., Cetinkaya C. Non-destructive acoustic defect detection in drug tablets. Int. J. Pharm. 2008, 360:65-76.
5. Eriksson M., Alderborn G. The effect of particle fragmentation on the interparticulate bond formation process during powder compaction. Pharm. Res. 1995, 12:1031-1039.
6. Hakulinen M.A., Pajander J., Leskinen J., Ketolainen J., van Veen B., Niinimäki K., Pirskanen K., Poso A., Lappalainen R. Ultrasound transmission technique as a potential tool for physical evaluation of monolithic matrix tablets. AAPS PharmSciTech 2008, 9:267-273.
7. Joe Au Y.H., Eissa S., Jones B.E. Receiver operating characteristic analysis for the selection of threshold values for detection of capping in powder compression. Ultrasonics 2004, 42:149-153.
8. Ketolainen J., Oksanen M., Rantala J., Stor-Pellinen J., Luukkala M., Paronen P. Photoacoustic evaluation of elasticity and integrity of pharmaceutical tablets. Int. J. Pharm. 1995, 125:45-53.
9. Medendorp J., Lodder R.A. Acoustic-resonance spectrometry as a process analytical technology for rapid and accurate tablet identification. AAPS PharmSciTech 2006, 7:E1-E9.
10. Medendorp J.P., Fackler J.A., Douglas C.C., Lodder R.A. Integrated sensing and processing acoustic resonance spectrometry (ISP-ARS) for sample classification. J. Pharm. Innov. 2007, 2:125-134.
11. Ragozzino M. Analysis of the error in measurement of ultrasound speed in tissue due to waveform deformation by frequency-dependent attenuation. Ultrasonics 1981, 19:135-138.
12. Serris E., Perier-Camby L., Thomas G., Desfontaines M., Fantozzi G. Acoustic emission of pharmaceutical powders during compaction. Powder Technol. 2002, 128:296-299.
13. US Food and Drug Administration PAT-A Framework for Innovative Pharmaceutical Development, Manufacturing, And Quality Assurance, Guidance for Industry 2004.
14. Varghese I., Cetinkaya C. Noncontact photo-acoustic defect detection in drug tablets. J. Pharm. Sci. 2007, 96:2125-2133.
15. Waring M.J., Rubinstein M.H., Howard J.R. Acoustic emission of pharmaceutical materials during compression. Int. J. Pharm. 1987, 36:29-36.