Demyelinating symmetric motor polyneuropathy with high titers of anti-GM1 antibodies

Muscle and Nerve

Volumn 42, Issue 4, 2010, Pages 604-608

  O'Ferrall, Erin K ^a   White, Christopher M ^a   Zochodne, Douglas W ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Anti GM1; Motor neuropathy; Peripheral nerve; Polyneuropathy

Indexed keywords

AZATHIOPRINE; CREATINE KINASE; CYCLOPHOSPHAMIDE; GANGLIOSIDE GM1; GANGLIOSIDE GM1 ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN M; METHYLPREDNISOLONE; PREDNISONE; ANTIIDIOTYPIC ANTIBODY;

ACHILLES REFLEX; ADULT; ANTIBODY TITER; AREFLEXIA; ARM WEAKNESS; ARTICLE; BICEPS BRACHII MUSCLE; CASE REPORT; CREATINE KINASE BLOOD LEVEL; DEMYELINATING NEUROPATHY; DEMYELINATING SYMMETRIC MOTOR POLYNEUROPATHY; DISEASE DURATION; DRUG WITHDRAWAL; EXTENSOR MUSCLE; FINGER EXTENSOR MUSCLE; FOLLOW UP; FOOT DORSIFLEXION; FOOT EVERSION; FOOT INVERSION; FOOT PLANTARFLEXION; GAIT DISORDER; HAND MUSCLE; HEADACHE; HOSPITAL ADMISSION; HUMAN; HYPER IGM SYNDROME; IMMUNOGLOBULIN BLOOD LEVEL; INTEROSSEI MUSCLE; LEG MOVEMENT; MALE; MOTOR NEUROPATHY; MUSCLE WEAKNESS; NERVOUS SYSTEM ELECTROPHYSIOLOGY; OUTPATIENT; PATIENT COMPLIANCE; PLASMAPHERESIS; POLYCLONAL HYPERIMMUNOGLOBULIN M SYNDROME; POLYNEUROPATHY; PRIORITY JOURNAL; THUMB ABDUCTOR MUSCLE; TRICEPS BRACHII MUSCLE; WHEELCHAIR; WRIST; ACTION POTENTIAL; BLOOD; DEMYELINATING DISEASES; DISABLED PERSON; DISEASE COURSE; IMMUNOLOGY; INNERVATION; LIMB; MYELINATED NERVE; NERVE CONDUCTION; NERVE FIBER; PATHOLOGY; PATHOPHYSIOLOGY; PERONEUS NERVE; POLYNEUROPATHIES; SEVERITY OF ILLNESS INDEX; SKELETAL MUSCLE;

ACTION POTENTIALS; ADULT; ANTIBODIES, ANTI-IDIOTYPIC; AXONS; DEMYELINATING DISEASES; DISABLED PERSONS; DISEASE PROGRESSION; EXTREMITIES; G(M1) GANGLIOSIDE; HUMANS; MALE; MUSCLE, SKELETAL; NERVE FIBERS, MYELINATED; NEURAL CONDUCTION; PERONEAL NERVE; PLASMA EXCHANGE; POLYNEUROPATHIES; SEVERITY OF ILLNESS INDEX;

EID: 77957670787     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.21755     Document Type: Article

References (18)

1. Parry GJ, Clarke S. Multifocal acquired demyelinating neuropathy masquerading as motor neuron disease. Muscle Nerve 1988;11:103-107. (Pubitemid 18039607)
2. Pestronk A, Cornblath DR, Ilyas AA, Baba H, Quarles RH, Griffin JW, et al. A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. Ann Neurol 1988;24:73-78.
3. Taylor BV, Wright RA, Harper CM, Dyck PJ. Natural history of 46 patients with multifocal motor neuropathy with conduction block. Muscle Nerve 2000;23:900-908. (Pubitemid 30354497)
4. Federico P, Zochodne DW, Hahn AF, Brown WF, Feasby TE. Multifocal motor neuropathy improved by IVIg: randomized, double-blind, placebo-controlled study. Neurology 2000;55:1256-1262.
5. Pestronk A, Choksi R, Blume G, Lopate G. Multifocal motor neuropathy: serum IgM binding to a GM1 ganglioside-containing lipid mixture but not to GM1 alone. Neurology 1997;48:1104-1106.
6. Baumann N, Harpin ML, Marie Y, Lemerle K, Chassande B, Bouche P, et al. Antiglycolipid antibodies in motor neuropathies. Ann N Y Acad Sci 1998;845:322-329.
7. Nores GA, Lardone RD, Comin R, Alaniz ME, Moyano AL, Irazoqui FJ. Anti-GM1 antibodies as a model of the immune response to self-glycans. Biochim Biophys Acta 2008;1780:538-545. (Pubitemid 351391898)
8. Willison HJ, Yuki N. Peripheral neuropathies and anti-glycolipid antibodies. Brain 2002;125:2591-2625.
9. Freddo L, Yu RK, Latov N, Donofrio PD, Hays AP, Greenberg HS, et al. Gangliosides GM1 and GD1b are antigens for IgM M-protein in a patient with motor neuron disease. Neurology 1986;36:454-458. (Pubitemid 16069997)
10. Ilyas AA, Willison HJ, Quarles RH, Jungalwala FB, Cornblath DR, Trapp BD, et al. Serum antibodies to gangliosides in Guillain-Barre syndrome. Ann Neurol 1988;23:440-447.
11. Nobile-Orazio E, Gallia F, Terenghi F, Allaria S, Giannotta C, Carpo M. How useful are anti-neural IgM antibodies in the diagnosis of chronic immune-mediated neuropathies? J Neurol Sci 2008;266:156-163.
12. Taylor BV, Gross L, Windebank AJ. The sensitivity and specificity of anti-GM1 antibody testing. Neurology 1996;47:951-955.
13. Antoine JC, Camdessanche JP, Ferraud K, Caudie C. Antiganglioside antibodies in paraneoplastic peripheral neuropathies. J Neurol Neurosurg Psychiatry 2004;75:1765-1767. (Pubitemid 39611484)
14. Alpa M, Ferrero B, Cavallo R, Perna A, Naretto C, Gennaro M, et al. Anti-GM1 and anti-sulfatide antibodies in patients with systemic lupus erythematosus, Sjogren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis. Clin Exp Rheumatol 2007;25:556-562. (Pubitemid 47455464)
15. Thomas FP, Trojaborg W, Nagy C, Santoro M, Sadiq SA, Latov N, et al. Experimental autoimmune neuropathy with anti-GM1 antibodies and immunoglobulin deposits at the nodes of Ranvier. Acta Neuropathol 1991;82:378-383.
16. Takigawa T, Yasuda H, Kikkawa R, Shigeta Y, Saida T, Kitasato H. Antibodies against GM1 ganglioside affect K+ and Na+ currents in isolated rat myelinated nerve fibers. Ann Neurol 1995;37:436-442.
17. Kinsella LJ, Lange DJ, Trojaborg W, Sadiq SA, Younger DS, Latov N. Clinical and electrophysiologic correlates of elevated anti-GM1 antibody titers. Neurology 1994;44:1278-1282.
18. Chaudhry V, Corse AM, Cornblath DR, Kuncl RW, Freimer ML, Griffin JW. Multifocal motor neuropathy: electrodiagnostic features. Muscle Nerve 1994;17:198-205.