Notochordal cells influence gene expression of inflammatory mediators of annulus fibrosus cells in proinflammatory cytokines stimulation

Journal of Korean Neurosurgical Society

Volumn 48, Issue 1, 2010, Pages 1-7

  Moon, Hong Joo ^a   Joe, Hoon ^a   Kwon, Taek Hyun ^a   Choi, Hye Kyoung ^a   Park, Youn Kwan ^a   Kim, Joo Han ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Anulus fibrosus; Inflammatory mediators; Notochordal cell; Real time RT PCR

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL TISSUE; ANNULUS FIBROSUS CELL; ARTICLE; CELL CULTURE; CELL INTERACTION; CELL ISOLATION; CELL STIMULATION; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO CELL; GENE EXPRESSION; INFLAMMATION; INTERVERTEBRAL DISK; NONHUMAN; NOTOCHORD; NOTOCHORD CELL; NUCLEUS PULPOSUS; PAIN; PROTEIN EXPRESSION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 77957657981     PISSN: 20053711     EISSN: 15987876     Source Type: Journal    
DOI: 10.3340/jkns.2010.48.1.1     Document Type: Article

References (24)

1. Aguiar DJ, Johnson SL, Oegema TR: Notochordal cells interact with nucleus pulposus cells: regulation of proteoglycan synthesis. Exp Cell Res 246: 129-137, 1999
2. Baer AE, Wang JY, Kraus VB, Setton LA: Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures. J Orthop Res 19: 2-10, 2001
3. Biyani A, Andersson GB: Low back pain: pathophysiology and management. J Am Acad Orthop Surg 12: 106-115, 2004
4. Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF, Nerlich AG: Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine (Phila Pa 1976) 27: 2631-2644, 2002
5. Burke JG, Watson RW, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM: Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 84: 196-201, 2002
6. Erwin WM, Ashman K, O'Donnel P, Inman R: Nucleus pulposus notochord cells secrete connective tissue growth factor and up-regulate proteoglycan expression by intervertebral disc chondrocytes. Arthritis Rheum 54: 3859-3867, 2006
7. Erwin WM, Inman RD: Notochord cells regulate intervertebral disc chondrocyte proteoglycan production and cell proliferation. Spine (Phila Pa 1976) 31: 1094-1099, 2006
8. Ghosh P, Taylor TK, Braund KG: The variation of the glycosaminoglycans of the canine intervertebral disc with ageing. I. Chondrodystrophoid breed. Gerontology 23: 87-98, 1977
9. Humzah MD, Soames RW: Human intervertebral disc: structure and function. Anat Rec 220: 337-356, 1988
10. Kang JD, Georgescu HI, McIntyre-Larkin L, Stefanovic-Racic M, Donaldson WF 3rd, Evans CH: Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin- 6, and prostaglandin E2. Spine (Phila Pa 1976) 21: 271-277, 1996
11. Kim JH, Studer RK, Sowa GA, Vo NV, Kang JD: Activated macrophage- like THP-1 cells modulate anulus fibrosus cell production of inflammatory mediators in response to cytokines. Spine (Phila Pa 1976) 33: 2253-2259, 2008
12. Kim JH, Studer RK, Vo NV, Sowa GA, Kang JD: p38 MAPK inhibition selectively mitigates inflammatory mediators and VEGF production in AF cells co-cultured with activated macrophage-like THP-1 cells. Osteoarthritis Cartilage 17: 1662-1669, 2009
13. Masuda K, Miyabayashi T, Meachum SH, Eurell TE: Proliferation of canine intervertebral disk chondrocytes in three-dimensional alginate microsphere culture. J Vet Med Sci 64: 79-82, 2002
14. Minami T, Okuda-Ashitaka E, Hori Y, Sakuma S, Sugimoto T, Sakimura K, et al.: Involvement of primary afferent C-fibres in touchevoked pain (allodynia) induced by prostaglandin E2. Eur J Neurosci 11: 1849-1856, 1999
15. Namkoong S, Lee SJ, Kim CK, Kim YM, Chung HT, Lee H, et al.: Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/ cGMP pathway in human umbilical vein endothelial cells. Exp Mol Med 37: 588-600, 2005
16. Okuma M, Mochida J, Nishimura K, Sakabe K, Seiki K: Reinsertion of stimulated nucleus pulposus cells retards intervertebral disc degeneration: an in vitro and in vivo experimental study. J Orthop Res 18: 988-997, 2000
17. Peng B, Hao J, Hou S, Wu W, Jiang D, Fu X, et al.: Possible pathogenesis of painful intervertebral disc degeneration. Spine (Phila Pa 1976) 31: 560-566, 2006
18. Rand N, Reichert F, Floman Y, Rotshenker S: Murine nucleus pulposus- derived cells secrete interleukins-1-beta, -6, and -10 and granulocyte- macrophage colony-stimulating factor in cell culture. Spine 22: 2598-2601; discussion 2602, 1997
19. Stevens JW, Kurriger GL, Carter AS, Maynard JA: CD44 expression in the developing and growing rat intervertebral disc. Dev Dyn 219: 381-390, 2000
20. Takahashi H, Suguro T, Okazima Y, Motegi M, Okada Y, Kakiuchi T: Inflammatory cytokines in the herniated disc of the lumbar spine. Spine (Phila Pa 1976) 21: 218-224, 1996
21. Urban JP, Roberts S: Development and degeneration of the intervertebral discs. Mol Med Today 1: 329-335, 1995
22. Walmsley R: The development and growth of the intervertebral disc. Edinb Med J 60: 341-364, 1953
23. Weiler C, Nerlich AG, Bachmeier BE, Boos N: Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine (Phila Pa 1976) 30: 44-53; discussion 54, 2005
24. Yoshida M, Nakamura T, Sei A, Kikuchi T, Takagi K, Matsukawa A: Intervertebral disc cells produce tumor necrosis factor alpha, interleukin- 1beta, and monocyte chemoattractant protein-1 immediately after herniation: an experimental study using a new hernia model. Spine (Phila Pa 1976) 30: 55-61, 2005