Metabolic predictors for early identification of fatty liver using doppler and B-mode ultrasonography in overweight and obese adolescents

European Journal of Pediatrics

Volumn 169, Issue 11, 2010, Pages 1345-1352

  Ozkol, Mine ^a   Ersoy, Betül ^a   Kasirga, Erhun ^a   Taneli, Fatma ^a   Bostanci, Işil Esen ^a   Ozhan, Bayram ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Children; Fatty liver; HDL C; Obesity; Ultrasonography

Indexed keywords

ADIPONECTIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID;

ADOLESCENT; ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; CHILD; DOPPLER ECHOCARDIOGRAPHY; FATTY LIVER; FEMALE; GROUPS BY AGE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; OBESITY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; CHILD; CHOLESTEROL, HDL; DISEASE PROGRESSION; EARLY DIAGNOSIS; FATTY LIVER; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; OBESITY; OVERWEIGHT; PROGNOSIS; RISK FACTORS; ULTRASONOGRAPHY, DOPPLER;

EID: 77957654443     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-010-1227-2     Document Type: Article

References (40)

1. P Angulo 2002 Non-alcoholic fatty liver disease N Engl J Med 346 1221 1231 1:CAS:528:DC%2BD38XivVOmsrY%3D 10.1056/NEJMra011775 11961152
2. NJ Barshop CB Sirlin JB Schwimmer JE Lavine 2008 Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease Aliment Pharmacol Ther 28 13 24 1:CAS:528: DC%2BD1cXovFelsbo%3D 10.1111/j.1365-2036.2008.03703.x 18397387
3. A Böttner J Kratzsch G Müller, et al. 2004 Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels J Clin Endocrinol Metab 89 8 4053 4061 10.1210/jc.2004-0303 15292348
4. TS Burgert SE Taksali J Dziura, et al. 2006 Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat J Clin Endocrinol Metab 91 4287 4294 1:CAS:528:DC%2BD28Xht1Whur3M 10.1210/jc.2006-1010 16912127
5. DF Chan AM Li WC Chu, et al. 2004 Hepatic steatosis in obese Chinese children Int J Obes Relat Metab Disord 28 1257 1263 1:STN:280: DC%2BD2cvls1WmsA%3D%3D 10.1038/sj.ijo.0802734 15278103
6. TJ Cole MC Bellizzi KM Flegal WH Dietz 2000 Establishing a standard definition for child overweight and obesity worldwide: international survey Br Med J 320 1240 1243 1:STN:280:DC%2BD3c3lvFehsA%3D%3D 10.1136/bmj.320.7244.1240
7. AR Damaso WL do Prado A de Piano, et al. 2008 Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents Dig Liver Dis 40 2 132 139 1:CAS:528:DC%2BD1cXjvF2itLo%3D 10.1016/j.dld.2007.09.009 18082476
8. A de Piano WL Prado DA Caranti, et al. 2007 Metabolic and nutritional profile of obese adolescents with nonalcoholic fatty liver disease J Pediatr Gastroenterol Nutr 44 446 452 10.1097/MPG.0b013e31803815d9 17414142
9. A de Piano L Tock J Carnier, et al. 2009 Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy Metabolism 59 5 613 619 10.1016/j.metabol.2009.09.003 19942238
10. A Franzese P Vajro A Argenziano, et al. 1997 Liver involvement in obese children: ultrasonography and liver enzyme levels at diagnosis and during follow-up on an Italian population Dig Dis Sci 42 1428 1432 1:STN:280: DyaK2szovVyjug%3D%3D 10.1023/A:1018850223495 9246041
11. A Fraser MP Longnecker DA Lawlor 2007 Prevalence of elevated alanine-aminotransferase (ALT) among US adolescents and associated factors: NHANES 1999-2004 Gastroenterology 133 1814 1820 1:CAS:528:DC%2BD1cXnt1Kqsw%3D%3D 10.1053/j.gastro.2007.08.077 18054554
12. WT Friedwald RI Levy DS Frederickson 1972 Estimation of the concentration of low-density lipoprotein in plasma, without use of the preparative ultracentrifuge Clin Chem 18 499 502
13. PM Gholam L Flancbaum JT Machan, et al. 2007 Nonalcoholic fatty liver disease in severely obese subjects Am J Gastroenterol 102 2 399 408 1:CAS:528:DC%2BD2sXivF2ksb0%3D 10.1111/j.1572-0241.2006.01041.x 17311652
14. N Karabulut S Kazil B Yagci N Sabir 2004 Doppler waveform of the hepatic veins in an obese population Eur Radiol 14 2268 2272 10.1007/s00330-004-2423-0 15599548
15. M Keskin S Kurtoglu M Kendirci, et al. 2005 Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents Pediatrics 115 e500 e503 10.1542/peds.2004-1921 15741351
16. A Kettaneh B Heude JM Oppert, et al. 2006 Serum adiponectin is related to plasma high-density lipoprotein cholesterol but not to plasma insulin-concentration in healthy children: the FLVS II study Metabolism 55 1171 1176 1:CAS:528:DC%2BD28XotlCisbc%3D 10.1016/j.metabol.2006.04.015 16919535
17. R Loomba CB Sirlin JB Schwimmer JE Lavine 2009 Advances in pediatric nonalcoholic fatty liver disease Hepatology 50 1282 1293 1:CAS:528: DC%2BD1MXhtlWksr7F 10.1002/hep.23119 19637286
18. MV Louthan S Barve CS McClain S Joshi-Barve 2005 Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease J Pediatr 147 835 838 1:CAS:528:DC%2BD2MXhtlWqu73K 10.1016/j.jpeds.2005.07.030 16356442
19. CA Matteoni ZM Younossi T Gramlich N Boparai YC Liu AJ McCullough, et al. 1999 Non-alcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 116 1413 1419 1:STN:280:DyaK1M3nvVamtw%3D%3D 10.1016/S0016-5085(99)70506-8 10348825
20. DR Mager S Ling EA Roberts 2008 Anthropometric and metabolic characteristics in children with clinically diagnosed nonalcoholic fatty liver disease Peadiatr Child Health 13 111 117
21. WA Marshall JM Tanner 1970 Variations in the pattern of pubertal changes in boys Arch Dis Child 45 13 23 1:STN:280:DyaE3c7msVGrsQ%3D%3D 10.1136/adc.45.239.13 5440182
22. L Oguzkurt T Yildirim D Torun, et al. 2005 Hepatic vein Doppler waveform in patients with diffuse fatty infiltration of the liver Eur J Radiol 54 253 257 10.1016/j.ejrad.2004.05.011 15837406
23. AM Oliveira N Oliveira JC Reis, et al. 2009 Triglycerides and alanine aminotransferase as screening markers for suspected fatty liver disease in obese children and adolescents Horm Res 71 83 88 1:CAS:528:DC%2BD1MXisFGntLg%3D 10.1159/000183896 19129712
24. P Panagopoulou A Galli-Tsinopoulou A Fleva, et al. 2008 Adiponectin and insulin resistance in childhood obesity J Pediatr Gastroenterol Nutr 47 356 362 1:CAS:528:DC%2BD1cXhtVejsbrF 10.1097/MPG.0b013e31817fcb67 18728534
25. D Papandreou I Rousso P Malindretos, et al. 2008 Are saturated fatty acid and insulin resistance associated with fatty liver in obese children? Clin Nutr 27 233 240 1:CAS:528:DC%2BD1cXksVans7Y%3D 10.1016/j.clnu.2007.11.003 18234396
26. R Posadas-Sanchez C Posadas-Romero J Zamora-Gonzales, et al. 2007 Lipid and lipoprotein profiles and prevalence of dyslipidemia in Mexican adolescents Metabolism 56 1666 1672 1:CAS:528:DC%2BD2sXht1yktb7M 10.1016/j.metabol.2007.07. 009 17998019
27. C Pozzato G Radaelli C Dall'Asta, et al. 2008 MRI in identifying hepatic steatosis in obese children and relation to ultrasonography and metabolic findings J Pediatr Gastroenterol Nutr 47 493 499 10.1097/MPG.0b013e31817b6e10 18852643
28. S Saadeh ZM Younossi EM Remer, et al. 2002 The utility of radiological imaging in nonalcoholic fatty liver disease Gastroenterology 123 745 50 10.1053/gast.2002.35354 12198701
29. R Sagi S Reif G Neuman, et al. 2007 Nonalcoholic fatty liver disease in overweight children and adolescents Acta Pediatr 96 1209 1213 1:STN:280:DC%2BD2svjvVSmtw%3D%3D 10.1111/j.1651-2227.2007.00399.x
30. A Sartorio A Del Cole F Agosti, et al. 2007 Predictors of non-alcoholic fatty liver disease in obese children Eur J Clin Nutr 61 7 877 83 1:CAS:528:DC%2BD2sXnt1WlsLg%3D 10.1038/sj.ejcn.1602588 17151586
31. JB Schwimmer N McGreal R Deutsch, et al. 2005 Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents Pediatrics 115 5 e561 e565 10.1542/peds.2004-1832 15867021
32. H Uzun B Yazici B Erdogmus, et al. 2009 Doppler waveforms of the hepatic veins in children with diffuse fatty infiltration of the liver Eur J Radiol 71 552 556 10.1016/j.ejrad.2008.06.004 18824318
33. M van Vliet IA von Rosenstiel RK Schindhelm, et al. 2009 The association of elevated alanine aminotransferase and the metabolic syndrome in an overweight and obese pediatric population of multi-ethnic origin Eur J Pediatr 168 5 585 591 10.1007/s00431-008-0802-2 18696112
34. NK Vikram A Misra RM Pandey, et al. 2004 Adiponectin, insulin resistance, and C-reactive protein in postpubertal Asian Indian adolescents Metabolism 53 1336 1341 1:CAS:528:DC%2BD2cXnslehsbg%3D 10.1016/j.metabol.2004.05.010 15375791
35. B Vozarova N Stefan RS Lindsay, et al. 2002 High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes Diabetes 51 1889 1895 1:CAS:528: DC%2BD38XktlSktb0%3D 10.2337/diabetes.51.6.1889 12031978
36. JC Winer TL Zern SE Taksali, et al. 2006 Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome J Clin Endocrinol Metab 91 11 4415 4423 1:CAS:528:DC%2BD28Xht1WhurrL 10.1210/jc.2006-0733 16926246
37. Y Yajima K Ohta T Narui, et al. 1983 Ultrasonographical diagnosis of fatty liver: significance of the liver-kidney contrast Tohoku J Exp Med 139 43 50 1:STN:280:DyaL3s7nt1Cqtg%3D%3D 10.1620/tjem.139.43 6220488
38. J Yoo S Lee K Kim, et al. 2008 Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children Diabetes Res Clin Pract 81 321 326 1:CAS:528:DC%2BD1cXhtVWitLfO 10.1016/j.diabres.2008.05.006 18571268
39. Young DS (1997) Effects of preanalytical variables on clinical laboratory tests. American Association for Clinical Chemistry, Washington
40. CC Zou L Liang F Hong, et al. 2005 Serum adiponectin, resistin levels and non-alcoholic fatty liver disease in obese children Endocr J 52 5 519 524 1:CAS:528:DC%2BD28Xjs1Cgsg%3D%3D 10.1507/endocrj.52.519 16284427