Epithelial plasticity, stemness and pluripotency

Cell Research

Volumn 20, Issue 10, 2010, Pages 1086-1088

  Ocãa, Oscar H ^a   Nieto, M Angela ^a  

^a INSTITUTO DE NEUROCIENCIAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BMP7 PROTEIN, HUMAN; MICRORNA; MIRN200 MICRORNA, HUMAN; OCTAMER TRANSCRIPTION FACTOR 4; OSTEOGENIC PROTEIN 1; POU5F1 PROTEIN, HUMAN; SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

ARTICLE; CANCER STEM CELL; CYTOLOGY; EPITHELIUM CELL; FIBROBLAST; HUMAN; MESODERM; METABOLISM; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL;

BONE MORPHOGENETIC PROTEIN 7; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MESODERM; MICRORNAS; NEOPLASTIC STEM CELLS; NUCLEAR REPROGRAMMING; OCTAMER TRANSCRIPTION FACTOR-3; SOXB1 TRANSCRIPTION FACTORS;

EID: 77957607058     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.127     Document Type: Article

References (14)

1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fbroblast cultures by defned factors. Cell 2006; 126:663-676.
2. Li R, Liang J, Ni S, et al. A mesenchy-mal-to-epithelial transition initiates and is required for the nuclear reprogram-ming of mouse fbroblasts. Cell Stem Cell 2010; 7:51-63.
3. Samavarchi-Tehrani P, Golipour A, David L, et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 2010; 7:64-77.
4. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-890.
5. Ichida JK, Blanchard J, Lam K, et al. A small-molecule inhibitor of tgf-β signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 2009; 5:491-503.
6. Maherali N, Hochedlinger K. Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Curr Biol 2009; 19:1718-1723.
7. Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003; 9:964-968.
8. Ocaña OH, Nieto MA. A new regulatory loop in cancer cell invasion. EMBO Rep 2008; 9:521-522.
9. Silva J, Nichols J, Theunissen TW, et al. Nanog is the gateway to the pluripo-tent ground state. Cell 2009; 138:722-737.
10. Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133:704-715.
11. Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. Generation of breast cancer stem cells through ep-ithelial-mesenchymal transition. PLoS One 2008; 3:e2888.
12. Gupta PB, Chaffer CL, Weinberg RA. Cancer stem cells: Mirage or reality? Nat Med 2009; 15:1010-1012.
13. Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9:265-273.
14. Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat Rev Cancer 2005; 5:744-749.