Diphenyl diselenide-induced seizures in rat pups: Possible interaction with GABAergic system

Neurological Research

Volumn 32, Issue 9, 2010, Pages 1002-1008

  Prigol, Marina ^a   Wilhelm, Ethel A ^a   Nogueira, Cristina W ^a   Zeni, Gilson ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Diphenyl diselenide; GABA; Pups; Seizures; Selenium

Indexed keywords

2,4 DIAMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID; AMINOOXYACETIC ACID; DIAZEPAM; DIPHENYL DISELENIDE; PHENOBARBITAL; PICROTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CONTROLLED STUDY; CONVULSION; DRUG EFFECT; FEMALE; GABAERGIC SYSTEM; HIPPOCAMPUS; LATENT PERIOD; MALE; NONHUMAN; RAT; SEIZURE; TREATMENT RESPONSE;

ACETANILIDES; ANIMALS; ANIMALS, NEWBORN; BENZENE DERIVATIVES; DIAZEPAM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; ORGANOSELENIUM COMPOUNDS; PHENOBARBITAL; PICROTOXIN; RATS; SEIZURES;

EID: 77957598902     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164110X12670144737738     Document Type: Article

References (37)

1. Mcnamara JO. Emerging insights into the genesis of epilepsy. Nature. 1999; 399: A15-A22.
2. Lothman EW, Bertram EH, Stringer JL. Functional anatomy ofhippocampal seizures. Prog Neurobiol. 1991; 37: 1-82.
3. Holmes GL, Gairsa JL, Chevassus-Au-louis N, Ben-Ari Y. Consequences of neonatal seizures in the rat: morphological and behavioral effects. Ann Neurol. 1998; 44: 845-57.
4. Zupanc ML. Neonatal seizures. Pediatr Clin N Am. 2004; 51: 961-78.
5. Wasterlain CG, Niquet J, Thompson KW, Baldwin R, Liu H, Sankar R, et al. Seizure-induced neuronal death in the immature brain. Prog Brain Res. 2002; 135: 335-53.
6. Yu X, Shao XG, Sun H, Li YN, Yang J, Deng YC, et al. Activation of cerebral peroxisome proliferator-activated recep-tors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus. Brain Res. 2008; 1200: 146-58.
7. Mueller-Burke D, Koehler RC, Martin LJ. Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia. Int J Dev Neurosci. 2008; 26: 67-76.
8. Savegnago L, Jesse CR, Pinto LG, Rocha JBT, Nogueira CW. Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice. Brain Res. 2007; 1175: 54-59.
9. Savegnago L, Pinto LG, Jesse CR, Alves D, Rocha JB, Nogueira CW, et al. Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action. Eur J Pharmacol. 2007; 555: 129-38.
10. Savegnago L, Pinto LG, Jesse CR, Rocha JB, Nogueira CW, Zeni G. Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31: 1261-69.
11. Prigol M, Wilhelm EA, Schneider CC, Rocha JB, Nogueira CW, Zeni G. Involvement of oxidative stress in seizures induced by diphenyl diselenide in rat Pups. Brain Res. 2007; 1147: 226-32.
12. Prigol M, Wilhelm EA, Stangherlin EC, Barancelli DA, Nogueira CW, Zeni G. Diphenyl diselenide-induced seizures in rat pups: possible interaction with glutamatergic system. Neurochem Res. 2008; 33: 996-1004.
13. Grunewald R. Childhood seizures and their consequences for the hippocampus. Brain. 2002; 125: 1935-36.
14. Meldrum BS. Concept of activity-induced cell death in epilepsy: historical and contemporany perspectives. Prog Brain Res. 2002; 135: 3-11.
15. Chaudhry FA, Reimer RJ, Bellocchio EE, Danbolt NC, Osen KK, Edwards RH, et al. The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons. J Neurosci. 1998; 18: 9733-50.
16. Amabeoku G, Chikuni O, Bwakura E. Gamma aminobutyric acid mediation of the anticonvulsivant effect of clonidine on pentylenetetrazol-induced seizures in mice. Pharmacol Res. 1994; 29: 273-80.
17. A receptor pharmacology. Pharmacol Ther. 1996; 69: 173-98.
18. Paulmier C. Selenoorganic functional groups. In: Paulmier, C. (ed.). Selenium reagents and intermediates in organic synthesis, 1st ed. Oxford: Pergamon Press; 1986. pp. 25-51.
19. Racine RJ. Modification of seizures activity by electrical stimulation: II. Motor seizure Electroencephalogr. Clin Neurophysiol. 1972; 32: 281-94.
20. Sperk GH, Lassmamm H, Baran H, Seitelberger F, Hornykiewicz O. Kainic acid-inducet seizures: dose-relation-ship of behavioural, neurochemical amd histopathological changes. Brain Res. 1985; 338: 289-95.
21. Schweigerta ID, de Oliveira DL, Scheibela F, da Costa F, Wofchuk ST, Souza DO, et al. Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippo-campal slices. Brain Res Dev Brain Res. 2005; 154: 177-85.
22. Bradford MM. A rapid and sensitive method for the quantifica-tion of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem. 1976; 72: 248-54.
23. A receptor phosphorylation: multiple sites, actions and artifacts. Trends Pharmacol Sci. 1991; 12: 84-87.
24. Prigol M, Schumacher RF, Nogueira CW. Convulsant effect of diphenyl diselenide in rats and mice and its relationship to plasma levels. Toxicol Lett. 2009; 189: 35-39.
25. Brito VB, Rocha JB, Folmer V, Erthal F. Diphenyl diselenide and diphenyl ditelluride increase the latency for 4-aminopyr-idine-induced chemical seizure and prevent death in mice. Acta Biochim Pol. 2009; 56: 125-34.
26. Meldrum BS. Why and when are seizures bad for de brain? Trend Pharmacol Sci. 2001; 22: 445-46.
27. Gale K. Role of GABA in the genesis of chemoconvulsant seizures. Toxicol Lett. 1992; 64: 417-28.
28. Nogueira CW, Meotti FC, Curte E, Pilissão C, Zeni G, Rocha JB. Investigations into the potential neurotoxicity induced by diselenides in mice and rats. Toxicology. 2003; 183: 29-37.
29. Chaudhry FA, Reimer RJ, Bellocchio EE, Danbolt NC, Osen KK, Edwards RH, et al. The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons. J Neurosci. 1998; 18: 9733-50.
30. Brito VB, Folmer V, Puntel GO, Fachinetto R, Soares JC, Zeni G, et al. Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice. Brain Res Bull. 2006; 68: 414-18.
31. Newland CF, Cull-Candy SG. On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympa-thetic neurones of the rat. J Physiol. 1992; 447: 191-213.
32. Gadea A, Lopez-Colome AM. Glial transporters for glutamate, glycine, and GABA: II. GABA transporters, J Neurosci Res. 2001; 63: 461-68.
33. Devaud LL. Ethanol dependence has limited effects on GABA or glutamate transporters in rat brain. Alcohol Clin Exp Res. 2001; 25: 606-11.
34. Löscher W, Ebert U. Basic mechanisms of seizure propagation: targets for rational drug design and rational polypharmacy. Epilepsy Res Suppl. 1996; 11: 17-44.
35. Meyer DA, Carter JM, Johnstone AF. Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture, Neurotoxicology. 2008; 29: 213-25.
36. Yu ZY, Wang W, Fritschy JM, Witte OW, Redecker C. Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging. Brain Res. 2006; 1999: 73-81.
37. Sabau H, Frahm C, Pfeiffer M, Breustedt JM, Piechotta A, Numberger M, et al. Age-dependence of the anticonvulsant effects of the GABA uptake inhibitor tiagabine in vitro. Eur J Pharmacol. 1999; 383: 259-66.