Findings in genome-wide association studies on asthma lack generalisation

Clinical Respiratory Journal

Volumn 4, Issue 4, 2010, Pages

  Zhang, Guicheng ^a   Goldblatt, Jack ^a   LeSouëf, Peter ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1B ADRENERGIC RECEPTOR; DIPEPTIDYL PEPTIDASE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18 RECEPTOR; PRION PROTEIN; TRANSDUCIN; TRANSFORMING GROWTH FACTOR BETA;

ASTHMA; ENVIRONMENTAL FACTOR; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HEREDITY; HUMAN; LETTER; MULTIFACTORIAL INHERITANCE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ASTHMA; GENOME-WIDE ASSOCIATION STUDY; HUMANS;

EID: 77957580770     PISSN: 17526981     EISSN: 1752699X     Source Type: Journal    
DOI: 10.1111/j.1752-699X.2010.00213.x     Document Type: Letter

References (13)

1. Zhang G, Goldblatt J, LeSouef P. The era of genome-wide association studies: opportunities and challenges for asthma genetics. J Hum Genet. 2009 54 (11 624 8.
2. Hancock DB, Romieu I, Shi M, et al. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in Mexican children. PLoS Genet. 2009 5 (8 e1000623.
3. Mathias RA, Grant AV, Rafaels N, et al. A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol. 2010 125 (2 336 46.
4. Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007 448 (7152 470 3.
5. Choudhry S, Taub M, Mei R, Rodriguez-Santana J, Rodriguez-Cintron W, Shriver MD, Ziv E, Risch NJ, Burchard EG. Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region. Hum Genet. 2008 123 (5 455 68.
6. Himes BE, Hunninghake GM, Baurley JW, et al. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet. 2009 84 (5 581 93.
7. Wu H, Romieu I, Shi M, Hancock DB, Li H, Sienra-Monge JJ, Chiu GY, Xu H, Estela Del Rio-Navarro B, London SJ. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. J Allergy Clin Immunol. 2010 125 (2 321 7.
8. Rogers AJ, Raby BA, Lasky-Su JA, et al. Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med. 2009 179 (12 1084 90.
9. Zhang G, Goldblatt J, LeSouef PN. Does the relationship between IgE and the CD14 gene depend on ethnicity? Allergy. 2008 63 (11 1411 7.
10. Zhang G, Khoo SK, Laatikainen T, et al. Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy. Allergy. 2009 64 (9 1333 41.
11. Candelaria PV, Backer V, Khoo SK, et al. The importance of environment on respiratory genotype/phenotype relationships in the Inuit. Allergy. 2010 65 (2 229 37.
12. Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet. 2008 372 (9643 1107 19.
13. Thomas D. Gene-environment-wide association studies: emerging approaches. Nat Rev Genet. 2010 11 (4 259 72.