Synthesis and evaluation of original amidoximes as antileishmanial agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 20, 2010, Pages 7310-7320

  Bouhlel, Ahlem ^a   Curti, Christophe ^a   Dumtre, Aurélien ^a   Laget, Michle ^a   Crozet, Maxime D ^a   Azas, Nadine ^a   Vanelle, Patrice ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Amidoximes; Antileishmanial; Dihydrofuran

Indexed keywords

2 [4 (5 BENZYL 2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 5 METHYL 4,5 DIHYDROFURAN 3 YLSULFONYL) PHENYLAMINO] N' HYDROXYBENZIMIDAMIDE; 2 [4 (5 BENZYL 3 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYLSULFONYL) 5 METHYL 4,5 DIHYDROFURAN 2 YL) PHENYLAMINO] N' HYDROXYBENZIMIDAMIDE; 3 [4 (5 BENZYL 2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 5 METHYL 4,5 DIHYDROFURAN 3 YLSULFONYL) PHENYLAMINO] N' HYDROXYBENZIMIDAMIDE; 3 [4 (5 BENZYL 3 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYLSULFONYL) 5 METHYL 4,5 DIHYDROFURAN 2 YL) PHENYLAMINO] N'HYDROXYBENZIMIDAMIDE; 4 (5 BENZYL 5 METHYL 2 PHENYL 4,5 DIHYDROFURAN 3 YLSULFONYL) N' HYDROXYBENZIMIDAMIDE; 4 [4 (5 BENZYL 2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 5 METHYL 4,5 DIHYDROFURAN 3 YLSULFONYL) PHENYLAMINO] N' HYDROXYBENZIMIDAMIDE; 4 [4 (5 BENZYL 2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 5 METHYL 4,5 DIHYDROFURAN 3 YLSULFONYL) STYRYL] N' HYDROXYBENZIMIDAMIDE; 4 [5 BENZYL 2 (4 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYLAMINO) PHENYL) 5 METHYL 4,5 DIHYDROFURAN 3 YLSULFONYL] N' HYDROXYBENZIMIDAMIDE; 4 [5 BENZYL 2 (4 (4 (N' HYDROXYCARBAMIMIDOYL) STYRYL) PHENYL) 5 METHYL 4,5 DIHYDROFURAN 3 YLSULFONYL] N' HYDROXYBENZIMIDAMIDE; 4 [5 BENZYL 2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 5 METHYL 4,5 DIHYDROFURAN 3 YLSULFONYL] N' HYDROXYBENZIMIDAMIDE; 4 [5 BENZYL 5 METHYL 3 (PHENYLSULFONYL) 4,5 DIHYDROFURAN 2 YL] N' HYDROXYBENZIMIDAMIDE; 4 [5,5 DIPHENYL 3 (PHENYLSULFONYL) 4,5 DIHYDROFURAN 2 YL] N' HYDROXYBENZIMIDAMIDE; AMIDOXIME DERIVATIVE; ANTILEISHMANIAL AGENT; MANGANESE; N HYDROXY 4 [4 (3 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYLSULFONYL) 5,5 DIPHENYL 4,5 DIHYDROFURAN 2 YL) STYRYL] BENZIMIDAMIDE; N' HYDROXY 2 [4 (2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 5,5 DIPHENYL 4,5 DIHYDROFURAN 3 YLSULFONYL) PHENYLAMINO] BENZIMIDAMIDE; N' HYDROXY 2 [4 (3 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYLSULFONYL) 5,5 DIPHENYL 4,5 DIHYDROFURAN 2 YL) PHENYLAMINO] BENZIMIDAMIDE; N' HYDROXY 3 [4 (2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 5,5 DIPHENYL 4,5 DIHYDROFURAN 3 YLSULFONYL) PHENYLAMINO] BENZIMIDAMIDE; N' HYDROXY 3 [4 (3 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYLSULFONYL) 5,5 DIPHENYL 4,5 DIHYDROFURAN 2 YL) PHENYLAMINO] BENZIMIDAMIDE; N' HYDROXY 4 (2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 2 OXOETHYLSULFONYL] BENZIMIDAMIDE; N' HYDROXY 4 (2 OXO 2 PHENYLETHYLSULFONYL) BENZIMIDAMIDE; N' HYDROXY 4 (2,5,5 TRIPHENYL 4,5 DIHYDROFURAN 3 YLSULFONYL) BENZIMIDAMIDE; N' HYDROXY 4 [2 (4 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYLAMINO) PHENYL) 5,5 DIPHENYL 4,5 DIHYDROFURAN 3 YLSULFONYL] BENZIMIDAMIDE; N' HYDROXY 4 [2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 5,5 DIPHENYL 4,5 DIHYDROFURAN 3 YLSULFONYL] BENZIMIDAMIDE; N' HYDROXY 4 [2 (PHENYLSULFONYL) ACETYL] BENZIMIDAMIDE; N' HYDROXY 4 [4 (2 (4 (N HYDROXYCARBAMIMIDOYL) PHENYL) 5,5 DIPHENYL 4,5 DIHYDROFURAN 3 YLSULFONYL) STYRYL] BENZIMIDAMIDE; N' HYDROXY 4 [4 (2 (4 (N' HYDROXYCARBAMIMIDOYL) PHENYL) 5,5 DIPHENYL 4,5 DIHYDROFURAN 3 YLSULFONYL) PHENYLAMINO] BENZIMIDAMIDE; PENTAMIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTILEISHMANIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HECK REACTION; HUMAN; HUMAN CELL; LEISHMANIA DONOVANI; PROMASTIGOTE;

ANTIPROTOZOAL AGENTS; CELL LINE; CYCLIZATION; HUMANS; LEISHMANIA DONOVANI; MANGANESE; OXIDATION-REDUCTION; OXIMES; STRUCTURE-ACTIVITY RELATIONSHIP;

LEISHMANIA DONOVANI;

EID: 77957576739     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.099     Document Type: Article

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