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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5781-5786

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase

(5) De Schutter, Joris W a Zaretsky, Serge a Welbourn, Sarah a Pause, Arnim a Tsantrizos, Youla S a

a MCGILL UNIVERSITY (Canada)

Author keywords

Bisphosphonates; Human FPPS

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; GERANYLGERANYL PYROPHOSPHATE; ISOPENTENYL DIPHOSPHATE;

ARTICLE; DRUG BINDING; DRUG ISOLATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COMPUTER SIMULATION; DIPHOSPHONATES; ENZYME INHIBITORS; ETIDRONIC ACID; GERANYLGERANYL-DIPHOSPHATE GERANYLGERANYLTRANSFERASE; HEMITERPENES; HUMANS; ORGANOPHOSPHORUS COMPOUNDS; POLYISOPRENYL PHOSPHATES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957561567 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.07.133 Document Type: Article

Times cited : (14)

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