Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease

Journal of Gastroenterology and Hepatology (Australia)

Volumn 25, Issue 10, 2010, Pages 1626-1630

  Ohtsuka, Yoshikazu ^a   Arai, Katsuhiro ^b   Aoyagi, Yo ^a   Fujii, Tohru ^a   Yamakawa, Yoko ^a   Ohtani, Kiyotaka ^a   Ikuse, Tamaki ^a   Baba, Yosuke ^a   Inage, Eisuke ^a   Kudo, Takahiro ^a   Suzuki, Ryuyo ^a   Nagata, Satoru ^a   Shimizu, Toshiaki ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

6 mercaptopurine; adolescent; azathioprine; children; Crohn's disease; ulcerative colitis

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; MERCAPTOPURINE; MESALAZINE; TIOGUANINE; 6 THIOGUANINE NUCLEOTIDE; ALANINE AMINOTRANSFERASE; AMYLASE; DRUG METABOLITE; PREDNISOLONE; UNCLASSIFIED DRUG;

ADOLESCENT; ADOLESCENT DISEASE; ARTICLE; CHILD; CHILDHOOD DISEASE; COMBINATION CHEMOTHERAPY; CORTICOSTEROID THERAPY; CROHN DISEASE; DRUG BLOOD LEVEL; DRUG MONITORING; DRUG WITHDRAWAL; FEMALE; HUMAN; JAPANESE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REMISSION; ULCERATIVE COLITIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALOPECIA; AMYLASE BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; ERYTHROCYTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFANT; INFLAMMATORY BOWEL DISEASE; JAPANESE (PEOPLE); LEUKOPENIA; MEDICAL RECORD REVIEW; SIDE EFFECT; TREATMENT DURATION;

EID: 77957560985     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2010.06364.x     Document Type: Article

References (22)

1. Jeshion WC, Larsen KL, Jawad AF et al. Azathioprine and 6-mercaptopurine for the treatment of perianal Crohn's disease in children. J. Clin. Gastroenterol. 2000 30 : 294 298.
2. Kader HA, Mascarenhas MR, Piccoli DA, Stouffer NO, Baldassano RN. Experiences with 6-mercaptopurine and azathioprine therapy in pediatric patients with severe ulcerative colitis. J. Pediatr. Gastroenterol. Nutr. 1999 28 : 54 8.
3. Markowitz J, Grancher K, Kohn N, Lesser M, Daum F, the Pediatric 6-MP Collaborative Group. A multicenter trial of 6-mercaptopurin and prednisone in children with newly diagnosed Crohn's disease. Gastroenterology. 2000 119 : 895 902.
4. Markowitz J, Grancher K, Kohn N, Daum F. Immunomodulatory therapy for pediatric inflammatory bowel disease: changing patterns of use, 1990-2000. Am. J. Gastroenterol. 2002 97 : 928 932.
5. Markowitz J, Grancher K, Mandel F, Daum F. Immunosuppressive therapy in pediatric inflammatory bowel disease: results of a survey of the North American Society for Pediatric Gastroenterology and Nutrition. Am. J. Gastroenterol. 1993 88 : 44 8.
6. Goldenberg BA, Rawsthorne P, Bernstein CN. The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease. Am. J. Gastroenterol. 2004 99 : 1744 1748.
7. Cuffari C, Hunt S, Bayless T. Utilisation of erythrocyte 6-thioguanine metabolite levels to optimize azathioprine therapy in patients with inflammatory bowel disease. Gut 2001 48 : 642 646.
8. Osterman MT, Kundu R, Lichtenstein GR, Lewis JD. Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology 2006 130 : 1047 1053.
9. Sandborn WJ. Rational dosing of azathioprine and 6-mercaptopurine. Gut 2001 48 : 591 592.
10. Ooi CY, Bohane TD, Lee D, Naidoo D, Day AS. Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. Aliment. Pharmacol. Ther. 2007 25 : 941 947.
11. Hibi T, Naganuma M, Kitahora T, Kinjyo F, Shimoyama T. Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis. J. Gastroenterol. 2003 38 : 740 746.
12. Hibi T, Inoue N, Ogata H, Naganuma M. Introduction and overview: recent advances in the immunotherapy of inflammatory bowel disease. J. Gastroenterol. 2003 38 (Suppl. 15 36 42.
13. Andoh A, Tsujikawa T, Ban H et al. Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease. J. Gastroenterol. Hepatol. 2008 23 : 1373 1377.
14. Turner D, Otley AR, Mack D et al. Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology 2007 133 : 423 432.
15. Hyams JS, Ferry GD, Mandel FS et al. Development and validation of a pediatric Crohn's disease activity index. J. Pediatr. Gastroenterol. Nutr. 1991 12 : 439 447.
16. Sandborn W, Sutherland L, Pearson D, May G, Modigliani R, Prantera C. Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease. Cochrane Database Syst. Rev. 2000 (2) : CD000545.
17. Pike MG, Franklin CL, Mays DC, Lipsky JJ, Lowry PW, Sandborn WJ. Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-metheylmercaptopurine nucleotides in blood. J. Chromatogr. B, Biomed. Sci. Appl. 2001 757 : 1 9.
18. Yates CR, Krynetski EY, Loennechen T et al. Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. Ann. Intern. Med. 1997 126 : 608 614.
19. Gupta P, Gokhale R, Kirschner BS. 6-mercaptopurine metabolite levels in children with inflammatory disease. J. Pediatr. Gastroenterol. Nutr. 2001 33 : 450 454.
20. Fuentes D, Torrente F, Keady S et al. High-dose azathioprine in children with inflammatory bowel disease. Aliment. Pharmacol. Ther. 2003 17 : 913 921.
21. Takatsu N, Matsui T, Murakami Y et al. Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease. J. Gastroenterol. Hepatol. 2009 24 : 1258 1264.
22. Uchiyama K, Nakamura M, Kubota T, Yamane T, Fujise K, Tajiri H. Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment. J. Gastroenterol. 2009 44 : 197 203.