Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution

Journal of Biomedical Optics

Volumn 15, Issue 4, 2010, Pages

  Fu, Ya Yuan ^a   Lu, Chih Hsuan ^a   Lin, Chi Wen ^a   Juang, Jyuhn Huarng ^b   Enikolopov, Grigori ^c   Sibley, Eric ^d   Chiang, Ann Shyn ^a   Tang, Shiue Cheng ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

3 D microscopy; Islets of Langerhans; microstructure; Vasculature

Indexed keywords

3-D MICROSCOPY; 3D VISUALIZATION; DYE-LABELING; HIGH RESOLUTION; IMAGE DATA; IN-SITU; ISLETS OF LANGERHANS; MICROSCOPIC IMAGING; MICROSCOPIC VISUALIZATION; OPTICAL CLEARING; OPTICAL METHODS; OPTICAL SECTIONS; PANCREATIC TISSUE; PATHOPHYSIOLOGY; PROJECTION ALGORITHMS; TISSUE ANALYSIS; TISSUE IMAGING; VASCULAR NETWORK; VASCULATURE;

BLOOD VESSELS; CONFOCAL MICROSCOPY; DATA VISUALIZATION; MAMMALS; MICROSCOPIC EXAMINATION; MICROSTRUCTURE; THREE DIMENSIONAL; TISSUE; VISUALIZATION;

THREE DIMENSIONAL COMPUTER GRAPHICS;

ALGORITHM; ANIMAL; ARTICLE; CELL FRACTIONATION; COMPUTER ASSISTED DIAGNOSIS; CONFOCAL MICROSCOPY; CYTOLOGY; EQUIPMENT; EQUIPMENT DESIGN; IMAGE ENHANCEMENT; METHODOLOGY; MICROVASCULATURE; MOUSE; PANCREAS ISLET; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SYSTEM ANALYSIS; THREE DIMENSIONAL IMAGING; ULTRASTRUCTURE; VASCULARIZATION;

ALGORITHMS; ANIMALS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; ISLETS OF LANGERHANS; MICE; MICROSCOPY, CONFOCAL; MICROVESSELS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUBCELLULAR FRACTIONS; SYSTEMS INTEGRATION;

EID: 77957367220     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3470241     Document Type: Article

References (36)

1. O. Cabrera, D. M. Berman, N. S. Kenyon, C. Ricordi, P. O. Berggrern, and A. Caicedo, "The unique cytoarchitecture of human pancreatic islets has implications for islet cell function," Proc. Natl. Acad. Sci. U.S.A. 103(7), 2334-2339 (2006). (Pubitemid 43271670)
2. J. Gromada, I. Franklin, and C. B. Wollheim, "Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains," Endocr. Rev. 28(1), 84-116 (2007). (Pubitemid 46220851)
3. F. C. Brunicardi, J. Stagner, S. Bonner-Weir, H. Wayland, R. Kleinman, E. Livingston, P. Guth, M. Menger, R. McCuskey, M. Intaglietta, A. Charles, S. Ashley, A. Cheung, E. Ipp, S. Gilman, T. Howard, and E. Passaro, "Microcirculation of the islets of Langerhans-Long Beach Veterans Administration Regional Medical Education Center Symposium," Diabetes 45(4), 385-392 (1996). (Pubitemid 26110241)
4. N. Ballian and F. C. Brunicardi, "Islet vasculature as a regulator of endocrine pancreas function," World J. Surg. 31(4), 705-714 (2007). (Pubitemid 46496227)
5. V. V. Tuchin, "A clear vision for laser diagnostics," IEEE J. Sel. Top. Quantum Electron. 13(6), 1621-1628 (2007).
6. R. K. K. Wang, X. Q. Xu, V. V. Tuchin, and J. B. Elder, "Concurrent enhancement of imaging depth and contrast for optical coherence tomography by hyperosmotic agents," J. Opt. Soc. Am. B 18(7), 948-953 (2001). (Pubitemid 33298615)
7. J. Y. Jiang, M. Boese, P. Turner, and R. K. K. Wang, "Penetration kinetics of dimethyl sulphoxide and glycerol in dynamic optical clearing of porcine skin tissue in vitro studied by Fourier transform infrared spectroscopic imaging," J. Biomed. Opt. 13(2), 021105 (2008).
8. E. A. Genina, A. N. Bashkatov, A. A. Korobko, E. A. Zubkova, V. V. Tuchin, I. Yaroslavsky, and G. B. Altshuler, "Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin," J. Biomed. Opt. 13(2), 021102 (2008).
9. M. G. Ghosn, E. F. Carbajal, N. A. Befrui, V. V. Tuchin, and K. V. Larin, "Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera," J. Biomed. Opt. 13(2), 021110 (2008).
10. A. T. Yeh and J. Hirshburg, "Molecular interactions of exogeneous chemical agents with collagen-implications for tissue optical clearing," J. Biomed. Opt. 11(1), 014003 (2006).
11. A. K. Bui, R. A. McClure, J. Chang, C. Stoianovici, J. Hirshburg, A. T. Yeh, and B. Choi, "Revisiting optical clearing with dimethyl sulfoxide (DMSO)," Lasers Surg. Med. 41(2), 142-148 (2009).
12. Y. C. Liu and A. S. Chiang, "High-resolution confocal imaging and three-dimensional rendering," Methods 30(1), 86-93 (2003).
13. H. H. Lin, J. S. Lai, A. L. Chin, Y. C. Chen, and A. S. Chiang, "A map of olfactory representation in the Drosophila mushroom body," Cell 128(6), 1205-1217 (2007). (Pubitemid 46427885)
14. Y. Wang, A. Mamiya, A. S. Chiang, and Y. Zhong, "Imaging of an early memory trace in the Drosophila mushroom body," J. Neurosci. 28(17), 4368-4376 (2008).
15. Y. Y. Fu, C. W. Lin, G. Enikolopov, E. Sibley, A. S. Chiang, and S. C. Tang, "Microtome-free 3-dimensional confocal imaging method for visualization of mouse intestine with subcellular-level resolution," Gastroenterology 137(2), 453-465 (2009).
16. S. J. Tseng, Y. H. Lee, Z. H. Chen, H. H. Lin, C. Y. Lin, and S. C. Tang, "Integration of optical clearing and optical sectioning microscopy for three-dimensional imaging of natural biomaterial scaffolds in thin sections," J. Biomed. Opt. 14(4), 044004 (2009).
17. Carl Zeiss Microimaging GmbH, "Visualizing the architecture of cells and tissues," Brochures for Laser Scanning Microscopy, available at http://www.zeiss.de/micro (2009).
18. D. J. Ravnic, X. Jiang, T. Wolloscheck, J. P. Pratt, H. Huss, S. J. Mentzer, and M. A. Konerding, "Vessel painting of the microcirculation using fluorescent lipophilic tracers," Microvasc. Res. 70(1-2), 90-96 (2005). (Pubitemid 41565413)
19. Y. Li, Y. Song, L. Zhao, G. Gaidosh, A. M. Laties, and R. Wen, "Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI," Nat. Protoc. 3(11), 1703-1708 (2008).
20. M. Hara, R. F. Dizon, B. S. Glick, C. S. Lee, K. H. Kaestner, D. W. Piston, and V. P. Bindokas, "Imaging pancreatic beta-cells in the intact pancreas," Am. J. Physiol.-Endocrinol. Metab. 290(5), E1041-E1047 (2006).
21. T. Alanentalo, C. E. Loren, A. Larefalk, J. Sharpe, D. Holmberg, and U. Ahlgren, "High-resolution three-dimensional imaging of isletinfiltrate interactions based on optical projection tomography assessments of the intact adult mouse pancreas," J. Biomed. Opt. 13(5), 054070 (2008).
22. J. L. Mignone, V. Kukekov, A. S. Chiang, D. Steindler, and G. Enikolopov, "Neural stem and progenitor cells in nestin-GFP transgenic mice," J. Comp. Neurol. 469(3), 311-324 (2004). (Pubitemid 38140640)
23. A. Delacour, V. Nepote, A. Trumpp, and P. L. Herrera, "Nestin expression in pancreatic exocrine cell lineages," Mech. Dev. 121(1), 3-14 (2004). (Pubitemid 38050174)
24. A. S. Chiang, "Aqueous tissue clearing solution," U.S. Patent No. 6,472,216 (2002).
25. N. S. Goldstein, A. Soman, and J. Sacksner, "Disparate surgical margin lengths of colorectal resection specimens between in vivo and in vitro measurements. The effects of surgical resection and formalin fixation on organ shrinkage," Am. J. Clin. Pathol. 111(3), 349-351 (1999). (Pubitemid 29102743)
26. D. Holmberg and U. Ahlgren, "Imaging the pancreas: from ex vivo to non-invasive technology," Diabetologia 51(12), 2148-2154 (2008).
27. J. Virostko and A. C. Powers, "Molecular imaging of the pancreas in small animal models," Gastroenterology 136(2), 407-409 (2009).
28. L. R. Nyman, K. S. Wells, W. S. Head, M. McCaughey, E. Ford, M. Brissova, D. W. Piston, and A. C. Powers, "Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets," J. Clin. Invest. 118(11), 3790-3797 (2008).
29. S. Speier, D. Nyqvist, O. Cabrera, J. Yu, R. D. Molano, A. Pileggi, T. Moede, M. Kohler, J. Wilbertz, B. Leibiger, C. Ricordi, I. B. Leibiger, A. Caicedo, and P. O. Berggren, "Noninvasive in vivo imaging of pancreatic islet cell biology," Nat. Med. 14(5), 574-578 (2008). (Pubitemid 351655207)
30. M. C. Denis, U. Mahmood, C. Benoist, D. Mathis, and R. Weissleder, "Imaging inflammation of the pancreatic islets in type 1 diabetes," Proc. Natl. Acad. Sci. U.S.A. 101(34), 12634-12639 (2004). (Pubitemid 39122075)
31. S. E. Turvey, E. Swart, M. C. Denis, U. Mahmood, C. Benoist, R. Weissleder, and D. Mathis, "Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes," J. Clin. Invest. 115(9), 2454-2461 (2005). (Pubitemid 41266207)
32. Z. Medarova, G. Castillo, G. Dai, E. Bolotin, A. Bogdanov, and A. Moore, "Noninvasive magnetic resonance imaging of microvascular changes in type 1 diabetes," Diabetes 56(11), 2677-2682 (2007). (Pubitemid 350044908)
33. F. Souza, M. Freeby, K. Hultman, N. Simpson, A. Herron, P. Witkowsky, E. Liu, A. Maffei, and P. E. Harris, "Current progress in non-invasive imaging of beta cell mass of the endocrine pancreas," Curr. Med. Chem. 13(23), 2761-2773 (2006). (Pubitemid 44509723)
34. M. M. Martinic and M. G. von Herrath, "Real-time imaging of the pancreas during development of diabetes," Immunol. Rev. 221, 200-213 (2008). (Pubitemid 351230108)
35. M. Villiger, J. Goulley, M. Friedrich, A. Grapin-Botton, P. Meda, T. Lasser, and R. A. Leitgeb, "In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy," Diabetologia 52(8), 1599-1607 (2009).
36. W. J. Malaisse, K. Louchami, and A. Sener, "Noninvasive imaging of pancreatic beta cells," Nat. Rev. Endocrinol. 5(7), 394-400 (2009).