Ocular hemorrhages in neonatal porcine eyes from single, rapid rotational events

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 9, 2010, Pages 4792-4797

  Coats, Brittany ^a   Binenbaum, Gil ^b,c   Peiffer, Robert L ^c,d   Forbes, Brian J ^b,c   Margulies, Susan S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ARTICLE; AXONAL INJURY; BRAIN HEMORRHAGE; CILIARY BODY; CONTROLLED STUDY; EYE EXAMINATION; HEAD INJURY; HEAD MOVEMENT; HISTOPATHOLOGY; INCIDENCE; INTRAOCULAR HEMORRHAGE; NERVE SHEATH; NEWBORN; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; RETINA HEMORRHAGE; RETROSPECTIVE STUDY; SWINE; VITREOUS BODY; ANIMAL; BRAIN; BRAIN INJURY; DISEASE MODEL; HEAD; INJURY; OPTIC NERVE INJURY; PATHOLOGY; RETINA; ROTATION; SPECIES DIFFERENCE;

ANIMALS; ANIMALS, NEWBORN; ANTERIOR CHAMBER; BRAIN; BRAIN INJURIES; DISEASE MODELS, ANIMAL; HEAD; OPTIC NERVE INJURIES; RETINA; RETINAL HEMORRHAGE; ROTATION; SPECIES SPECIFICITY; SWINE; VITREOUS BODY;

EID: 77957364801     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5211     Document Type: Article

References (35)

1. Frasier LD. Abusive head trauma in infants and young children: a unique contributor to developmental disabilities. Pediatr Clin N Am. 2008;55:1269-1285.
2. Overpeck MD, Brenner RA, Trumble AC, Trifiletti LB, Berendes HW. Risk factors for infant homicide in the United States. N Engl J Med. 1998;339:1211-1216.
3. Jenny C, Hymal K, Ritzen A, Reinert S, Hay T. Analysis of missed cases of abusive head trauma. JAMA. 1999;281:621-626.
4. Armstead W, Kurth C. Different cerebral hemodynamic responses following fluid percussion brain injury in the newborn and juvenile pig. J Neurotrauma. 1994;11:487-497.
5. Finnie J, Blumbergs P, Manavis J. Multi-focal cerebellar granular layer necrosis in traumatically head-injured lambs. Vet Pathol. 1999;36:256-258.
6. Margulies SS, Meaney DF Smith D, Chen X-H, Miller R, Raghupathi R. A Comparison of Diffuse Brain Injury in the Newborn and Adult Pig. Barcelona, Spain: International Research Committee on the Biomechanics of Impact. 1999.
7. Prange M, Margulies S. Anisotropy and Inhomogeneity of the Mechanical Properties of Brain Tissue at Large Deformation. Presented at Prevention Through Biomechanics. Novi, MI; 1999.
8. Prange M, Margulies S. Tissue Strain Thresholds for Axonal Injury in the Infant Brain. In: Kamm R, ed. Bioengineering Conference, Snowbird, UT. New York: The American Society of Mechanical Engineers; 2001:833-834.
9. Raghupathi R, Margulies SS. Traumatic axonal injury after closed head injury in the neonatal pig. J Neurotrauma. 2002;19:843-853.
10. Shaver E, Duhaime AC, Curtis M, Gennarelli L, Barrett R. Experimental acute subdural hematoma in infant piglets. Pediatr Neurosurg. 1996;25:123-129.
11. Duhaime AC, Margulies SS, Durham SR, et al. Maturation-dependent response of the piglet brain to scaled cortical impact. J Neurosurg. 2000;93:455-462.
12. Christian C, Taylor A, Hertle R, Duhaime A. Retinal hemorrhages caused by accidental household trauma. J Pediatrics. 1999;135:125-127.
13. Johnson D, Braun D, Friendly D. Accidental head trauma and retinal hemorrhage. Neurosurgery. 1993;33:231-235.
14. Sturm V, Knecht PB, Landau K, Menke MN. Rare retinal haemorrhages in translational accidental head trauma in children. Eye (Lond). 2009;23(7):1535-1541.
15. Trenchs V, Curcoy A, Morales M, Serra A, Navarro R, Pou J. Retinal hemorrhages in head trauma resulting from falls: differential diagnosis with non-accidental trauma in patients younger than 2 years of age. Child Nervous Syst. 2008;24:815-820.
16. Duhaime A, Alario A, Lewander W, et al. Head injury in very young children: mechanisms, injury types, and ophthalmologic findings in 100 hospitalized patients under two years of age. Pediatrics.1992;90:179-185.
17. Kivlin J, Currie M, Greenbaum V, Simons K, Jentzen J. Retinal hemorrhages in children following fatal motor vehicle crashes: a case series. Arch Ophthalmology. 2008;126:800-804.
18. Budenz D, Farber M, Mirchandani H, Park H, Rorke L. Ocular andoptic nerve hemorrhages in abused infants with intracranial injuries. Ophthalmology. 1994;101:559-565.
19. Elner SG, Elner VM, Arnall M, Albert DM. Ocular and associated systematic findings in suspected child abuse: a necropsy study. Arch Ophthalmol. 1990;108:1094-1101.
20. Emerson MV, Jakobs E, Green WR. Ocular autopsy and histopathologic features of child abuse. Ophthalmology. 2007;1384-1394.
21. Marshall DH, Brownstein S, Dorey MW, Addison DJ, Carpenter B. The spectrum of postmortem ocular findings in victims of shaken baby syndrome. Can J Ophthalmol. 2001;36:377-383.
22. Riffenburgh R, Sathyavagiswaran L. Ocular findings at autopsy of child abuse victims. Ophthalmology. 1991;98:1519-1524.
23. Wygnanski-Jaffe T, Levin A, Shafiq A, et al. Postmortem orbital findings in shaken baby syndrome. Am J Ophthalmol. 2006;142:233-240.
24. Gandorfer A, Putz E, Welge-Lussen U, Gruterich M, Ulbig M, Kampik A. Ultrastructure of the vitreoretinal interface following plasmin assisted vitrectomy. Br J Ophthalmol. 2001;85:6-10.
25. Prince J, Diesem C, Eglitis I, Ruskell G. Anatomy and Histology of the Eye and Orbit in Domestic Animals. Springfield: Charles C. Thomas; 1960:307.
26. Rootman J. Vascular system of the optic nerve head and retina in the pig. Br J Ophthalmol. 1971;808-819.
27. De Schaepdrijver L, Simoens P, Lauwers H, De Geest J, Charlier G. The hyaloid vascular system of the pig. Anat Embryol. 1989;180:549-554.
28. Sebag J. Anatomy and pathology of the vitreoretinal interface. Eye. 1992;6:541-552.
29. Sebag J, Balazs EA. Morphology and ultrastructure of human vitreous fibers. Invest Ophthalmol Vis Sci. 1989;30:1867-1871.
30. Bonnier C, Mesples B, Carpentier S, Henin D, Gressens P. Delayed white matter injury in a murine model of shaken baby syndrome. Brain Pathol. 2002;12:320-328.
31. Prange M, Coats B, Duhaime AC, Margulies S. Anthropomorphic simulations of falls, shakes, and inflicted impacts in infants. J Neurosurg. 2003;99:143-150.
32. Coats B, Margulies SS. Potential for head injuries in infants from low-height falls. J Neurosurg Pediatr. 2008;2:1-10.
33. Duhaime A, Gennarelli T, Thibault L, Bruce D, Margulies S, Wiser R. The shaken baby syndrome: a clinical, pathological, and biomechanical study. J Neurosurg. 1987;66:409-415.
34. Bron A, ed. Wolf's Anatomy of the Eye and Orbit. 8th ed. New York: Chapman & Hall Medical; 1997:736.
35. Fledelius H. Pre-term delivery and the growth of the eye. an oculometric study of eye size around term-time. Acta Ophthalmol. 1992;204(suppl):10-15.