Morphologic changes and methodological issues in the rabbit experimental model for diaphragmatic hernia

Histology and Histopathology

Volumn 25, Issue 9, 2010, Pages 1105-1116

  Roubliova, Xenia I ^a   Deprest, Jan A ^a,b   Biard, Jean Marc ^a   Ophalvens, Lieve ^b   Gallot, Denis ^a   Jani, Jacques C ^a   Ven De Van, Cornelis P ^c   Tibboel, Dick ^c   Verbeken, Erik K ^b  

^a Center for Surgical Technologies Leuven   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Lung; Morphometry; Prenatal

Indexed keywords

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ANIMAL; ARTICLE; CONGENITAL MALFORMATION; DIAPHRAGM HERNIA; DISEASE MODEL; LUNG; METHODOLOGY; PATHOLOGY; RABBIT; RESPIRATORY TRACT MALFORMATION; TISSUE FIXATION;

ANIMALS; DISEASE MODELS, ANIMAL; HERNIA, DIAPHRAGMATIC; LUNG; RABBITS; RESPIRATORY SYSTEM ABNORMALITIES; TISSUE FIXATION;

EID: 77957355435     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Ackerman K. G., Herron B. J., Vargas S. O., Huang H., Tevosian S. G., Kochilas L., Rao C., Pober B. R., Babiuk R. P., Epstein J. A., Greer J. J. and Beier D. R. (2005). Fog2 is required for normal diaphragm and lung development in mice and humans. Plo. S. Genet. 1, 58-65.
2. Areechon W. and Reid L. (1963). Hypoplasia of lung with congenital diaphragmatic hernia. Br. Med. J. 1, 230-233.
3. Askenazi S. S. and Perlman M. (1979). Pulmonary hypoplasia: lung weight and radial alveolar count as criteria of diagnosis. Arch. Dis. Child. 54, 614-618.
4. Bargy F., Beaudoin S. and Barbet P. (2006). Fetal lung growth in congenital diaphragmatic hernia. Fet. Diagn. Ther. 21, 39-44.
5. Chinoy M. R. (2002). Pulmonary hypoplasi. and congenital diaphragmatic hernia: advances in the pathogenetics and regulation of lung development. J. Surg. Res. 106, 209-223.
6. Chinoy M. R. (2003). Lung growth and development. Front. Biosc. 8, d392-415.
7. Clugston R. D., Klattig J., Englert C., Clagett-Dame M., Martinovic J., Benachi A. and Greer J. J. (2006). Teratogen-induced, dietary and genetic models of congenital diaphragmatic hernia share a common mechanism of pathogenesis. Am. J. Pathol. 169, 1541-1549.
8. Cumming G., Horsfield K., Harding L. K. and Prowse K. (1971). Biological branching systems, with special reference to the lung airways. Bull. Physiopathol. Respir. (Nancy) 7, 31-40.
9. Davey M. G., Danzer E., Schwarz U., Robinson L., Shegu S., Adzick N. S., Flake A. W. and Hedrick H. L. (2006). Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion. Pediatr. Pulmonol. 41, 1188-96.
10. De Paepe M. E., Johnson B. D., Papadakis K. and Luks F. I. (1999). Lung growth response after tracheal occlusion in fetal rabbits is gestational age-dependent. Am. J. Respir. Cell. Mol. Biol. 21, 65-76.
11. DiFiore J. W. and Wilson J. M. (1995). Lung Liquid, fetal lung growth and congenital diaphragmatic hernia. Pediatr. Surg. Intl. 10, 2-9.
12. DiFiore J. W., Fauza D. O., Slavin R., Peters C. A., Fackler J. C. and Wilson J. M. (1994). Experimental fetal tracheal ligation reverses the structural and physiological effects of pulmonary hypoplasia in congenital diaphragmatic hernia. J. Pediatr. Surg. 29, 248-256.
13. Doolin E. J., Strande L. and Attori R. J. (1995). Morphometry and histochemistry of pulmonary arteries in a hypoplastic lung model. J. Surg. Res. 59, 191-197.
14. Dolnikoff M., Dallaire M. and Ludwig M. S. (1995). Lung tissue distortion in response to methacholine in rats: effect on lung volume. J. Appl. Physiol. 79, 533-538.
15. Fauza D. O., Tannuri U., Ayoub A. A., Capelozzi V. L., Saldiva P. H. and Maksoud J. G. (1994). Surgically produced congenital diaphragmatic hernia in fetal rabbits. J. Pediatr. Surg. 29, 882-86.
16. Flemmer A. W., Jani J. C., Bergmann F., Muensterer O. J., Gallot D., Hajek K., Sugawara J., Till H. and Deprest J. A. (2007). Lung tissue mechanics predict lung hypoplasia in a rabbit model for congenital diaphragmatic hernia. Pediatr. Pulmonol. 42, 505-12.
17. Geggel R. L., Murphy J. D., Langleben D., Crone R. K., Vacanti J. P. and Reid L. M. (1985). Congenital diaphragmatic hernia: arterial structural changes and persistent pulmonary hypertension after surgical repair. J. Pediatr. 107, 457-464.
18. Guarino N., Teramoto H., Shima H., Oue T. and Puri P. (2002). Effect of mechanical ventilation on the pulmonary expression and production of elastin in nitrofen-induced diaphragmatic hernia in rats. J. Pediatr. Surg. 37, 1253-1257.
19. Gundersen H. J., Bendtsen T. F., Korbo L., Marcussen N., Møller A., Nielsen K., Nyengaard J. R., Pakkenberg B., Sørensen F. B. and Vesterby A. (1988). Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96, 379-394.
20. Hooper S. B. and Harding R. (2001). Respiratory system. In: Fetal growth and development. Harding R. and Bocking A. D. (eds). Cambridge University Press. Cambrige. p 114.
21. Kay J. M. (1983). Pulmonary vasculature and nerves. Comparative morphologic features of the pulmonary vasculature in mammals. Am. Rev. Respir. Dis. 128, S53-S57.
22. Kitagawa M., Hislop A., Boyden E. A. and Reid L. (1971). Lung hypoplasia in congenital diaphragmatic hernia. A quantitative study of airway, artery, and alveolar development. Br. J. Surg. 58, 342-46.
23. Kitano Y., Davies P., von Allmen D., Adzick N. S. and Flake A. W. (1999). Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia. J. Appl. Physiol. 87, 769-775.
24. Kluth D., Kangah R., Reich P., Tenbrinck R., Tibboel D. and Lambrecht W. (1990). Nitrofen-induced diaphragmatic hernias in rats: an animal model. J. Pediatr. Surg. 25, 850-854.
25. Kuhn C. 3rd, Homer R. J., Zhu Z., Ward N., Flavell R. A., Geba G. P. and Elias J. A. (2000). Airway hyper responsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung. Am. J. Respir. Cell. Mol. Biol. 22, 289-295.
26. Lipsett J., Cool J. C., Runciman S. C., Kennedy J. D., Martin A. J., Byard R. W. and Ford W. D. (1997). Morphometric analysis of pulmonary development in the sheep following creation of fetal diaphragmatic hernia. Pediatr. Pathol. Lab. Med. 17, 789-807.
27. Lotze A., Knight G. R., Anderson K. D., Hull W. M., Whitsett J. A., O'Donnell R. M., Martin G., Bulas D. I. and Short B. L. (1994). Surfactant (beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: evidence of persistent surfactant deficiency. J. Pediatr. Surg. 29, 407-412.
28. Luks F. I., Wild Y. K., Piasecki G. J. and De Paepe M. E. (2000). Shortterm tracheal occlusion corrects pulmonary vascular anomalies in the fetal lamb with diaphragmatic hernia. Surgery 128, 266-72.
29. Ohi R., Suzuki H., Kato T. and Kasai M. (1976). Development of the lung in fetal rabbits with experimental diaphragmatic hernia. J. Pediatr. Surg. 11, 955-59.
30. Pache J. C., Roberts N., Vock P., Zimmermann A. and Cruz-Orive L. M. (1993). Vertical LM sectioning and parallel CT scanning designs for stereology: application to human lung. J. Microsc. 170, 9-24.
31. Pringle K. C. (1986). Human fetal lung development and related animal models. Clin. Obstet. Gynecol. 29, 502-513.
32. Rajatapiti P., Keijzer R., Blommaart P. E., Lamers W. H., De Krijger R., Visser T. J., Tibboel D. and Rottier R. (2006). Spatial and temporal expression of glucocorticoid, retinoid, and thyroid hormone receptors is not altered in lungs of congenital diaphragmatic hernia. Pediatr. Res. 60, 693-698.
33. Rodrigues C. J., Tannuri U., Tannuri A. C., Maksoud-Filho J. and Rodrigues A. J. Jr (2002). Prenatal tracheal ligation or intra-amniotic administration of surfactant or dexamethasone prevents some structural changes in the pulmonary arteries of surgically created diaphragmatic hernia in rabbits. Rev. Hosp. Clin. Fac. Med. Sao Paulo 57, 1-8.
34. Roubliova X., Verbeken E., Wu J., Yamamoto H., Lerut T., Tibboel D. and Deprest J. (2004). Pulmonary vascular morphology in a fetal rabbit model for congenital diaphragmatic hernia. J. Pediatr. Surg. 39, 1066-1772.
35. Roubliova X. I., Lewi P. J., Vaast P., Jani J. C., Verbeken E. K., Tibboel D. and Deprest J. A. (2008). Effects of betamethasone on peripheral arterial development in term fetal rabbit. Pediatr. Pulmonol. 43, 795-805.
36. Roubliova X. I., Lewi P. J., Verbeken E. K., Vaast P., Jani J. C., Lu H., Tibboel D. and Deprest J. A. (2009). The effect of maternal betamethasone and fetal tracheal occlusion on pulmonary vascular morphometry in fetal rabbits with surgically induced diaphragmatic hernia: a placebo controlled morphologic study. Prenat. Diagn. 29, 674-681.
37. Shehata S. M., Tibboel D., Sharma H. S. and Mooi W. J. (1999). Impaired structural remodelling of pulmonary arteries in newborns with congenital diaphragmatic hernia: a histological study of 29 cases. J. Pathol. 189, 112-18.
38. Shehata S. M., Sharma H. S., van der Staak F. H., van de Kaa-Hulsbergen C., Mooi W. J. and Tibboel D. (2000). Remodeling of pulmonary arteries in human congenital diaphragmatic hernia with or without extracorporeal membrane oxygenation. J. Pediatr. Surg. 35, 208-215.
39. Singhal S., Henderson R., Horsfield K., Harding K. and Cumming G. (1973). Morphometry of the human pulmonary arterial tree. Circ. Res. 33, 190-197.
40. Skari H., Bjornland K., Haugen G., Egeland T. and Emblem R. (2000). Congenital diaphragmatic hernia: a metaanalysis of mortality factors. J. Pediatr. Surg. 35, 1187-1197.
41. Stolar C. J. and Dillon P. W. (1990). Extracorporeal membrane oxygenation and congenital diaphragmatic hernia. Surgery 108, 121-122.
42. Tannuri U., Maksoud-Filho J. G., Santos M. M., Tannuri A. C. A., Rodrigues C. J. and Rodrigues A. J., Jr (1998). The effects of prenatal intraamniotic surfactant or dexamethasone administration on lung development are comparable to changes induced by tracheal ligation in an animal model of congenital diaphragmatic hernia. J. Pediatr. Surg. 33, 1198-1205.
43. Verbeken E. K., Cauberghs M., Mertens I., Clement J., Lauweryns J. M. and Van de Woestijne K. P. (1992). The senile lung: comparison with normal and emphysematous lung: 1. Structural aspects. Chest 101, 793-799.
44. Verbeken E. K., Cauberghs M., Lauweryns J. M. and Van de Woestijne K. P. (1994). Structure and function in fibrosing alveolitis. J. Appl. Physiol. 76, 731-742.
45. Verbeken E. K., Cauberghs M. and van de Woestijne K. P. (1996). Membranous bronchioles and connective tissue network of normal and emphysematous lung. J. Appl. Physiol. 81, 2468-80.
46. Weibel E. R., Hsia C. C. W. and Ochs M. (2007). How much is there really? Why stereology is essential in lung morphometry. J. Appl. Physiol. 102, 459-467.
47. Wu J., Yamamoto H., Gratacos E., Ge X., Verbeken E., Sueishi K., Hashimoto S., Vanamo K., Lerut T. and Deprest J. (2000). Lung development following diaphragmatic hernia in the fetal rabbit. Hum. Reprod. 15, 2483-88.
48. Yamataka T. and Puri P. (1997). Pulmonary artery structural changes in pulmonary hypertension complicating congenital diaphragmatic hernia. J. Pediatr. Surg. 32, 387-390. (Pubitemid 27147654)
49. You L. R., Takamoto N., Yu C. T., Tanaka T., Kodama T., Demayo F. J., Tsai S. Y. and Tsai M. J. (2005). Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia. Proc. Natl. Acad. Sci. USA 102, 16351-16356.