Effect of artificial mucus properties on the characteristics of airborne bioaerosol droplets generated during simulated coughing

Journal of Non-Newtonian Fluid Mechanics

Volumn 165, Issue 21-22, 2010, Pages 1431-1441

  Anwarul Hasan, M D ^a   Lange, Carlos F ^a   King, Malcolm L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Bioaerosol droplets; Cough machine; Lung mucus; Surface tension; Viscoelasticity

Indexed keywords

AXISYMMETRIC DROP SHAPE ANALYSIS; BIOAEROSOLS; COUGH MACHINE; ELASTIC SOLIDS; HUMAN AIRWAY; IN-VITRO; LASER DIFFRACTIONS; LOCUST BEAN GUM; LUNG MUCUS; PELTIER; PLATE ASSEMBLIES; SODIUM DODECYL SULFATE; SODIUM TETRABORATE; VISCOELASTIC PROPERTIES; VISCOUS FLUIDS; VOLUME CONCENTRATION;

AEROSOLS; BIOLOGICAL ORGANS; DROP FORMATION; ELASTICITY; PARTICLE SIZE; SIZE DISTRIBUTION; SODIUM; SODIUM SULFATE; SURFACE ACTIVE AGENTS; SURFACE PROPERTIES; SURFACE TENSION; VISCOELASTICITY; VISCOSITY;

BODY FLUIDS;

EID: 77957349166     PISSN: 03770257     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnnfm.2010.07.005     Document Type: Article

References (43)

1. Vasudevan M., Lange C.F. Surface tension effects on instability in viscoelastic respiratory fluids. Math. Biosci. 2007, 205:180-194.
2. M. King, J.G. Zayas, Compositions and methods for improved respiratory tract mucus clearance, U.S. Provisional Patent 10/599,578, March 2004.
3. Des Prez R., Heim C. Mycobacterium tuberculosis. Principles and Practices of Infectious Diseases 1990, 1877-1906. Churchill Livingstone, New York. G. Mandell, J.R. Douglas, J. Bennett (Eds.).
4. J. Lavoie, Y. Cloutier, J. Lara, G. Marchand, Guide on respiratory protection against bioaerosols-recommendations on its selection and use, Studies and Research Projects/Technical Guide RG-501, IRSST, IRSST Publications Montréal, 2007.
5. Cox C.S. The Aerobiological Pathway of Microorganisms 1987, John Wiley and Sons Ltd., Chichester.
6. ACGIH, American Conference of Governmental Industrial Hygienists (ACGIH) Bioaerosols: Assessment and Control 1999, ACGIH, Cincinnati, OH.
7. Lenhart S.W., Seitz T., Trout D., Bollinger N. Issues affecting respirator selection for workers exposed to infectious aerosols: emphasis on healthcare settings. Appl. Biosaf. 2004, 9:2-36.
8. Cole E.C., Cook C.E. Characterization of infectious aerosols in health care facilities: an aid to effective engineering controls and preventive strategies. Am. J. Infect. Control 1998, 26:453-464.
9. Biosafety Reference Manual 2000, American Industrial Hygiene Association Publications (AIHA), Fairfax, VA. second edition.
10. N. Goyer, J. Lavoie, L. Lazure, G. Marchand, Les bioaérosols en milieu de travail: Guide d'évaluation, de contrôle et de prévention. Études et recherches, guide technique T-23, Institut de recherche Robert-Sauvé en santé et en sécurité du travail, 2001.
11. Lee S.A., Adhikari A., Grinshpun S.A., Mckay R., Shukla R., Zeigler H.L., Reponen T. Respiratory protection provided by N95 filtering face piece respirators against airborne dust and microorganisms in agricultural farms. J. Occup. Environ. Hyg. 2005, 2:577-583.
12. Yassi A., Bryce E. Protecting the Faces of Health Care Workers: Knowledge Gaps and Research Priorities for Effective Protection Against Occupationally-acquired Respiratory Infectious Diseases 2004, The Change Foundation, Ontario Hospital Association and Occupational Health and Safety Agency for Healthcare in BC.
13. Stahlhofen W., Gebhart J., Heyder J., Philipson K., Camner P. Intercomparison of experimental regional aerosol deposition data. J. Aerosol Med. 1989, 2:285-308.
14. Gerrity T.R. Calculated deposition of inhaled particles in the airway generations of normal subjects. J. Appl. Physiol. 1979, 47:867-873.
15. Hinds W.C. Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles 1982, John Wiley and Sons, Toronto.
16. Duguid J.P. The numbers and sites of origin of the droplets expelled during expiratory activities. Edinburgh Med. J. 1945, 52:385-401.
17. Duguid J.P. The size and the duration of air-carriage of respiratory droplets and droplet-nuclei. J. Hyg. 1946, 4:471-480.
18. Loudon R.G., Roberts R.M. Droplet expulsion from the respiratory tract. Am. Rev. Res. Dis. 1967, 95:433-442.
19. Papineni R.S., Rosenthal F.S. The size distribution of droplets in the exhaled breath of healthy human subjects. J. Aerosol Med. 1997, 10:105-116.
20. Edwards D.A., Man J.C., Brand P., Katstra J.P., Sommerer K., Stone H.A., Nardell E., Scheuch G. Inhaling to mitigate exhaled bioaerosols. Proc. Natl. Acad. Sci. U.S.A. 2004, 17383-17388.
21. Fairfield C.I., Stampfer J.F. Particle concentration in exhaled breath. Am. Ind. Hyg. Assoc. J. 1987, 48:948-949.
22. Clarke R., Katstra J., Man J., Dehaan W., Edwards D.A., Griel L.C. Pulmonary delivery of anti-contagion aerosol to diminish exhaled bioaerosols and airborne infectious disease. Am. J. Infect. Control 2005, 33:e85.
23. Watanabe W., Thomas M., Clarke R., Klibanov A.M., Langer R., Katstra J., Fuller G.G., Griel L.C., Fiegel J., Edwards D. Why inhaling salt water changes what we exhale. J. Colloid Interface Sci. 2007, 307:71-78.
24. Evrensel C.A., Khan Md.R.U., Krumpe P.E. Response of a viscoelastic layer (mucus) to turbulent airflow in a rigid tube. Technol. Health Care 2008, 16:355-366.
25. Clarke S.W., Jones J.G., Oliver D.R. Resistance to two-phase gas-liquid flow in airways. J. Appl. Physiol. 1970, 29:464-471.
26. King M., Brock G., Lundell C.C. Clearance of mucus by simulated cough. J. Appl. Physiol. 1985, 58:1776-1982.
27. Evrensel C.A., Hassan A.A., Krumpe P.E. An experimental investigation of interaction of airflow with a viscoelastic layer. Advances in Bioengineering 1998, vol. 39:93-94. ASME BED.
28. King M., Chang H.K., Weber M.E. Resistance of mucus-lined tubes to steady and oscillatory airflow. J. Appl. Physiol. 1982, 52:1172-1776.
29. Hassan A.A., Evrensel C.A., Krumpe P.E. Clearance of viscoelastic mucus simulant with airflow in a rectangular channel, an experimental study. Technol. Health Care 2006, 14:1-11.
30. Gad-El-Hak M. The response of elastic and viscoelastic surfaces to a turbulent boundary layer. J. Fluid Mech. 1986, 53:206-212.
31. Gad-El-Hak M., Blackwelder R.F., Riley J.J., James J. On the interaction of a compliant coatings with boundary layer flows. J. Fluid Mech. 1984, 140:257-280.
32. Evrensel C.A., Hassan A.A., Korver K.F., Krumpe P.E. High-speed visualization of the airflow-viscoelastic-layer interface. Proceedings of the Third Biannual Conference on Engineering Systems Design and Analysis, vol. 77 1996, 183-188. A.E. Engin (Ed.).
33. Evrensel C.A., Kalnins A. Response of a viscoelastic slab to a viscous fluid flow. J. Appl. Mech. 1988, 55:660-666.
34. Evrensel C.A., Kalnins A. Response of a compliant slab to inviscid incompressible fluid flow. J. Acoust. Soc. Am. 1985, 78:2034-2041.
35. Evrensel C.A., Khan Md.R.U., Elli S., Krumpe P.E. Viscous airflow through a rigid tube with compliant lining: a simple model for the air-mucus interaction in pulmonary airways. Trans. ASME J. Biomech. Eng. 1993, 115:262-269.
36. Evrensel C.A., Khan Md.R.U. Interaction of laminar airflow with viscoelastic airway mucus. Technol. Health Care 2003, 11:149-159.
37. Zhang Y., Finlay W.H., Matida E.A. Particle deposition measurements and numerical simulation in a highly idealized mouth-throat. J. Aerosol Sci. 2004, 35:789-803.
38. Shah S., Fung K., Brim S., Rubin B.K. An in vitro evaluation of the effectiveness of endotracheal suction catheters. Chest 2005, 128:3699-3704.
39. Lasheras J.C., Villermaux E., Hopfinger E.J. Break-up and atomization of a round water jet by a high speed annular air jet. J. Fluid Mech. 1998, 357:351-379.
40. Lasheras J.C., Hopfinger E.J. Liquid jet instability and atomization in a coaxial gas stream. Annu. Rev. Fluid Mech. 2000, 32:275-308.
41. Vasudevan M., Lange C.F. Property dependence of onset of instability in viscoelastic respiratory fluids. Int. J. Eng. Sci. 2005, 43:1292-1298.
42. Rubin B.K., Ramirez O., Zayas J.G., Finegan B., King M. Collection and analysis of respiratory mucus from subjects without lung disease. Am. Rev. Respir. Dis. 1990, 141:1040-1043.
43. Zayas G., Valle J.C., Allonso M., Alfaro H., Vega D., Bonilla G., Reyes M., King M. A new paradigm in respiratory hygiene: modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance. BMC Pulm. Med. 2007, 7. 10.1186/1471-2466-7-11.