The toxicology of inhaled particles: Summing up an emerging conceptual framework

Particle Toxicology

Volumn , Issue , 2006, Pages 413-424

  Donaldson, Ken ^a   Tran, Lang ^b   Borm, Paul J A ^c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b INSTITUTE OF OCCUPATIONAL MEDICINE   (United Kingdom)

^c ZUYD UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77957339364     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (49)

1. Balashazy, I., Hofmann, W., and Heistracher, T., Local particle deposition patterns may play a key role in the development of lung cancer, J. Appl. Physiol., 94, 1719-1725, 2003.
2. Barrett, E. G., Johnston, C., Oberdörster, G., and Finkelstein, J. N., Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure, Toxicol. Appl. Pharmacol., 158, 211-220, 1999.
3. Calderon-Garciduenas, L., Reed, W., Maronpot, R. R., Henriquez-Roldan, C., gado-Chavez, R., Calderon-Garciduenas, A., and Dragustinovis, I. et al., Brain inflammation and Alzheimer’s-like pathology in individuals exposed to severe air pollution Toxicol. Pathol., 32 2004.
4. Campen, M. J., Nolan, J. P., Schladweiler, M. C., Kodavanti, U. P., Evansky, P. A., Costa, D. L., and Watkinson, W. P., Cardiovascular and thermoregulatory effects of inhaled PM-associated transition metals: a potential interaction between nickel and vanadium sulfate, Toxicol. Sci., 64, 243-252, 2001.
5. Campen, M. J., Nolan, J. P., Schladweiler, M. C., Kodavanti, U. P., Costa, D. L., and Watkinson, W. P., Cardiac and thermoregulatory effects of instilled particulate matter-associated transition metals in healthy and cardiopulmonary-compromised rats, J. Toxicol. Environ. Health A, 65, 1615-1631, 2002.
6. Chen, L. C. and Nadziejko, C., Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. V. CAPs exacerbate aortic plaque development in hyperlipidemic mice, Inhal. Toxicol., 17, 217-224, 2005.
7. Donaldson, K. and Borm, P. J., The quartz hazard: a variable entity 7, Ann. Occup. Hyg., 42, 287-294, 1998.
8. Donaldson, K. and Tran, C. L., Inflammation caused by particles and fibers, Inhal. Toxicol., 14, 2002.
9. Donaldson, K. and Tran, C. L., An introduction to the short-term toxicology of respirable industrial fibers, Mutat. Res., 553, 5-9, 2004.
10. Donaldson, K., Stone, V., Borm, P. J., Jimenez, L. A., Gilmour, P. S., Schins, R. P., and Knaapen, A. M. et al., Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM(10)), Free Radic. Biol. Med., 34, 1369-1382, 2003.
11. Donaldson, K., Jimenez, L. A., Rahman, I., Faux, S. P., MacNee, W., Gilmour, P. S., Borm, P. J., Schins, R. P. F., Shi, T., and Stone, V., Respiratory health effects of ambient air pollution particles: role of reactive species, In Oxygen/Nitrogen Radicals: Lung Injury and Disease, Vallyathan, V., Shi, X., and Castranova, V., eds., Marcel Dekker, New York, 2004a. Volk 187 in Lung Biology in Health and Disease, Exec. Ed., Lenfant, C.
12. Donaldson, K., Stone, V., Tran, C. L., Kreyling, W., and Borm, P. J., Nanotoxicology, Occup. Environ. Med, 61, 727-728, 2004b.
13. Donaldson, K., Tran, L., Jimenez, L., Duffin, R., Newby, D. E., Mills, N., MacNee, W., and Stone, V., Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure, Part. Fiber Toxicol, 2, 10, 2005a.
14. Donaldson, K., Tran, L., Jimenez, L. A., Duffin, R., Newby, D. E., Mills, N., MacNee, W., and Stone, V., Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure, Part. Fiber Toxicol, 2, 10, 2005b.
15. Gehr, P., Brand, P., and Heyder, J., Particle deposition in the respiratory tract, In Particle Lung Cell Interactions. Gehr, P. and Heyder, J., eds., Vol. 143, Marcel Dekker, New York, 229-322, 2000.
16. Lung Biology in Health and Disease, Executive Editor, Lenfant, C., Ref Type: Generic Hoet, P. H., Nemmar, A., and Nemery, B., Health impact of nanomaterials? 12, Nat. Biotechnol., 22, 19, 2004.
17. Hussain, S. M., Hess, K. L., Gearhart, J. M., Geiss, K. T., and Schlager, J. J., In vitro toxicity of nanoparticles in BRL 3A rat liver cells 1, Toxicol. In Vitro, 19, 975-983, 2005.
18. Jimenez, L. A., Thompson, J., Brown, D. A., Rahman, I., Antonicelli, F., Duffin, R., Drost, E. M., Hay, R. T., Donaldson, K., and MacNee, W., Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation, Toxicol. Appl. Pharmacol., 166, 101-110, 2000.
19. Knaapen, A. M., Albrecht, C., Becker, A., Hohr, D., Winzer, A., Haenen, G. R., Borm, P. J., and Schins, R. P., DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation, Carcinogenesis, 23, 1111-1120, 2002.
20. Knaapen, A. M., Borm, P. J., Albrecht, C., and Schins, R. P., Inhaled particles and lung cancer. Part A: mechanisms, Int. J. Cancer, 109, 799-809, 2004.
21. Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., and Alyautdin, R., Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier, J. Drug Target., 10, 317-325, 2002.
22. Kreyling, W., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Oberdörster, G., and Ziesenis, A., Minute translocation of inhaled ultrafine insoluble iridium particles from lung epithelium to extrapulmonary tissues, Ann. Occup. Hyg., 46 (suppl.1), 223-226, 2002a.
23. Kreyling W. G., Semmler M., Erbe F., Mayer P., Takenaka, S., Shculz H., Oberdörster, G., and Ziesenis A., Ultrafine insoluble iridium particles are negligibly translocated from the lung epithelium to extrapulmonary organs, 2002b.
24. Lloyd, D. R., Carmichael, P. L., and Phillips, D. H., Comparison of the formation of 8-hydroxy-20-deoxyguanosine and single- and double-strand breaks in DNA mediated by fenton reactions, Chem. Res. Toxicol., 11, 420-427, 1998.
25. Lund, L. G. and Aust, A. E., Iron-catalyzed reactions may be responsible for the biochemical and biological effects of asbestos 7, Biofactors, 3, 83-89, 1991.
26. Maeng, S. H., Chung, H. W., Yu, I. J., Kim, H. Y., Lim, C. H., Kim, K. J., Kim, S. J., Ootsuyama, Y., and Kasai, H., Changes of 8-OH-dG levels in DNA and its base excision repair activity in rat lungs after inhalation exposure to hexavalent chromium, Mutat. Res., 539, 109-116, 2003.
27. Manna, S. K., Sarkar, S., Barr, J., Wise, K., Barrera, E. V., Jejelowo, O., Rice-Ficht, A. C., and Ramesh, G. T., Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factorkappaB in human keratinocytes 1, Nano. Lett., 5, 1676-1684, 2005.
28. Mills, N. L., Tornqvist, H., Robinson, S. D., Gonzalez, M., Darnley, K., MacNee, W., and Boon, N. A. et al., Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis 1 Circulation, 12, 3930-3936, 2005.
29. Molinelli, A. R., Madden, M. C., McGee, J. K., Stonehuerner, J. G., and Ghio, A. J., Effect of metal removal on the toxicity of airborne particulate matter from the Utah Valley, Inhal. Toxicol., 14, 1069-1086, 2002.
30. Morgan, W. K. C. and Seaton, A., Occupational Lung Diseases, Saunders, Philadelphia PA, 1995. Ref Type: Generic.
31. Nemmar, A., Vanbilloen, H., Hoylaerts, M. F., Hoet, P. H., Verbruggen, A., and Nemery, B., Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster, Am. J. Respir. Crit. Care Med., 164, 1665-1668, 2001.
32. Nemmar, A., Hoylaerts, M. F., Hoet, P. H., and Nemery, B., Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects, Toxicol. Lett., 149, 243-253, 2004.
33. Oberdörster, G., Sharp, Z., Elder, A. P., Gelein, R., Kreyling, W., and Cox, C., Translocation of inhaled ultrafine particles to the brain, Inhal. Toxicol., 16, 437-445, 2004.
34. Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., and Carter, J. et al., Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy 1 Part. Fiber Toxicol., 2 2005a.
35. Oberdörster, G., Oberdörster, E., and Oberdörster, J., Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles, Environ. Health Perspect, 113, 823-839, 2005b.
36. Piette, J., Piret, B., Bonizzi, G., Schoonbroodt, S., Merville, M. P., Legrand, P., and Bours, V., Multiple redox regulation in NF-kappaB transcription factor activation, Biol. Chem., 378, 1237-1245, 1997. [Review] [86 refs].
37. Piguet, P. F., Collart, M. A., Grau, G. E., Sappino, A. P., and Vassalli, P., Requirement of tumornecrosis-factor for development of silica- induced pulmonary fibrosis, Nature, 344, 245-247, 1990.
38. Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., and Godleski, J., Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease, Circulation, 109, 71-77, 2003.
39. Pope, C. A. and Dockery, D. W., Epidemiology of particle effects, In Air Pollution and Health. Holgate, S. T., Samet, J. M., Koren, H. S., and Maynard, R. L., eds., Academic Press, San Diego CA, 673-705, 1999.
40. Rahman, I. and MacNee, W., Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches, Free Radic. Biol. Med., 28, 1405-1420, 2000.
41. Sayes, C. M., Gobin, A. M., Ausman, K. D., Mendez, J., West, J. L., Colvin, V. L., Nano-C(60) cytotoxicity is due to lipid peroxidation, Biomaterials, 2005.
42. Schaumann, F., Borm, P. J., Herbrich, A., Knoch, J., Pitz, M., Schins, R. P., Luettig, B., Hohlfeld, J. M., Heinrich, J., and Krug, N., Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects 1, Am. J. Respir. Crit. Care Med., 170, 898-903, 2004.
43. Schins, R. P. F. and Donaldson, K., Nuclear factor kappa B activation by particles and fibers, Inhal. Toxicol., 12 (suppl. 3), 317-326, 2000. Ref Type: Generic.
44. Squadrito, G. L., Cueto, R., Dellinger, B., and Pryor, W. A., Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter, Free Radic. Biol. Med., 31, 1132-1138, 2001.
45. Sun, Q., Wang, A., Jin, X., Natanzon, A., Duquaine, D., Brook, R. D., and Aguinaldo, J. G. et al., Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model 1 JAMA, 294 2005.
46. Suwa, T., Hogg, J. C., Quinlan, K. B., Ohgami, A., Vincent, R., and van Eeden, S. F., Particulate air pollution induces progression of atherosclerosis, J. Am. Coll. Cardiol., 39, 935-942, 2002.
47. Tao, F., Gonzalez-Flecha, B., and Kobzik, L., Reactive oxygen species in pulmonary inflammation by ambient particulates, Free Radic. Biol. Med., 35, 327-340, 2003.
48. Tsurudome, Y., Hirano, T., Yamato, H., Tanaka, I., Sagai, M., Hirano, H., Nagata, N., Itoh, H., and Kasai, H., Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles, Carcinogenesis, 20, 1573-1576, 1999.
49. Vallyathan, V., Castranova, V., Pack, D., Leonard, S., Hubbs, A., Shumaker, J., Ducatman, B., et al., Potential role of free-radicals in acute silicosis, Faseb J, 8, A, 1994.