Synyhesis and anti-hepatitis C virus activity of morpholino triazine derivatives

Heterocycles

Volumn 81, Issue 6, 2010, Pages 1419-1428

  Misawa, Takashi ^a   Salim, Mohammed T A ^b   Okamoto, Mika ^b   Baba, Masanori ^b   Aoyama, Hiroshi ^a   Hashimoto, Yuichi ^a   Sugita, Kazuyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Diphenylmethane; HCV; Multi Template; Replicon; Triazine

Indexed keywords

EID: 77957332981     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/COM-10-11961     Document Type: Article

References (19)

1. T.J. Liang, B. Rehermann, L.B. Seeff, and J.H. Hoofnagle Ann. Intern. Med. 132 2000 296
2. P.H. Hayashi, and A.M. Di Bisceglie Med. Clin. North Am. 89 2005 371
3. J.M. Echevarria-Mayo Enferm. Infecc. Microbiol. Clin. 24 2006 45
4. F.X. Bosch, J. Ribes, R. Cleries, and M. Diaz Clin. Liver Dis. 9 2005 191
5. M.I. Memon, and M.A. Memon J. Viral Hepat. 9 2002 84
6. J.G. McHutchison, S.C. Gordon, E.R. Schiff, M.L. Shiffman, W.M. Lee, V.K. Rustgi, Z.D. Goodman, M.H. Ling, S. Cort, and J.K. Albrecht N. Engl. J. Med. 339 1998 1485
7. Y. Hashimoto Arch. Pharm. Life Sci. 341 2008 536
8. S. Hosoda, D. Matsuda, H. Tomoda, and Y. Hashimoto Mini-Rev. Med. Chem. 9 2009 572
9. S. Hosoda, H. Aoyama, Y. Goto, M.T.A. Salim, M. Okamoto, M. Hashimoto, M. Baba, and Y. Hashimoto Bioorg. Med. Chem. Lett. 19 2009 3157
10. M. Nakamura, T. Hamasaki, M. Tokitou, M. Baba, Y. Hashimoto, and H. Aoyama Bioorg. Med. Chem. 17 2009 4740
11. S. Hosoda, D. Matsuda, H. Tomoda, M. Hashimoto, H. Aoyama, and Y. Hashimoto Bioorg. Med. Chem. Lett. 19 2009 4228
12. Y. Hashimoto Curr. Med. Chem. 5 1998 163
13. Y. Hashimoto Bioorg. Med. Chem. 10 2002 461
14. Y. Hashimoto Mini-Rev. Med. Chem. 2 2002 543
15. Y. Hashimoto, A. Tanatani, K. Nagasawa, and H. Miyachi Drugs. Future 29 2004 383
16. Y. Hashimoto Cell Biol. Rev. 25 1991 209
17. M. Nakamura, A. Aoyama, M.T.A. Salim, M. Okamoto, M. Baba, H. Miyachi, and Y. Hashimoto Bioorg. Med. Chem. 2010 doi: 10.1016/j.bmc.2010.02.057
18. 3) δ: 3.733.81 (4H, m), 3.88 (3H, s), 3.913.98 (4H, m), 4.04 (2H, s), 7.05 (1H, dd, J=7.3, 2.0 Hz), 7.23 (1H, t, J=7.9 Hz), 7.31 (2H, t, J=7.3 Hz), 7.36 (1H, t, J=7.9 Hz), 7.43 (2H, d, J=7.9 Hz)
19. N. Ishii, K. Watashi, T. Hishiki, K. Goto, D. Inoue, M. Hijikata, T. Wakita, N. Kato, and K. Shimotohno J. Virol. 80 2006 4510