Schistosomula, pre-adults and adults of Schistosoma mansoni ingest fluorescence-labelled albumin in vitro and in vivo: Implication for a drug-targeting model

Parasitology

Volumn 137, Issue 11, 2010, Pages 1645-1652

  Holtfreter, M C ^a   Loebermann, M ^a   Frei, E ^b   Riebold, D ^a   Wolff, D ^c   Hartung, G ^d   Kinzelbach, R ^a   Reisinger, E C ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^d KLINIKUM OLDENBURG   (Germany)

Author keywords

adults; aminofluorescein; drug targeting; human serum albumin; ingestion; pre adults; Schistosoma mansoni; schistosomula

Indexed keywords

ALBUMIN CONJUGATE; HUMAN SERUM ALBUMIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; CECUM; ESOPHAGUS; FLUORESCENCE; FLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMULUM; TREMATODE LIFE CYCLE STAGE; WORM;

ANIMALS; ANIMALS, OUTBRED STRAINS; ANTHELMINTICS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; FEMALE; FLUORESCEIN; HUMANS; LUNG; MICE; MICROSCOPY, FLUORESCENCE; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SERUM ALBUMIN; SKIN;

MAMMALIA; MUS; SCHISTOSOMA; SCHISTOSOMA MANSONI; SCHISTOSOMATIDAE;

EID: 77957316908     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182010000405     Document Type: Article

References (28)

1. Barros, L. A., Neves, R. H., De Moura E. G. and Machado-Silva, J. R. (2009). Effects of low-protein diet on Schistosoma mansoni morphology visualized by morphometry and confocal laser scanning microscopy. Journal of Helminthology 83, 13-21.
2. Bennett, M. W. and Caulfield, J. P. (1991). Schistosoma mansoni: ingestion of dextrans, serum albumin, and IgG by schistosomula. Experimental Parasitology 73, 52-61.
3. Bogers, J. J. P. M., Nibbeling, H. A. M., Van Marck, E. A. E. and Deeler, A. M. (1994). Immunofluorescent visualization of the excretory and gut system of Schistosoma mansoni by confocal laser scanning microscopy. The American Journal of Tropical Medicine and Hygiene 50, 612-619.
4. Bogitsh, B. J. (1989). Observations on digestion in schistosomes or "Blood and guts". Transactions of the American Microscopical Society 108, 1-5.
5. Bolling, C., Graefe, T., Lübbing, C., Jankevicius, F., Uktveris, S., Cesas, A., Meyer-Moldenhauer, W. H., Starkmann, H., Weigel, M., Burk, K. and Hanauske, A. R. (2006). Phase II study of MTX-HSA in combination with Cisplatin as first line treatment in patients with advanced or metastatic transitional cell carcinoma. Investigational New Drugs 24, 521-527.
6. Clegg, J. A. (1965). In vitro cultivation of Schistosoma mansoni. Experimental Parasitology 16, 133-147.
7. Crabtree, J. E. and Wilson, R. A. (1980). Schistosoma mansoni: a scanning electron microscope study of the developing schistosomulum. Parasitology 81, 553-564.
8. Delcroix, M., Sajid, M., Caffrey, C. R., Lim, K. C., Dvorak, J., Hsieh, I., Bahgat, M., Dissous, C. and McKerrow, J. H. (2006). A multienzyme network functions in intestinal protein digestion by a plathyhelminthic parasite. The Journal of Biological Chemistry 281, 39316-39329.
9. El-Ridi, R., Ozaki, T., Inaba, T., Ito, M. and Kamiya, H. (1997). Schistosoma mansoni oviposition in vitro reflects worm fecundity in vivo: individual-, parasite age-and host-dependent variations. International Journal for Parasitology 27, 381-387.
10. Fripp, P. J. (1967). The sites of (1-14C) glucose assimilation in Schistosoma haematobium. Comparative Biochemistry and Physiology 23, 893-898.
11. Furlong, S. T., Thibault, K. S. and Rogers, R. A. (1992). Fluorescent phospholipids preferentially accumulate in sub-tegumental cells of schistosomula of Schistosoma mansoni. Journal of Cell Science 103, 823-830.
12. Halton, D. W. (1997). Nutritional adaptations to parasitism within the plathyhelminths. International Journal for Parasitology 27, 693-704.
13. Hartung, G., Stehle, G., Sinn, H., Wunder, A., Schrenk, H. H., Heegers, S., Kranzle, M. E. L., Frei, E., Fiebig, H. H., Heene, D. L., Maier-Borst, W. and Queisser, W. (1999). Phase I trial of methotrexate-albumin in a weekly intravenous bolus regimen in cancer patients. Phase I study group of the Association for Medical Oncology of the German Cancer Society. Clinical Cancer Research 5, 753-759.
14. Kusel, J. R., Oliveira, F. A., Todd, M., Ronketti, F., Lima, S. F., Mattos, A. C. A., Reis, K. T., Coelho, P. M. Z., Thornhill, J. A. and Ribeiro F. (2006). The effects of drugs, ions, and poly-l-lysine on the excretory system of Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz 101, 293-298.
15. Lademann, M., Burchard, G. D. and Reisinger, E. C. (2000). Schistosomiasis and travel medicine. European Journal of Medical Research 5, 405-410.
16. Lawrence, J. D. (1973). The ingestion of red blood cells by Schistosoma mansoni. The Journal of Parasitology 59, 60-63.
17. Miller, P. and Wilson, R. A. (1978). Migration of the schistosomula of Schistosoma mansoni from skin to the lungs. Parasitology 77, 281-302.
18. Neves, R. H., Machado-Silva, J. R., Pelajo-Machado, M., Oliviera, S. A., Coutino, E. M., Lenzi, H. L. and Gomes, D. C. (2001). Morphological aspects of Schistosoma mansoni adult worms isolated from nourished and undernourished mice: a comparative analysis by confocal laser scanning microscopy. Memórias do Instituto Oswaldo Cruz 96, 1013-1016.
19. Ramalho-Pinto, F. J., Gazzinelli, G., Howells, R. E., Mota-Santos, T. A., Figueiredo, E. A. and Pelliogrino, J. (1974). Schistosoma mansoni: defined medium for stepwise transformation of cercariae to schistosomula in vitro. Experimental Parasitology 50, 369-383.
20. Sato, H., Kusel, J. R. and Thornhill, J. (2004). Excretion of fluorescent substrates of mammalian multidrug resistance-associated protein (MRP) in the Schistosoma mansoni excretory system. Parasitology 128, 43-52.
21. Silva, L. M., Menezes, R. M. C., Andrade deOliveira, S. and Andrade, Z. A. (2003). Chemotherapeutic effect on larval stages of Schistosoma mansoni during infection and re-infection of mice. Revista da Sociedade Brasileira de Medicina Tropical 36, 335-341.
22. Skelly, P. J., Tielens, A. G. M. and Shoemaker, C. B. (1998). Glucose transport and metabolism in mammalian stage schistosomes. Parasitology Today 14, 402-406.
23. Tan, H. H. C., Thornhill, J. A., Al-Adhami, B. H., Akhkha, A. and Kusel, J. R. (2003). A study of the effect of surface damage on the uptake of Texas Red-BSA by schistosomula of Schistosoma mansoni. Parasitology 126, 235-240.
24. Uglem, G. L. and Read, C. P. (1976). Sugar transport and metabolism in Schistosoma mansoni. The Journal of Parasitology 61, 390-397.
25. Vis, A. N., van der Gaast, A., van Rhijn, B. W., Catsburg, T. K., Schmidt, T. C. and Mickisch, G. H. J. (2002). A phase II trial of methotrexate-human serum albumin (MTX-HSA) in patients with metastatic renal cell carcinoma who progressed under immunotherapy. Cancer Chemotherapy and Pharmacology 49, 342-345.
26. Wippersteg V., Ribeiro, F., Liedtke, S., Kusel, J. R. and Grevelding, C. G. (2003). The uptake of Texas Red-BSA in the excretory system of schistosomes and its colocalisation with ER60 promotor-induced GFP in transiently transformed adult males. International Journal for Parasitology 33, 1139-1143.
27. Wolff, D., Frei, E., Hofmeister, N., Steiner, B., Kleine, H. D., Junghanss, C., Sievert, K., Terpe, H., Schrenk, H. H., Freund, M. and Hartung, G. (2006). Methotrexate-albumin and aminopterin-albumin effectively prevent experimental acute graft-versus-host disease. Transplantation 82, 527-533.
28. Wunder, A., Mü ller-Ladner, U., Stelzer, E. H., Funk, J., Neumann, E., Stehle, G., Pap, T., Sinn, H., Gay, S. and Fiehn, C. (2003). Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis. Journal of Immunology 170, 4793-4801.