Assessment of erythromycin toxicity on activated sludge via batch experiments and microscopic techniques (epifluorescence and CLSM)

Process Biochemistry

Volumn 45, Issue 11, 2010, Pages 1787-1794

  Louvet, Jean Noël ^a   Heluin, Yannick ^a   Attik, Ghania ^a,b   Dumas, Dominique ^b   Potier, Olivier ^a   Pons, Marie Noëlle ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Antibiotic; BacLight; Inhibition; Macrolides; Microscopy

Indexed keywords

ACTIVATED SLUDGE; ANTIBIOTIC CONCENTRATION; BACLIGHT; BACTERIAL VIABILITY; BATCH EXPERIMENTS; BRIGHT-FIELD MICROSCOPY; CONFOCAL LASER SCANNING MICROSCOPY; EPIFLUORESCENCES; EXPOSURE-TIME; HETEROTROPHIC BACTERIAS; IN-CONTROL; INHIBITION; LATENCY TIME; MACROLIDES; MICRO REACTOR; MICROSCOPE SLIDE; MICROSCOPIC STUDY; MICROSCOPIC TECHNIQUES; MICROSCOPY; MOLECULAR PROBES; THREE-DIMENSIONAL STRUCTURE;

ANTIBIOTICS; BACTERIOLOGY; CONCENTRATION (PROCESS); CONFOCAL MICROSCOPY; EXPERIMENTS; METABOLITES; VISUALIZATION;

TOXICITY;

BACTERIA (MICROORGANISMS);

EID: 77957302596     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2010.03.036     Document Type: Article

References (29)

1. Lienert J., Güdel K., Escher B.I. Screening method for ecotoxicological hazard assessment of 42 pharmaceuticals considering human metabolism and excretory routes. Environmental Science and Technology 2007, 41:4471-4478.
2. Focazio M.J., Kolpin D.W., Barnes K.K., Furlong E.T., Meyer M.T., Zaugg S.D., et al. A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States. II. Untreated drinking water sources. Science of the Total Environment 2008, 402:201-216.
3. Lee Y.J., Lee S.E., Lee D.S., Kim Y.H. Risk assessment of human antibiotics in Korean aquatic environment. Environmental Toxicology and Pharmacology 2008, 26:216-221.
4. Isidori M., Lavorgna M., Nardelli A., Pascarella L., Parrella A. Toxic and genotoxic evaluation of six antibiotics on non-target organisms. Science of the Total Environment 2005, 346:87-98.
5. Baquero F., Martinez J.L., Canton R. Antibiotics and antibiotic resistance in water environments. Current Opinion in Biotechnology 2008, 19:260-265.
6. Kümmerer K. Antibiotics in the aquatic environment-a review. Part II. Chemosphere 2009, 75:435-441.
7. Al-Ahmad A., Haiβ A., Unger J., Brunswick-Tietze A., Wiethan J., Kümmerer K. Effects of a realistic mixture of antibiotics on resistant and nonresistant sewage sludge bacteria in laboratory-scale treatment plants. Archives of Environmental Contamination and Toxicology 2009, 2:264-273.
8. Amann R., Lemmer H., Wagner M. Monitoring the community structure of wastewater treatment plants: a comparison of old and new techniques. FEMS Microbiology Ecology 1998, 25:205-215.
9. Tomlinson T.G., Boon A.G., Trotman N.A. Inhibition of nitrification in the activated sludge process of sewage disposal. Journal of Applied Bacteriology 1966, 29(2):266-291.
10. Schuster A., Hädrich C., Kümmerer K. Flows of active pharmaceutical ingredients originating from health care practices on a local, regional, and nationwide level in Germany. Is hospital effluent treatment an effective approach for risk reduction?. Water, Air, and Soil Pollution 2008, 8:457-471.
11. Kümmerer K. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources-a review. Chemosphere 2001, 45:957-969.
12. Kümmerer K. Antibiotics in the aquatic environment-a review. Part I. Chemosphere 2009, 75:417-434.
13. Hartmann A., Alder A.C., Koller T., Widmer R.M. Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater. Environmental Toxicology and Chemistry 1998, 17:377-382.
14. Larsson D.G.J., de Pedro C., Paxeus N. Effluent from drug manufactures contains extremely high levels of pharmaceuticals. Journal of Hazardous Materials 2007, 148:751-755.
15. Karthikeyan K.G., Meyer M.T. Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA. Science of the Total Environment 2006, 361:196-207.
16. Gulkowska A., Leung H.W., So M.K., Taniyasu S., Yamashita N., Yeung L.W.Y., et al. Removal of antibiotics from wastewater by sewage treatment facilities in Hong Kong and Shenzhen, China. Water Research 2008, 42:395-403.
17. Xu W., Zhang G., Li X., Zouc S., Lia P., Hua Z., et al. Occurrence and elimination of antibiotics at four sewage treatment plants in the Pearl River Delta (PRD), South China. Water Research 2007, 41:4526-4534.
18. Spongberg A.L., Witter J.D. Pharmaceutical compounds in the wastewater process stream in Northwest Ohio. Science of the Total Environment 2008, 397:148-157.
19. Göbel A., Thomsen A., Mcardell C.S., Joss A., Giger W. Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment. Environmental Science and Technology 2005, 39:3981-3989.
20. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environmental Science and Technology 2002, 36:1202-1211.
21. Da Motta M., Pons M.N., Roche N., Vivier H. Characterization of activated sludge by automated image analysis. Biochemical Engineering Journal 2001, 9:165-173.
22. Lopez C., Pons M.N., Morgenroth E. Evaluation of microscopic techniques (epifluorescence microscopy, CLSM, TPE-LSM) as a basis for the quantitative image analysis of activated sludge. Water Research 2005, 39:456-468.
23. Molecular Probes, LIVE/DEAD® BacLight™ Bacterial Viability Kits. Fluorescence Spectroscopy Protocols. Staining Bacteria with either Kit L7007 or L7012. Revised: 15 July; 2004.
24. Alighardashi A., Pandolfi D., Potier O., Pons M.N. Acute sensitivity of activated sludge bacteria to erythromycin. Journal of Hazardous Materials 2009, 172:685-692.
25. Louvet J.N., Giammarino C., Potier O., Pons M.N. Adverse effects of erythromycin on the structure and chemistry of activated sludge. Environmental Pollution 2010, 158:688-693.
26. 2O on carbon and nutrients removal and on resistance selection in sequencing batch reactors (SBRs). Environmental Biotechnology 2009, 85:185-195.
27. Fernández I., Mosquera-Corral A., Campos J.L., Méndez R. Operation of an Anammox SBR in the presence of two broad-spectrum antibiotics. Process Biochemistry 2009, 44:494-498.
28. Gião M.S., Wilks S.A., Azevedo N.F., Vieira M.J., Keevil C.W. Validation of SYTO 9/propidium iodide uptake for rapid detection of viable but noncultivable Legionella pneumophila. Microbial Ecology 2009, 58:56-62.
29. Chu C.P., Lee D.J., Tay J.H. Floc model and intrafloc flow. Chemical Engineering Science 2005, 60:565-575.