Polypharmacy and pain treatment;Polypharmazie und Schmerztherapie

Wiener Medizinische Wochenschrift

Volumn 160, Issue 11-12, 2010, Pages 286-292

  Gosch, Markus ^a   Böhmdorfer, Birgit ^b   Benvenuti Falger, Ursula ^a   Dovjak, Peter ^c   Iglseder, Bernhard ^d   Lechleitner, Monika ^a   Otto, Ronald ^e   Roller, Regina E ^e   Sommeregger, Ulrike ^b  

^a Hospital Hochzirl   (Austria)

^b Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhugel   (Austria)

^c Abteilung fur Akutgeriatrie/Remobilisation   (Austria)

^d PARACELSUS MEDICAL UNIVERSITY   (Austria)

^e INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Adverse drug effects; Drug interaction; Inappropriate medication; Pain; Polypharmacy

Indexed keywords

ACENOCOUMAROL; AMFEBUTAMONE; AMIODARONE; ANTIVITAMIN K; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAMAZEPINE; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPYRONE; EFAVIRENZ; GLIBENCLAMIDE; IBUPROFEN; IFOSFAMIDE; METHADONE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; ONDANSETRON; OPIATE DERIVATIVE; PARACETAMOL; PAROXETINE; PETHIDINE; PHENACETIN; PHENPROCOUMON; QUINOLONE; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRAMADOL; UNINDEXED DRUG; WARFARIN;

ARTICLE; CARDIOVASCULAR RISK; CHRONIC PATIENT; DRUG CLEARANCE; DRUG POTENTIATION; GENETIC POLYMORPHISM; GERIATRIC DISORDER; HEALTH HAZARD; HUMAN; LIVER TOXICITY; PAIN; POLYPHARMACY; SEDATION; SEROTONIN SYNDROME; WORLD HEALTH ORGANIZATION;

EID: 77957299367     PISSN: 00435341     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10354-010-0788-z     Document Type: Article

References (69)

1. HD Basler S Hesselbarth M Schuler 2004 Schmerzdiagnostik und -therapie in der Geriatrie. Teil 1 Schmerzdiagnostik. Schmerz 18 317 326 1:STN:280:DC%2BD2cvgsFWlsg%3D%3D
2. MP Davies M Srivastava 2003 Demographics, assessment and management of pain in the elderly Drugs Aging 20 23 57 10.2165/00002512-200320010-00003 (Pubitemid 36127032)
3. T Hadjistavropoulos K Herr DC Turk, et al. 2007 An interdisciplinary expert consensus statement on assessment of pain in older persons Clin J Pain 23 Suppl S1 S43 10.1097/AJP.0b013e31802be869 17179836 (Pubitemid 46006259)
4. GP Stoehr M Ganguli EC Seaberg, et al. 1997 Over-the-counter medication use in an older rural community: the MoVIES Project J Am Geriatr Soc 45 158 165 1:STN:280:DyaK2s7osFygsA%3D%3D 9033513 (Pubitemid 27066524)
5. D Rottlaender M Scherner T Schneider, et al. 2007 Multimedikation, Compliance und Zusatzmedikation bei Patienten mit kardiovaskulären Erkrankungen Dtsch Med Wochenschr 132 139 144 10.1055/s-2007-959300 1:STN:280:DC%2BD2s%2Fjt1aitA%3D%3D 17230328 (Pubitemid 46405884)
6. U Junius Walker G Theile E Hummers-Pradier 2007 Prevalence and predictors of polypharmacy among older primary care patients in Germany Fam Pract 24 14 19 10.1093/fampra/cml067 1:STN:280:DC%2BD2s7ltlyrsQ%3D%3D 17164234 (Pubitemid 46454660)
7. P Sawyer EV Bodner CS Ritchie, et al. 2006 Pain and pain medication use in community-dwelling older adults Am J Geriatr Pharmacother 4 316 324 10.1016/j.amjopharm.2006.12.005 17296537 (Pubitemid 46211184)
8. M Pirmohamed S James S Meakin, et al. 2004 Adverse drug reactions as cause of admission to hospital: prospective analysis of 18820 patients BMJ 329 15 10.1136/bmj.329.7456.15 15231615
9. M Laroche J Charmes Y Nouaille, et al. 1997 Is inappropriate medication use a major cause of adverse drug reactions in the elderly Br J Clin Pharmacol 63 177 186 10.1111/j.1365-2125.2006.02831.x
10. DH Solomon J Avorn JN Katz, et al. 2005 Compliance with osteoporosis medications Arch Intern Med 165 2414 2419 10.1001/archinte.165.20.2414 16287772 (Pubitemid 41640855)
11. J Schuler C Dückelmann W Beindl, et al. 2008 Polypharmacy and inappropriate prescribing in elderly internal-medicine patients in Austria Wien Klin Wochenschr 120 733 741 10.1007/s00508-008-1089-z 19122984
12. HP Wirth R Hürlimann T Flückiger 2006 NSAR und Cox-2-Hemmer: die häufigsten unerwünschten Wirkungen Schweiz Med Forum 6 284 289
13. G Onder C Pedone F Landi, et al. 2002 Adverse drug reactions as cause of hospital admissions: Results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA) JAGS 50 1962 1968 10.1046/j.1532-5415.2002.50607.x (Pubitemid 35462441)
14. ATC-DDD system (online), available from URL: http://www.whocc.no/atcddd/ atsystem.html#6 (assessed 18 February 2008)
15. A Baraldi M Ballestri R Rapana, et al. 1998 Acute renal failure of medical type in an elderly population Nephrol Dial Transplant 13 Suppl 7 25 29 10.1093/ndt/13.suppl-7.25 9870433
16. HL Smets JF De Haes A De Swaef, et al. 2008 Exposure of the elderly to potential nephrotoxic drug combinations in Belgium Pharmacoepidemiol Drug Saf 17 1014 1019 10.1002/pds.1641 18763247
17. J Page D Henry 2000 Consumption of NSAIDs and the development of congestive heart failure in elderly patients: an underecognized public health problem Arch Intern Med 160 777 784 10.1001/archinte.160.6.777 1:CAS:528:DC%2BD3cXisVClsbc%3D 10737277
18. AG Johnson 1997 NSAIDs and increased blood pressure. What is clinical significance? Drug Saf 17 277 289 10.2165/00002018-199717050-00001 1:CAS:528:DyaK2sXns1OhtbY%3D 9391772
19. AG Johnson TV Nguyan RO Day 1994 Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis Ann Intern Med 121 289 300 1:STN:280:DyaK2czhtFGnsg%3D%3D 8037411
20. PW de Leeuw 1996 Nonsteriodal anti-inflammatory drugs and hypertension. The risk in perspective Drugs 51 179 187 10.2165/00003495-199651020-00001 1:CAS:528:DyaK28Xhtlyku78%3D 8808162
21. TM MacDonald L Wie 2003 Effect of ibuprufen on cardioprotective effect of aspirin Lancet 361 573 574 10.1016/S0140-6736(03)12509-3 1:CAS:528: DC%2BD3sXht1Gitbo%3D 12598144 (Pubitemid 36207477)
22. L Garcia-Rodriguez C Varas-Lorenzo A Maguire, et al. 2004 Nonsteroidal antiinflammatory drugs and the risk of myocardial infarction in the general population Circulation 109 3000 3006 10.1161/01.CIR.0000132491.96623.04 1:CAS:528:DC%2BD2cXltVCjsbs%3D 15197149 (Pubitemid 38808323)
23. JA Delaney L Opatrny JM Brophy, et al. 2007 Drug-drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding CMAJ 177 347 351 17698822
24. BP Skop TM Brown 1996 Potential bleeding complications of treatment with selective serotonin reuptake inhibitors Psychosomatics 37 12 16 1:CAS:528:DyaK28XlvVCrtbg%3D 8600488
25. Verbeuren TJ. Synthesis, storage, release and metabolism of 5-hydroxyltryptamine in peripheral tissues. In: Fozard JR (ed) The Peripheral Actions of 5-hydroxyltryptamine. New York, NY: Oxford University Press, pp 1-25, 1989
26. F De Clerck 1990 The role of serotonin in thrombogenesis Clin Physiol Biochem 8 Suppl 3 40 49 1966729
27. YK Loke AN Trivel S Ingh 2008 Meta-analysis: gastrointestinal bleeding due to interaction between selektive serotonin reuptake inhibitors and non steroidal inflammatory drugs Aliment Pharmacol Ther 27 31 40 1:STN:280:DC%2BD2sjjsl2mtQ%3D%3D 17919277
28. R Janknegt 1990 Drug interactions with quinolones J Antimicrob Chemoter 26 Suppl D 7 29 1:CAS:528:DyaK3MXhtFCnt7k%3D
29. Iqbal Z, Khan A, Naz A, et al. Pharmacokinetic interaction of ciprofloxacin with diclofenac: a single dose, two-period crossover study in healthy adult volunteers. Clin Drug Investig, 29: 4, 275-281, 2009
30. P Ball G Tillotson 1996 Tolerability of flouroquinolone antibiotics: past, present and future Drug Saf 13 343 10.2165/00002018-199513060-00004
31. H Sone A Takahashi N Yamada 2001 Ibuprofen-related hypoglycaemia in a patient receiving sulfonylurea Ann Intern Med 134 344 1:STN:280: DC%2BD3M7ktl2qsg%3D%3D 11182854
32. M Collin JC Mucklow 1999 Drug interactions, renal impairment and hypoglycaemia in a patient with Type II diabetes Br J Clin Pharmacol 48 134 137 10.1046/j.1365-2125.1999.00996.x 1:STN:280:DyaK1MzkvVSltg%3D%3D 10417487 (Pubitemid 29349446)
33. RS Sinatra JS Jahr LW Reynolds, et al. 2005 Efficacy and safety of single and repeated administration of 1 gram intravenous acetominophen injection (paracetamol) for pain management after major orthopedic surgery Anesthesiology 102 822 832 10.1097/00000542-200504000-00019 1:CAS:528:DC%2BD2MXis1enur4%3D 15791113 (Pubitemid 40462863)
34. CH Gleiter 1997 Paracetamol - das sichere Analgetikum Internist 38 707 712 10.1007/s001080050083 1:STN:280:DyaK2svgvFCitg%3D%3D 9333609 (Pubitemid 27341551)
35. B Hinz O Cheremina K Brune 2008 Acetaminophen (paracetamol) is a selektive cyclooxygenase-2 inhibitor in man FASEB J 22 383 390 10.1096/fj.07-8506com 1:CAS:528:DC%2BD1cXhvVSqsLc%3D 17884974 (Pubitemid 351225574)
36. A Gonzalez-Perez L Garcia Rodriguez 2006 Upper gastrointestinal complications among users of paracetamol Basic Clin Pharmacol Toxicol 98 297 303 10.1111/j.1742-7843.2006.pto-248.x 1:CAS:528:DC%2BD28XjsVWmsLk%3D 16611205
37. I Mahe N Bertrand L Drouet, et al. 2006 Interaction between paracetamol and warfarin in patients: a double-blind, pacebo-controlled, randomized study Haematologica 91 1621 1627 1:CAS:528:DC%2BD2sXptlemtg%3D%3D 17145598
38. JP Forman MJ Stampfer GC Curhan 2005 Non-narcotic analgesic dose and risk of incident hypertension in US women Hypertension 46 500 507 10.1161/01.HYP.0000177437.07240.70 1:CAS:528:DC%2BD2MXptVWkurc%3D 16103274 (Pubitemid 41376829)
39. AT Chan JE Manson CM Albert, et al. 2006 Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events Circulation 113 1578 1587 10.1161/CIRCULATIONAHA.105.595793 1:CAS:528:DC%2BD28XisFygs7w%3D 16534006 (Pubitemid 43739417)
40. A Larsen J Poison R Fontana, et al. 2005 Acetaminophen-induced acute liver failure: results of a US Multicenter, prospective study Hepatology 42 1364 1372 10.1002/hep.20948 (Pubitemid 43260039)
41. E Perucca A Richens 1979 Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs Br J Clin Pharmacol 7 201 206 1:CAS:528:DyaE1MXhs1ahtLk%3D 760753
42. MJ Toes AL Jones L Prescott 2005 Drug interactions with paracetamol Am J Ther 12 56 66 10.1097/00045391-200501000-00009 15662293 (Pubitemid 40516047)
43. Reinhardt N, Jantos R, Sinning C, et al. Renaissance eines Analgetikums. Pharmazeutische Zeitschrift, 32, 2006 (online)
44. C Campos R de Gregorio R Garcia-Nieto, et al. 1999 Regulation of cyclooxygenase activity by metamizol Eur J Pharmacol 378 339 347 10.1016/S0014-2999(99)00477-X 1:CAS:528:DyaK1MXmtVKiurg%3D 10493111 (Pubitemid 29392936)
45. Verspohl EJ. Analgetika mit antipyretischer und antiphlogistischer Wirkungskomponente. In: Ammon HPT (Hrsg) Arzneimittelneben- und -wechselwirkungen. 4. Auflage, WVG: Stuttgart, pp 420-424, 2001
46. Fachinformation Novalgin®, August 2004. Aventis Pharma
47. M Levy 1986 Risks of agranulocytosis and aplastic anaemia: the international agranulocytosis and aplastic anaemia study J Am Med Assoc 256 1749 1757 10.1001/jama.256.13.1749 (Pubitemid 16025079)
48. Arzneimittelkommission der dt. Ärzteschaft, Arzneiverordnungen. 21. Auflage, pp 214-216, 2006
49. T Saussele O Burk JK Blievernicht, et al. 2007 Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole Clin Pharmacol Ther 83 265 274 10.1038/sj.clpt.6100138 (Pubitemid 47258464)
50. Th Enggaard L Poulsen L Arendt-Nielsen, et al. 2006 The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6 Anesth Analg 102 146 150 10.1213/01.ane.0000189613.61910.32 1:CAS:528:DC%2BD2MXhtlSqurfO 16368820 (Pubitemid 43038298)
51. P Dayer J Desmeules L Collart 1997 Pharmacology of tramadol Drugs 53 Suppl 2 18 24 10.2165/00003495-199700532-00006 1:CAS:528:DyaK2sXislOrtbY%3D 9190321
52. Opioids+benzodiazepines, stockleys drug interactions, medicines complete. In: Baxter K (ed) London, UK: RPS Publishing, http://www.medicinescomplete.com/ mc, 01/08/2008
53. Serotonin reuptake inhibitors/tramadol. In: Tatro DS (ed) Drug Interaction Facts, Facts and Comparisons 4.0. St. Louis, MI, USA: Wolters Kluwer Health Inc., http://online.factsandcomparisons.com, 14/05/2009
54. S Kesavan GM Sobala 1999 Serotonin syndrome with fluoxetine plus tramadol J R Soc Med 92 474 475 1:STN:280:DC%2BD3c7gvFyqug%3D%3D 10645303
55. IW Boyd 2005 Tramadol and seizures Med J Aust 182 595 596 15938692
56. F Pisani G Oteri C Costa, et al. 2002 Effects of psychotropic drugs on seizure threshold Drug Saf 25 91 110 10.2165/00002018-200225020-00004 1:CAS:528:DC%2BD38XivFyjtr8%3D 11888352
57. JA Desmeules 2000 The tramadol option Eur J Pain 4 Suppl A 15 21 1:CAS:528:DC%2BD3MXoslertQ%3D%3D 11310478
58. D Hedges K Jeppson P Whitehead 2003 Antipsychotic medication and seizures: a review Drugs Today 39 551 557 10.1358/dot.2003.39.7.799445 1:CAS:528:DC%2BD3sXosFylu7c%3D 12973403 (Pubitemid 37187418)
59. H Potschka E Friderichs W Loscher 2000 Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy Br J Pharmacol 131 203 212 10.1038/sj.bjp.0703562 1:CAS:528:DC%2BD3cXntlGkur4%3D 10991912
60. Tramadol Hydrochloride, American Hospital Formulary Service Drug Information, Medicines Complete. In: McEvoy GK (ed) London, UK: RPS Publishing, http://www.medicinescomplete.com/mc, 07/07/2008
61. Opioids+Antiepileptics; Enzyme-inducing, Stockleys Drug Interactions, Medicines Complete. In: Baxter K (ed) London, UK: RPS Publishing, http://www.medicinescomplete.com/mc, 15/12/2008
62. R Arcioni M della Rocca S Romanò, et al. 2002 Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans Anesth Analg 94 1553 1557 10.1097/00000539-200206000-00033 1:CAS:528:DC%2BD38XkvFSgur0%3D 12032025
63. JL De Witte B Schoenmaekers DI Sessler, et al. 2001 The analgesic efficacy of tramadol is impaired by concurrent administration of ondansetron Anesth Analg 92 1319 1321 10.1097/00000539-200105000-00045 1:CAS:528: DC%2BD3MXjvValtL0%3D 11323369
64. K Hedenmalm JD Lindh J Sawe, et al. 2004 Increased liability of tramadol-warfarin interaction in individuals with mutations in the cytochrome P450 2D6 gene Eur J Clin Pharmacol 60 369 372 10.1007/s00228-004-0783-7 1:CAS:528:DC%2BD2cXmtFWksLg%3D 15197521
65. JR Sabbe PJ Sims MH Sims 1998 Tramadol-warfarin interaction Pharmacotherapy 18 871 873 1:STN:280:DyaK1czlsFCitw%3D%3D 9692666
66. F Penning-van Beest J Erkens KU Petersen, et al. 2005 Main comedications associated with major bleeding during anticoagulant therapy with coumarins Eur J Clin Pharmacol 61 439 444 10.1007/s00228-005-0947-0 1:CAS:528: DC%2BD2MXmsFWls7c%3D 15947920 (Pubitemid 41569322)
67. ST Rang J Field C Irving 2008 Serotonin toxicity caused by an interaction between fentanyl and paroxetine Can J Anaesth 55 521 525 10.1007/BF03016672 18676387
68. S Ailawadhi KW Sung LA Carlson, et al. 2007 Serotonin syndrome caused by interaction between citalopram and fentanyl J Clin Pharm Ther 32 199 202 10.1111/j.1365-2710.2007.00813.x 1:STN:280:DC%2BD2s7otFOntA%3D%3D 17381671 (Pubitemid 46449708)
69. A Won KL Lapane S Vallow, et al. 2006 Long-term effects of analgesics in a population of elderly nursing home residents with peristent nonmalignant pain J Gerontol A Biol Sci Med Sci 61 165 169 16510860