Long-term outcome in patients with ulcerative colitis treated with intravenous cyclosporine A is determined by previous exposure to thiopurines

Journal of Crohn's and Colitis

Volumn 4, Issue 4, 2010, Pages 398-404

  Walch, Andrea ^a   Meshkat, Miena ^a   Vogelsang, Harald ^a   Novacek, Gottfried ^a   Dejaco, Clemens ^a   Angelberger, Sieglinde ^a   Mikulits, Andrea ^a   Miehsler, Wolfgang ^a   Gangl, Alfred ^a   Reinisch, Walter ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Active ulcerative colitis; Colectomy; Cyclosporine A; Long term outcome; Severe; Thiopurines

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; AZATHIOPRINE; CYCLOSPORIN A; MERCAPTOPURINE;

ADOLESCENT; ADULT; AGED; ARTICLE; COLON RESECTION; DISEASE SEVERITY; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HUMAN; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK REDUCTION; TREATMENT OUTCOME; TREATMENT RESPONSE; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AZATHIOPRINE; COLECTOMY; COLITIS, ULCERATIVE; CYCLOSPORINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PURINES; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TREATMENT FAILURE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77957294640     PISSN: 18739946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.crohns.2010.01.001     Document Type: Article

References (23)

1. Edwards F.C., Truelove S.C. The course and prognosis of ulcerative colitis. Gut 1963, 4:299-315.
2. Turner D., Walsh C.M., Steinhart A.H., Griffiths A.M. Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression. Clin Gastroenterol Hepatol 2007, 5:103-110.
3. Truelove S.C., Willoughby C.P., Lee E.G., Kettlewell M.G. Further experience in the treatment of severe attacks of ulcerative colitis. Lancet 1978, 2:1086-1088.
4. Järnerot G., Rolny P., Sandberg-Gertzén H. Intensive intravenous treatment of ulcerative colitis. Gastroenterology 1985, 89:1005-1013.
5. Travis S.P., Farrant J.M., Ricketts C., Nolan D.J., Mortensen N.M., Kettlewell M.G., et al. Predicting outcome in severe ulcerative colitis. Gut 1996, 38:905-910.
6. Travis S.P.L., Stange E.F., Lémann M., Oresland T., Bemelman W.A., Chowers Y., et al. European evidence-based consensus on the management of ulcerative colitis: current management. J Crohn's Colitis 2008, 2:24-62.
7. Lichtiger S., Present D.H., Kornbluth A., Gelernt I., Bauer J., Galler G., et al. Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med 1994, 330:1841-1845.
8. Arts J., D'Haens G., Zeegers M., Van Assche G., Hiele N., D'Hoore A., et al. Long-term outcome of treatment with intravenous cyclosporin in patients with severe ulcerative colitis. Inflamm Bowel Dis 2004, 10:73-78.
9. Hyde G.M., Thillainayagam A.V., Jewell D.P. Intravenous cyclosporin as rescue therapy in severe ulcerative colitis: time for a reappraisal?. Eur J Gastroenterol Hepatol 1998, 10:411-413.
10. Fernández-Bañares F., Bertrán X., Esteve-Comas M., Cabré E., Menacho M., Humbert P., et al. Azathioprine is useful in maintaining long-term remission induced by intravenous cyclosporine in steroid-refractory severe ulcerative colitis. Am J Gastroenterol 1996, 91:2498-2499.
11. Cohen R.D., Stein R., Hanauer S.B. Intravenous cyclosporin in ulcerative colitis: a five-year experience. Am J Gastroenterol 1999, 94:1587-1592.
12. Stack W.A., Long R.G., Hawkey C.J. Short- and long-term outcome of patients treated with cyclosporin for severe acute ulcerative colitis. Aliment Pharmacol Ther 1998, 12:973-978.
13. Dejaco C., Gasché C., Reinisch W., Moser G., Novacek G., Tillinger W., et al. Cyclosporine A therapy in steroid-refractory patients with chronic inflammatory bowel disease. Wien Klin Wochenschr 1998, 110:579-584.
14. Van Assche G., D'Haens G., Noman M., Vermeire S., Hiele M., Asnong K., et al. Randomized, double-blind comparison of 4mg/kg versus 2mg/kg intravenous cyclosporine in severe ulcerative colitis. Gastroenterology 2003, 125:1025-1031.
15. Campbell S., Travis S., Jewell D. Ciclosporin use in acute ulcerative colitis: a long-term experience. Eur J Gastroenterol Hepatol 2005, 17:79-84.
16. Moskovitz D.N., Van Assche G., Maenhout B., Arts J., Ferrante M., Vermeire S., et al. Incidence of colectomy during long-term follow-up after cyclosporine-induced remission of severe ulcerative colitis. Clin Gastroenterol Hepatol 2006, 4:760-765.
17. Cacheux W., Seksik P., Lemann M., Marteau P., Nion-Larmurier I., Afchain P., et al. Predictive factors of response to cyclosporine in steroid-refractory ulcerative colitis. Am J Gastroenterol 2008, 103:637-642.
18. Rowe F.A., Walker J.H., Karp L.C., Vasiliauskas E.A., Plevy S.E., Targan S.R. Factors predictive of response to cyclosporin treatment for severe, steroid-resistant ulcerative colitis. Am J Gastroenterol 2000, 95:2000-2008.
19. Lindgren S.C., Flood L.M., Kilander A.F., Löfberg R., Persson T.B., Sjödahl R.I. Early predictors of glucocorticosteroid treatment failure in severe and moderately severe attacks of ulcerative colitis. Eur J Gastroenterol Hepatol 1998, 10:831-835.
20. Poritz L.S., Rowe W.A., Swenson B.R., Hollenbeak C.S., Koltun W.A. Intravenous cyclosporine for the treatment of severe steroid refractory ulcerative colitis: what is the cost?. Dis Colon Rectum 2005, 48:1685-1690.
21. Truelove S.C., Witts L.J. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J 1955, 2:1041-1048.
22. Satsangi J., Silverberg M.S., Vermeire S., Colombel J.F. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006, 55:749-753.
23. Message L., Bourreille A., Laharie D., Quinton A., Galmiche J.P., Lamouleatte H., et al. Efficacy of intravenous cyclosporin in moderately severe ulcerative colitis refractory to steroids. Gastroenterol Clin Biol 2005, 29:231-235.