Cyclosporine in patients with inflammatory bowel disease refractory to steroid therapy;Cyclosporin-A-therapie bei steroidrefraktaren Patienten mit chronisch entzundlichen Darmerkrankungen

Wiener Klinische Wochenschrift

Volumn 110, Issue 16, 1998, Pages 579-584

  Dejaco, Clemens ^a   Gasché, Christoph ^a   Reinisch, Walter ^a   Moser, Gabriele ^a   Novacek, Gottfried ^a   Tillinger, Wolfgang ^a   Vogelsang, Harald ^a   Gangl, Alfred ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Azathioprine; Crohn's disease; Cyclosporine; Ulcerative colitis

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; PREDNISONE; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL ARTICLE; CROHN DISEASE; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MALE; ULCERATIVE COLITIS; DRUG ADMINISTRATION; DRUG COMBINATION; IMMUNOLOGY; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; RECURRENT DISEASE; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; AZATHIOPRINE; COLITIS, ULCERATIVE; CROHN DISEASE; CYCLOSPORINE; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFUSIONS, INTRAVENOUS; PREDNISONE; RECURRENCE; TREATMENT OUTCOME;

EID: 0032483268     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Targan SR, Kagnoff MF, Brogan MD, Shanahan F (1987) Immunologic mechanisms in intestinal diseases. Ann Intern Med 106: 853-870
2. MacDermott RP, Stenson WF (1988) Alterations of the immune system in ulcerative colitis and Crohn's disease. Adv Immunol 42: 285-328
3. Sartor B (1994) Viewpoints on digestive diseases and cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 106: 533-539
4. Shanahan F, Targan SR (1992) Medical treatment of inflammatory bowel disease. Annu Rev Med 43: 125-133
5. Peppercorn MA (1990) Advances in drug therapy for inflammatory bowel disease. Ann Intern Med 112: 50-60
6. Stange E, Schreiber F, Raedler A, Stallmach A, Schölmerich J, Loeschke K, et al (1997) Therapie des Morbus Crohn - Ergebnisse einer Konsensuskonferenz der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten. Z Gastroenterol 35: 541-554
7. Sandborn WJ (1996) A review of immune modifier therapy for inflammatory bowel disease: Azathioprine, 6-Mercaptopurine, Cyclosporine, and Methotrexate. Am J Gastroenterol 91: 423-433
8. Connell WR, Kamm MA, Dickson M, Balkwill AM, Ritchie JK, Lennard-Jones JE (1994) Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease. Lancet 343: 1249-1252
9. Connell WR, Kamm MA, Ritchie JK, Lennard-Jones JE (1993) Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years experience. Gut 34: 1081-1085
10. Ewe K, Press AG, Singe CC, Stufler M, Ueberschaer B, Hommel G, Meyer zum Buschenfelde KH (1993) Azathioprine combined with prednisolone or monotherapy with prednisolone in active Crohn's disease. Gastroenterology 105: 367-372
11. Sandborn WJ, Van O EC, Zins BJ, Tremaine WJ, Mays CD, Lipsky JJ (1995) An intravenous loading dose of azathioprine decreases the time to response in patients with Crohn's disease. Gastroenterology 109: 1808-1817
12. Cohen DJ, Loertscher R, Rubin MF, Tilney NL, Carpenter CB, Strom TB (1984) Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med 101: 667-682
13. Tugwell P, Bombardier C, Gent M, Bennett KJ, Bensen WG, Carette S, et al (1990) Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis. Lancet 335: 1051-1055
14. Ellis CN, Fradin MS, Messana JM, Brown MD, Siegel MT, Hartley AH, et al (1991) Cyclosporin for plaque-type psoriasis: results of a multidose, double-blind trial. N Engl J Med 324: 277-284
15. Masuda K, Nakajima A, Urayama A, Nakae K, Kogure M, Inaba G (1989) Double-masked trial of Cyclosporine in Bechet's disease. Lancet i: 1093-1096
16. Sandborn WJ (1995) A critical review of Cyclosporine therapy in inflammatory bowel disease. Inflammatory Bowel Disease 1: 48-63
17. Santos JV, Baudet JA, Casellas FJ, Guarner LA, Vilaseca JM, Malagelada JR (1995) Intravenous cyclosporine for steroid-refractory attacks of Crohn's disease. Short- and long-term results. J Clin Gastroenterol 20: 207-210
18. Lichtiger S, Present DH, Kornbluth A, Gelernt I, Bauer J, Galler G, Michelassi F, Hanauer S (1994) Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med 330: 1841-1845
19. Best WR, Becktel JM, Singleton JW, Kern F (1976) Development of a Crohn's disease activity index. National Cooperative Crohn's disease Study. Gastroenterology 70: 439-444
20. Rachmilewitz D (1989) Coated mesalazine (5-aminosalicylic acid) versus sulphasalzine in the treatment of active ulcerative colitis: a randomised trial. BJM 298: 82-86
21. Faulds D, Goa KL, Benfield P (1993) Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs 45/6: 953-1040
22. Targan SR, Deem RL, Shanahan F (1991) Role of mucosal T-cell generated cytokines in epithelial cell injury. Immunol Res 10: 472-478
23. Shanahan F, Targan SR (1992) Mechanisms of tissue injury in inflammatory bowel disease. In: Mac Dermott RP, Stenson WF (eds) Inflammatory bowel disease. Elsevier, New York, p77
24. Sartor RB, Bender DE, Allen JB, Zimmermann EM, Holt LC, Pardo MS, et al (1993) Chronic experimental enterocolitis and extraintestinal inflammation are T lymphocyte dependent. Gastroenterology 104: 775A
25. MacDonald TT, Spencer J (1993) Evidence that activated mucosal T-cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med 167: 1341-1349
26. Hess AD, Tutschka PJ, Santos GW (1982) Effect of cyclosporin A on human lymphocyte response in vitro. J Immunol 128: 355-359
27. Liu J, Farmer JD, Lane WS, Friedmann J, Weissman I, Schreiber SL (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815
28. Reed JC, Prystowsky MB, Nowell PC (1988) Regulation of gene expression in lectin-stimulated or lymphokine-stimulated T lymphocytes. Transplantation 46: 85-89
29. Feagen BG, McDonald J, Rochon J, Laupacis A, Fedorak RN, Kinnear D, et al (1994) Low-dose cyclosporine for the treatment of Crohn's disease. N Engl J Med 330: 1846-1851
30. Jewell DP, Lennard-Jones JF., and the cyclosporine study group of Great Britain and Ireland (1994) Oral cyclosporine for chronic active Crohn's disease: a multicenter controlled trial. Eur J Gastroenterol Hepatol 6: 499-505
31. Stange EF, Modigliani R, Pena AS, Wood AJ, Feutren G, Smith PR, and the European study group (1995) European trial of cyclosporine in chronic active Crohn's disease: a 12-month study. Gastroenterology 109: 774-782
32. Brynskov J, Freund L, Norby-Rasmussen S, Lauritsen K, Schaffalitzky de Muckadell O, Williams N, et al (1991) Final report on a placebo-controlled, double-blind, randomized, multicenter trial of cyclosporin treatment in active chronic Crohn's disease. Scand J Gastroenterol 26: 689-695
33. Brynskov J, Freund L, Norby-Rasmussen S, Lauritsen K, Schaffalitzky de Muckadell O, Williams N, et al (1989) A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease. N Engl J Med 321: 845-850
34. Sandborn WJ, Tremaine WJ, Schroeder KW, Batts KP, Lawson GM, Steiner BL, et al (1994) A placebo- controlled trial of cyclosporine enemas for mildly to moderate active left-sided ulcerative colitis. Gastroenterology 106: 1429-1435
35. Fernández-Banares E, Bertrán X, Esteve-Comas M, Cabré E, Menacho M, Humbert P, et al (1996) Azathioprine is useful in maintaining long -term remission introduced by cyclosporine in steroid-refractory severe ulcerative colitis. Am J Gastroenterol 91: 2498-2499
36. Hanauer SB, Smith MB (1996) Rapid closure of Crohn's disease fistulas with continuous intravenous cyclosporin A. Am J Gastroenterol 88: 646-649
37. Hinterleitner T, Petritsch A, Aichbichler W, Fickert B, Ranner P, Krejs GJ (1997) Combination of cyclosporine, azathioprine and prednisolone for perianal fistulas in Crohn's disease. Z Gastroenterol 35: 603-608
38. Palestine AG, Nussenblatt RB, Chan CC (1984) Side effects of systemic cyclosporine in patients not undergoing transplantation. Am J Med 77: 652-656
39. Bencini PL, Montagino G, Sala F, De Vecci A, Crosti C, Tarantino A (1986) Cutaneous lesions in 67 cyclosporin-treated renal transplantation recipients. Dermatologica 172: 24-30
40. Tegzess AM, Doorenbos BM, Minderhound JM, Donker AJ (1988) Prospective serial renal function studies in patients with nonrenal disease treated with cyclosporine A. Transplant Proc 20: 390-393
41. Smith MB, Hanauer SB (1992) Pneumocystis carinii pneumonia during cyclosporine therapy for ulcerative colitis. N Engl J Med 327: 497-498
42. Scalzini A, Barni C, Stellini R, Sueri L (1995) Fatal invasive aspergillosis during cyclosporine and steroid treatment for Crohn's disease. Dig Dis Sci 40: 538