Multi-voxel magnetic resonance spectroscopy at 3 T in patients with idiopathic generalised epilepsy

Seizure

Volumn 19, Issue 8, 2010, Pages 485-492

  Doelken, M T ^a   Mennecke, A ^a   Stadlbauer, A ^a   Kecskemeti L ^a   Kasper, B S ^a   Struffert, T ^a   Doerfler, A ^a   Stefan, H ^a   Hammen, Thilo ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Epilepsy; MRI; MRS; Spectroscopy

Indexed keywords

CHOLINE; GLUTAMIC ACID;

ADULT; ARTICLE; BASAL GANGLION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; GENERALIZED EPILEPSY; GRAY MATTER; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS; IDIOPATHIC DISEASE; INSULA; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARIETAL LOBE; PRIORITY JOURNAL; PUTAMEN; TONIC CLONIC SEIZURE; WHITE MATTER;

ADOLESCENT; ADULT; ASPARTIC ACID; BASAL GANGLIA; BRAIN; CEREBRAL CORTEX; CHOLINE; CREATINE; EPILEPSY, GENERALIZED; EPILEPSY, TONIC-CLONIC; FEMALE; GLUTAMIC ACID; GLUTAMINE; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; INOSITOL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; THALAMUS; YOUNG ADULT;

EID: 77957284766     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seizure.2010.07.005     Document Type: Article

References (44)

1. A. Bernasconi, N. Bernasconi, J. Natsume, S.B. Antel, F. Andermann, and D.L. Arnold Magnetic resonance spectroscopy and imaging of the thalamus in idiopathic generalized epilepsy Brain 126 2003 2447 2454 (Pubitemid 37314434)
2. J.S. Duncan Brain imaging in idiopathic generalized epilepsies Epilepsia 46 Suppl. 9 2005 108 111
3. D. Fojtikova, M. Brazdil, J. Horky, M. Mikl, R. Kuba, and P. Krupa Magnetic resonance spectroscopy of the thalamus in patients with typical absence epilepsy Seizure 15 2006 533 540
4. K. Lin, J.H. Carrete, J. Lin, M.M. Peruchi, G.M. de Araujo Filho, and M.S. Guaranha Magnetic resonance spectroscopy reveals an epileptic network in juvenile myoclonic epilepsy Epilepsia 50 2009 1191 1200
5. I. Savic, Y. Osterman, and G. Helms MRS shows syndrome differentiated metabolite changes in human-generalized epilepsies Neuroimage 21 2004 163 172
6. R.J. Simister, M.A. McLean, G.J. Barker, and J.S. Duncan Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy Neurology 61 2003 897 902
7. F.G. Wormann The value of neuroimaging in diagnosis of epilepsy Ther Umsch 58 2001 645 649
8. M.T. Doelken, G. Richter, H. Stefan, A. Doerfler, A. Noemayr, and T. Kuwert Multimodal coregistration in patients with temporal lobe epilepsy - results of different imaging modalities in lateralization of the affected hemisphere in MR imaging positive and negative subgroups AJNR Am J Neuroradiol 28 2007 449 454
9. M.T. Doelken, H. Stefan, E. Pauli, A. Stadlbauer, T. Struffert, and T. Engelhorn (1)H-MRS profile in MRI positive- versus MRI negative patients with temporal lobe epilepsy Seizure 17 2008 490 497
10. T. Hammen, H. Stefan, K.E. Eberhardt, B.H. Huk, and B.F. Tomandl Clinical applications of 1H-MR spectroscopy in the evaluation of epilepsies - what do pathological spectra stand for with regard to current results and what answers do they give to common clinical questions concerning the treatment of epilepsies? Acta Neurol Scand 108 2003 223 238
11. N. Schuff, F. Ezekiel, A.C. Gamst, D.L. Amend, A.A. Capizzano, and A.A. Maudsley Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging Magn Reson Med 45 2001 899 907
12. A. Ebel, and A.A. Maudsley Detection and correction of frequency instabilities for volumetric 1H echo-planar spectroscopic imaging Magn Reson Med 53 2005 465 469 (Pubitemid 40171061)
13. I. Savic, A. Lekvall, D. Greitz, and G. Helms MR spectroscopy shows reduced frontal lobe concentrations of N-acetyl aspartate in patients with juvenile myoclonic epilepsy Epilepsia 41 2000 290 296
14. S.B. Mory, L.M. Li, C.A. Guerreiro, and F. Cendes Thalamic dysfunction in juvenile myoclonic epilepsy: a proton MRS study Epilepsia 44 2003 1402 1405
15. G. Helms, C. Ciumas, S. Kyaga, and I. Savic Increased thalamus levels of glutamate and glutamine (Glx) in patients with idiopathic generalised epilepsy J Neurol Neurosurg Psychiatr 77 2006 489 494
16. ILAE Commission on classification and terminology of the international league against epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes Epilepsia 30 1989 389 399
17. J. Engel Jr. Report of the ILAE classification core group Epilepsia 47 2006 1558 1568
18. H.J. Huppertz, C. Grimm, S. Fauser, J. Kassubek, I. Mader, and A. Hochmuth Enhanced visualization of blurred grey-white matter junctions in focal cortical dysplasia by voxel-based 3D MRI analysis Epilepsy Res 67 2005 35 50
19. R. Kreis, T. Ernst, and B.D. Ross Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy Magn Reson Med 30 1993 424 437
20. P.J. Pouwels, K. Brockmann, B. Kruse, B. Wilken, M. Wick, and F. Hanefeld Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS Pediatr Res 46 1999 474 485
21. A. Horska, W.E. Kaufmann, L.J. Brant, S. Naidu, J.C. Harris, and P.B. Barker In vivo quantitative proton MRSI study of brain development from childhood to adolescence J Magn Reson Imaging 15 2002 137 143
22. S.W. Provencher Automatic quantitation of localized in vivo 1H spectra with LCModel NMR Biomed 14 2001 260 264
23. E.H. Baker, G. Basso, P.B. Barker, M.A. Smith, D. Bonekamp, and A. Horska Regional apparent metabolite concentrations in young adult brain measured by (1)H MR spectroscopy at 3 Tesla J Magn Reson Imaging 27 2008 489 499
24. W. Zaaraoui, L. Fleysher, R. Fleysher, S. Liu, B.J. Soher, and O. Gonen Human brain-structure resolved T(2) relaxation times of proton metabolites at 3 Tesla Magn Reson Med 57 2007 983 989
25. T. Hammen, A. Stadlbauer, B. Tomandl, O. Ganslandt, E. Pauli, and W. Huk Short TE single-voxel 1H-MR spectroscopy of hippocampal structures in healthy adults at 1. 5 Tesla - how reproducible are the results? NMR Biomed 18 2005 195 201
26. R Development Core Team. A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. R version 2 8 0 2008.
27. H.J. Meencke, and D. Janz Neuropathological findings in primary generalized epilepsy: a study of eight cases Epilepsia 25 1984 8 21
28. P. Gloor Generalized cortico-reticular epilepsies. Some considerations on the pathophysiology of generalized bilaterally synchronous spike and wave discharge Epilepsia 9 1968 249 263
29. H.K. Meeren, J.P. Pijn, E.L. Van Luijtelaar, A.M. Coenen, and F.H. Lopes da Silva Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats J Neurosci 22 2002 1480 1495
30. E. Niedermeyer EEG and the differential diagnosis of common generalized (centrencephalic) epilepsy Electroencephalogr Clin Neurophysiol 26 1969 120
31. M.J. Koepp Juvenile myoclonic epilepsy - a generalized epilepsy syndrome? Acta Neurol Scand Suppl 181 2005 57 62
32. R. Kuzniecky, H. Hetherington, J. Pan, J. Hugg, C. Palmer, and F. Gilliam Proton spectroscopic imaging at 4.1 Tesla in patients with malformations of cortical development and epilepsy Neurology 48 1997 1018 1024
33. T. Suzuki, A.V. gado-Escueta, K. Aguan, M.E. Alonso, J. Shi, and Y. Hara Mutations in EFHC1 cause juvenile myoclonic epilepsy Nat Genet 36 2004 842 849
34. R.J. Simister, M.A. McLean, G.J. Barker, and J.S. Duncan A proton magnetic resonance spectroscopy study of metabolites in the occipital lobes in epilepsy Epilepsia 44 2003 550 558
35. O.A. Petroff, L.D. Errante, D.L. Rothman, J.H. Kim, and D.D. Spencer Glutamate-glutamine cycling in the epileptic human hippocampus Epilepsia 43 2002 703 710
36. O.A. Petroff, L.D. Errante, D.L. Rothman, J.H. Kim, and D.D. Spencer Neuronal and glial metabolite content of the epileptogenic human hippocampus Ann Neurol 52 2002 635 642
37. H. Blumenfeld From molecules to networks: cortical/subcortical interactions in the pathophysiology of idiopathic generalized epilepsy Epilepsia 44 Suppl. 2 2003 7 15
38. S.J. Slaght, T. Paz, S. Mahon, N. Maurice, S. Charpier, and J.M. Deniau Functional organization of the circuits connecting the cerebral cortex and the basal ganglia: implications for the role of the basal ganglia in epilepsy Epileptic Disord 4 Suppl. 3 2002 S9 22
39. S. Dupont, F. Semah, M. Baulac, and Y. Samson The underlying pathophysiology of ictal dystonia in temporal lobe epilepsy: an FDG-PET study Neurology 51 1998 1289 1292
40. T.R. Henry, J.C. Mazziotta, J. Engel Jr., P.D. Christenson, J.X. Zhang, and M.E. Phelps Quantifying interictal metabolic activity in human temporal lobe epilepsy J Cereb Blood Flow Metab 10 1990 748 757
41. M. Dematteis, P. Kahane, L. Vercueil, and A. Depaulis MRI evidence for the involvement of basal ganglia in epileptic seizures: an hypothesis Epileptic Disord 5 2003 161 164
42. C. Deransart, and A. Depaulis The control of seizures by the basal ganglia? A review of experimental data Epileptic Disord 4 Suppl 3 2002 S61 S72
43. Y. Lu, and X. Wang Genes associated with idiopathic epilepsies: a current overview Neurol Res 31 2009 135 143
44. M. Durner, M.A. Keddache, L. Tomasini, S. Shinnar, S.R. Resor, and J. Cohen Genome scan of idiopathic generalized epilepsy: evidence for major susceptibility gene and modifying genes influencing the seizure type Ann Neurol 49 2001 328 335