Downregulation of nucleostemin causes G1 cell cycle arrest via a p53-independent pathway in prostate cancer PC-3 cells

Urologia Internationalis

Volumn 85, Issue 2, 2010, Pages 221-227

  Liu, Ranlu ^a   Zhang, Zhihong ^a   Xu, Yong ^a  

^a SECOND HOSPITAL OF TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

DNA microarray; Nucleostemin; PC 3 cell cycle; Prostate cancer

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; CYCLIN DEPENDENT KINASE INHIBITOR 2C; NUCLEAR PROTEIN; NUCLEOSTEMIN; PROTEIN P53; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA MICROARRAY; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION; GENOME; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; G1 PHASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GTP-BINDING PROTEINS; HUMANS; MALE; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; PROSTATIC NEOPLASMS; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77957284391     PISSN: 00421138     EISSN: None     Source Type: Journal    
DOI: 10.1159/000315968     Document Type: Article

References (24)

1. Tsai RY, McKay RD: A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Genes Dev 2002; 16: 2991-3003. (Pubitemid 35424188)
2. Baddoo M, Hill K, Wilkinson R, Gaupp D, Hughes C, et al: Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection. J Cell Biochem 2003; 89: 1235-1249. (Pubitemid 36959389)
3. Liu SJ, Cai ZW, Liu YJ, Dong MY, Sun LQ, et al: Role of nucleostemin in the growth regulation of gastric cancer, liver cancer and other cancers. World J Gastroenterol 2004; 10: 1246-1249.
4. Beekman C, Nichane M, De Clercq S, Maetens M, Floss T, et al: Evolutionarily conserved role of nucleostemin controlling proliferation of stem/progenitor cells during early vertebrate development. Mol Cell Biol 2006; 26: 9291-9301. (Pubitemid 44904424)
5. Roth JA, Swisher SG, Meyn RE: P53 tumor suppressor gene therapy for cancer. Oncology 1999; 13: 148-154.
6. Downing SR, Russell PJ, Jackson P: Alterations of p53 are common in early stage prostate cancer. Can J Urol 2003; 10: 1924-1933.
7. Liu RL, Zhang ZH, Zhao WM, Wang M, Qi SY, et al: The expression of nucleostemin in prostate cancer and the effects on the proliferation of PC-3 cells after knocking down its expression. Chin Med J 2008; 121: 299-304.
8. Carroll AG, Voeller HJ, Suqars L, Gelmann EP: P53 oncogene mutations in three human prostate cancer cell lines. Prostate 1993; 23: 123-134. (Pubitemid 23289894)
9. Van Bokhoven A, Verella-Garcia M, Korch C, Johannes WU, Smith EE, et al: Molecular characterization of human prostate carcinoma cell lines. Prostate 2003; 57: 205-225. (Pubitemid 37267805)
10. Sijin L, Ziwei C, Yajun L, Meiyu D, Hongwei Z, et al: The effect of knocking-down nucleostemin gene expression on the in vitro proliferation and in vivo tumorigenesis of HeLa cells. J Exp Clin Cancer Res 2004; 23: 529-538. (Pubitemid 39490640)
11. Yang L, Yeh SD, Xie S, Altuwaijri S, Ni J, et al: Androgen suppresses PML protein expression in prostate cancer CWR22R cells. Biochem Biophys Res Commun 2004; 314: 69-75. (Pubitemid 38058370)
12. Zhang L, Zhang Y, Zhou Y, An S, Zhou Y, et al: Response of gene expression in Saccharomyces cerevisiae to amphotericin B and nystatin measured by microarrays. J Antimicrob Chemother 2002; 49: 905-915. (Pubitemid 34692884)
13. Jafarnejad SM, Mowla SJ, Matin MM: Knocking-down the expression of nucleostemin significantly decreases rate of proliferation of rat bone marrow stromal stem cells in an apparently p53-independent manner. Cell Prolif 2008; 41: 28-35.
14. Nikpour P, Mowla SJ, Jafarnejad SM, Fischer U, Schulz WA: Differential effects of nucleostemin suppression on cell cycle arrest and apoptosis in the bladder cancer cell lines 5637 and SW1710. Cell Prolif 2009; 42: 762-769.
15. Dyson N: The regulation of E2F by pRBfamily proteins. Genes Dev 1998; 12: 2245-2262.
16. Drobnjak M, Osman I, Scher HI, Fazzari M, Cordon-Cardo C: Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone. Clin Cancer Res 2000; 6: 1891-1895. (Pubitemid 30305086)
17. Takimoto R, Kato J, Terui T, Takada K, Kuroiwa G, et al: Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor. Cancer Biol Ther 2005; 4: 421-428. (Pubitemid 41351260)
18. Cangul H: Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. BMC Genet 2004; 5: 27-38. (Pubitemid 41363876)
19. Segawa T, Nau ME, Xu LL, Chilukuri RN, Makarem M, et al: Androgen-induced expression of endoplasmic reticulum stress response genes in prostate cancer cells. Oncogene 2002; 21: 8749-8758. (Pubitemid 36132396)
20. Tu LC, Yan X, Hood L, Lin B: Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. Mol Cell Proteomics 2007; 6: 575-588. (Pubitemid 46630091)
21. Goto Y, Hayashi R, Muramatsu T, Ogawa H, Eguchi I, et al: JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. Biochim Biophys Acta 2006; 1759: 60-68. (Pubitemid 44304393)
22. Liu SJ, Zhang ZH, Zhang DQ, Sui XM, Liu YJ, et al: Gene profiling after knockingdown expression of nucleostemin in HeLa cells using oligonucleotide DNA microarray. J Exp Clin Cancer Res 2006; 25: 575-583. (Pubitemid 46166772)
23. Meng L, Lin T, Tsai RY: Nucleoplasmic mobilization of nucleostemin stabilizes MDM2 and promotes G2-M progression and cell survival. J Cell Sci 2008; 121: 4037-4046.
24. Dai MS, Sun XX, Lu H: Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. Mol Cell Biol 2008; 28: 4365-4376. (Pubitemid 351904958)