Monocytes from children with clinically stable cystic fibrosis show enhanced expression of toll-like receptor 4

Pediatric Pulmonology

Volumn 45, Issue 9, 2010, Pages 883-889

  Sturges, Nina C ^a   Wikström, Matthew E ^a   Winfield, Kaye R ^a   Gard, Samantha E ^a   Brennan, Siobhain ^a   Sly, Peter D ^a   Upham, John W ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cystic fibrosis; Cytokines; Monocytes; Pathogens; Toll like receptor

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; CD14 ANTIGEN; CEFALEXIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANTIBIOTIC PROPHYLAXIS; ARTICLE; BLOOD; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; FLOW CYTOMETRY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT INFECTION; RESPIRATORY TRACT INFECTION;

BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CELLS, CULTURED; CHILD, PRESCHOOL; CYSTIC FIBROSIS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNITY, INNATE; INFANT; MALE; MONOCYTES; RESPIRATORY TRACT INFECTIONS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 77957275161     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.21230     Document Type: Article

References (25)

1. Davis PB. Cystic fibrosis since 1938. Am J Respir Crit Care Med 2006;173:475-482.
2. Davis PB, Drumm M, Konstan MW. Cystic fibrosis. Am J Respir Crit Care Med 1996;154:1229-1256.
3. Butchar JP, Parsa KV, Marsh CB, Tridandapani S. Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response. Curr Pharm Des 2006;12:4143-4153. (Pubitemid 44669743)
4. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990;249:1431-1433.
5. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999;11:443-451.
6. Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 2000;97: 13766-13771.
7. Muhlebach MS, Stewart PW, Leigh MW, Noah TL. Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. Am J Respir Crit Care Med 1999;160:186-191.
8. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DW. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995;151:1075-1082.
9. Sly PD, Brennan S, Gangell C, de Klerk N, Murray C, Mott L, Stick SM, Robinson PJ, Robertson CF, Ranganathan SC, on behalf of the Australian Respiratory Early Surveillance Team for Cystic F. Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. Am J Respir Crit Care Med 2009; 180:146-152.
10. Taylor RC, Richmond P, Upham JW. Toll-like receptor 2 ligands inhibit TH2 responses to mite allergen. J Allergy Clin Immunol 2006;117:1148-1154.
11. Pitrez PM, Brennan S, Turner S, Sly PD. Nasal wash as an alternative to bronchoalveolar lavage in detecting early pulmonary inflammation in children with cystic fibrosis. Respirology 2005;10:177-182. (Pubitemid 40638001)
12. Armstrong DS, Grimwood K, Carlin JB, Carzino R, Gutierrez JP, Hull J, et al. Lower airway inflammation in infants and young children with cystic fibrosis. Am J Respir Crit Care Med 1997;156:1197-1204.
13. Kerby GS, Cottin V, Accurso FJ, Hoffmann F, Chan ED, Fadok VA, et al. Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 2002;283:L188-L197.
14. Hubeau C, Puchelle E, Gaillard D. Distinct pattern of immune cell population in the lung of human fetuses with cystic fibrosis. J Allergy Clin Immunol 2001;108:524-529. (Pubitemid 32978021)
15. Grissell TV, Chang AB, Gibson PG. Reduced toll-like receptor 4 and substance P gene expression is associated with airway bacterial colonization in children. Pediatr Pulmonol 2007;42:380-385.
16. Greene CM, Carroll TP, Smith SG, Taggart CC, Devaney J, Griffin S, et al. TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J Immunol 2005;174:1638-1646.
17. Muir A, Soong G, Sokol S, Reddy B, Gomez MI, Van Heeckeren A, et al. Toll-like receptors in normal and cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol 2004;30:777-783.
18. Hauber HP, Tulic MK, Tsicopoulos A, Wallaert B, Olivenstein R, Daigneault P, et al. Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis. Can Respir J 2005;12:13-18.
19. Zaman MM, Gelrud A, Junaidi O, Regan MM, Warny M, Shea JC, et al. Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin Diagn Lab Immunol 2004;11:819-824.
20. Gutierrez JP, Grimwood K, Armstrong DS, Carlin JB, Carzino R, Olinsky A, et al. Interlobar differences in bronchoalveolar lavage fluid from children with cystic fibrosis. Eur Respir J 2001;17:281-286. (Pubitemid 32600589)
21. Davis SD, Fordham LA, Brody AS, Noah TL, Retsch-Bogart GZ, Qaqish BF, et al. Computed tomography reflects lower airway inflammation and tracks changes in early cystic fibrosis. Am J Respir Crit Care Med 2007;175:943-950.
22. Petit-Bertron AF, Tabary O, Corvol H, Jacquot J, Clement A, Cavaillon JM, et al. Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10. Cytokine 2008;41:54-60.
23. Koller B, Kappler M, Latzin P, Gaggar A, Schreiner M, Takyar S, et al. TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease. J Immunol 2008;181:2753-2763.
24. Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 1994;12:141-179.
25. Brennan S, Cooper D, Sly PD. Directed neutrophil migration to IL-8 is increased in cystic fibrosis: a study of the effect of erythromycin. Thorax 2001;56:62-64. (Pubitemid 32041721)