Involvement of the human pedunculopontine nucleus region in voluntary movements

Neurology

Volumn 75, Issue 11, 2010, Pages 950-959

  Tsang, E W ^a,c   Hamani, C ^a,b   Moro, E ^a   Mazzella, F ^a   Poon, Y Y ^a   Lozano, A M ^a,b,c   Chen, R ^a,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b Division of Neurosurgery   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; BROMOCRIPTINE; ENTACAPONE; LEVODOPA; PRAMIPEXOLE; RASAGILINE; ROPINIROLE; SELEGILINE;

ADULT; AGED; ANKLE; ARTICLE; BASAL GANGLION; CLINICAL ARTICLE; DRUG EFFECT; EVOKED RESPONSE; FEMALE; HUMAN; LOCOMOTION; MALE; OSCILLATION; PARKINSON DISEASE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PREFRONTAL CORTEX; PRIORITY JOURNAL; VOLUNTARY MOVEMENT; WRIST; BRAIN DEPTH STIMULATION; CORTICAL SYNCHRONIZATION; ELECTRODE IMPLANT; ELECTROENCEPHALOGRAPHY; EVOKED MUSCLE RESPONSE; MIDDLE AGED; MOTOR CORTEX; MOVEMENT (PHYSIOLOGY); NERVE CELL NETWORK; PATHOPHYSIOLOGY; PHYSIOLOGY; SOMATOSENSORY CORTEX; STATISTICAL ANALYSIS; SUBTHALAMIC NUCLEUS;

AGED; BASAL GANGLIA; CORTICAL SYNCHRONIZATION; DATA INTERPRETATION, STATISTICAL; DEEP BRAIN STIMULATION; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, MOTOR; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; MOVEMENT; NERVE NET; PARKINSON DISEASE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; SOMATOSENSORY CORTEX; SUBTHALAMIC NUCLEUS;

EID: 77957267178     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181f25b35     Document Type: Article

References (40)

1. Pahapill PA, Lozano AM. The pedunculopontine nucleus and Parkinson's disease. Brain 2000;123:1767-1783.
2. Garcia-Rill E. The pedunculopontine nucleus. Prog Neu-robiol 1991;36:363-389.
3. Winn P. How best to consider the structure and function of the pedunculopontine tegmental nucleus: evidence from animal studies. J Neurol Sci 2006;248:234-250.
4. Aravamuthan BR, Muthusamy KA, Stein JF, Aziz TZ, Johansen-Berg H. Topography of cortical and subcortical connections of the human pedunculopontine and subtha-lamic nuclei. Neuroimage 2007;37:694-705.
5. (15)O] H2O PET study. Hum Brain Mapp 2009;30: 3901-3909.
6. Matsumura M, Watanabe K, Ohye C. Single-unit activity in the primate nucleus tegmenti pedunculopontinus related to voluntary arm movement. Neurosci Res 1997;28:155-165.
7. Weinberger M, Hamani C, Hutchison WD, Moro E, Lozano AM, Dostrovsky JO. Pedunculopontine nucleus microelectrode recordings in movement disorder patients. Exp Brain Res 2008;188:165-174.
8. Garcia-Rill E, Skinner RD. The mesencephalic locomotor region, I: activation of a medullary projection site. Brain Res 1987;411:1-12.
9. Kinjo N, Atsuta Y, Webber M, Kyle R, Skinner RD, Garcia-Rill E. Medioventral medulla-induced locomotion. Brain Res Bull 1990;24:509-516.
10. Eidelberg E, Walden JG, Nguyen LH. Locomotor control in macaque monkeys. Brain 1981;104:647-663.
11. Conde H, Dormont JF, Farin D. The role of the peduncu-lopontine tegmental nucleus in relation to conditioned motor performance in the cat, II: effects of reversible inac-tivation by intracerebral microinjections. Exp Brain Res 1998;121:411-418.
12. Garcia-Rill E, Skinner RD, Fitzgerald JA. Chemical activation of the mesencephalic locomotor region. Brain Res 1985;330:43-54.
13. Mazzone P, Lozano A, Stanzione P, et al. Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease. Neuroreport 2005;16:1877-1881.
14. Stefani A, Lozano AM, Peppe A, et al. Bilateral deep brain stimulation of the pedunculopontine and subtha-lamic nuclei in severe Parkinson's disease. Brain 2007; 130:1596-1607.
15. Moro E, Hamani C, Poon YY, et al. Unilateral pedunculo-pontine stimulation improves falls in Parkinson's disease. Brain 2010;133:215-224.
16. Pereira EA, Muthusamy KA, De Pennington N, Joint CA, Aziz TZ. Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease: preliminary experience at Oxford. Br J Neurosurg 2008;22:S41-S44.
17. Hamani C, Moro E, Zadikoff C, Poon YY, Lozano AM. Location of active contacts in patients with primary dysto-nia treated with globus pallidus deep brain stimulation. Neurosurgery 2008;62:217-223.
18. Pollo C, Villemure JG, Vingerhoets F, Ghika J, Maeder P, Meuli R. Magnetic resonance artifact induced by the electrode Activa 3389: an in vitro and in vivo study. Acta Neu-rochir 2004;146:161-164.
19. Paxinos G, Huang X. Atlas of the Human Brainstem. San Diego, CA: Academic Press; 1995.
20. Barrett G, Shibasaki H, Neshige R. Cortical potentials preceding voluntary movement: evidence for three periods of preparation in man. Electroencephalogr Clin Neuro-physiol 1986;63:327-339.
21. Paradiso G, Saint-Cyr JA, Lozano AM, Lang AE, Chen R. Involvement of the human subthalamic nucleus in movement preparation. Neurology 2003;61:1538-1545.
22. Paradiso G, Cunic D, Saint-Cyr JA, et al. Involvement of human thalamus in the preparation of self-paced movement. Brain 2004;127:2717-2731. (Pubitemid 39627380)
23. Rektor I. Scalp-recorded Bereitschaftspotential is the result of the activity of cortical and subcortical generators: a hypothesis. Clin Neurophysiol 2002;113:1998-2005.
24. Fogelson N, Williams D, Tijssen M, van Bruggen G, Speelman H, Brown P. Different functional loops between cerebral cortex and the subthalmic area in Parkinson's disease. Cereb Cortex 2006;16:64-75.
25. Sharott A, Grosse P, Kuhn AA, et al. Is the synchronization between pallidal and muscle activity in primary dysto-nia due to peripheral afferance or a motor drive? Brain 2008;131:473-484.
26. Jenkins IH, Fernandez W, Playford ED, et al. Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomor-phine. Ann Neurol 1992;32:749-757.
27. Rascol O, Sabatini U, Chollet F, et al. Supplementary and primary sensory motor area activity in Parkinson's disease: regional cerebral blood flow changes during finger movements and effects of apomorphine. Arch Neurol 1992;49: 144-148.
28. Marsden JF, Ashby P, Limousin-Dowsey P, Rothwell JC, Brown P. Coherence between cerebellar thalamus, cortex and muscle in man: cerebellar thalamus interactions. Brain 2000;123:1459-1470.
29. Nicolelis MA, Baccala LA, Lin RC, Chapin JK. Sensori-motor encoding by synchronous neural ensemble activity at multiple levels of the somatosensory system. Science 1995;268:1353-1358.
30. Levy R, Ashby P, Hutchison WD, Lang AE, Lozano AM, Dostrovsky JO. Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease. Brain 2002;125:1196-1209.
31. Fogelson N, Williams D, Tijssen M, van Bruggen G, Speelman H, Brown P. Different functional loops between cerebral cortex and the subthalmic area in Parkinson's disease. Cereb Cortex 2006;16:64-75.
32. Brown P, Oliviero A, Mazzone P, Insola A, Tonali P, Di Lazzaro V. Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease. J Neurosci 2001;21:1033-1038.
33. Weinberger M, Mahant N, Hutchison WD, et al. Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease. J Neurophysiol 2006;96:3248-3256.
34. Fogelson N, Williams D, Tijssen M, van Bruggen G, Speelman H, Brown P. Different functional loops between cerebral cortex and the subthalmic area in Parkinson's disease. Cereb Cortex 2006;16:64-75.
35. Brown P. Abnormal oscillatory synchronisation in the motor system leads to impaired movement. Curr Opin Neu-robiol 2007;17:656-664.
36. Androulidakis AG, Kuhn AA, Chen CC, et al. Dopami-nergic therapy promotes lateralized motor activity in the subthalamic area in Parkinson's disease. Brain 2007;130: 457-468.
37. Brucke C, Kempf F, Kupsch A, et al. Movement-related synchronization of gamma activity is lateralized in patients with dystonia. Eur J Neurosci 2008;27:2322-2329.
38. Pierantozzi M, Palmieri MG, Galati S, et al. Pedunculo-pontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients. J Neural Transm 2008;115:731-735.
39. Cassidy M, Mazzone P, Oliviero A, et al. Movement-related changes in synchronization in the human basal ganglia. Brain 2002;125:1235-1246.
40. Kuhn AA, Doyle L, Pogosyan A, et al. Modulation of beta oscillations in the subthalamic area during motor imagery in Parkinson's disease. Brain 2006;129:695-706.