Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients

Journal of Neural Transmission

Volumn 115, Issue 5, 2008, Pages 731-735

  Pierantozzi, Mariangela ^a,b   Palmieri, Maria Giuseppina ^a,b   Galati, Salvatore ^a,b   Stanzione, Paolo ^a,b   Peppe, Antonella ^b   Tropepi, Domenicantonio ^a,b   Brusa, Livia ^a   Pisani, Antonio ^a   Moschella, Vincenzo ^a   Marciani, Maria Grazia ^a,b   Mazzone, Paolo ^c   Stefani, Alessandro ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c CTO Hospital ASL Roma C   (Italy)

Author keywords

Deep brain stimulation; Hoffman Roflex; Pedunculopontine nucleus; Spinal cord excitability

Indexed keywords

ADULT; ARTICLE; BASAL GANGLION; BRAIN DEPTH STIMULATION; BRAIN STEM RESPONSE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; HOFFMANN REFLEX; HUMAN; PARKINSON DISEASE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PRIORITY JOURNAL; SPINAL REFLEX;

AGED; CASE-CONTROL STUDIES; DEEP BRAIN STIMULATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; H-REFLEX; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; SPINAL CORD;

EID: 44749090395     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-007-0001-8     Document Type: Article

References (20)

1. Delwaide PJ (2001) Parkinsonian rigidity. Funct Neurol 16:147-156
2. Delwaide PJ, Pepin JL, Maertens de Noordhout A (1991) Short-latency autogenic inhibition in patients with parkinsonian rigidity. Ann Neurol 30:83-89
3. Delwaide PJ, Pepin JL, Maertens de Noordhout A (1993) The audiospinal reaction in Parkinsonian patients reflect functional changes in reticular nuclei. Ann Neurol 33:63-69
4. Delwaide PJ, Pepin JL, De Pasqua V, Maertens de Noordhout A (2000) Projections from basal ganglia to tegmentum: a subcortical route for explaining the pathophysiology of Parkinson's disease signs? J Neurol 247(suppl 2):II/75-II/81
5. Florio T, Scarnati E, Gonfalone G, Minchella D, Galati S, Stanzione P, Stefani A, Mazzone P (2007) High-frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat. Eur J Neurosci 25:1174-1186
6. Galati S, Mazzone P, Fedele E, Pisani A, Peppe A, Pierantozzi M, Brusa L, Tropepi D, Moschella V, Reiteri M, Stanzione P, Bernardi G, Stefani A (2006) Biochemical and electrophysiological nigral changes driven by subthalamic stimulation in Parkinson's disease patients. Eur J Neurosci 23:2923-2928
7. Kushnir M, Klein C, Rabey JM (2000) H reflex behavior in Parkinson's disease patients. Effect of stimulus duration. Parkinsonism Relat Disord 5:243-246
8. Kushnir M, Klein C, Rabey JM (2001) H reflex behavior in Parkinson's disease patients and patients with extra-pyramidal and pyramidal signs combined. J Neurol Sci 186:101-105
9. Kushnir M, Klein C, Pollak L, Rabey JM (2002) H reflex threshold in Parkinson's disease patients for different stimulus duration. Parkinsonism Relat Disord 9:85-87
10. Mazzone P, Lozano A, Stanzione P, Galati S, Peppe A, Scarnati E, Peppe A, Stefani A (2005) Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease. Neuroreport 16:1879:1883
11. Mena-Segovia J, Bolam JP, Magill PJ (2004) Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family? Trends Neurosci 27:585-588
12. Meunier S, Pol S, Houeto JL, Vidailhet M (2000) Abnormal reciprocal inhibiton between antagonist muscles in Parkinson's disease. Brain 123:1017-1026
13. Munro-Davies LE, Winter J, Aziz TZ, Stein JF (1999) The role of the pedunculopontine region in basal-ganglia mechanisms of akinesia. Exp Brain Res 129:511-7
14. Pahapill A, Lozano AM (2000) The Pedunculopontine nucleus and Parkinson's disease. Brain 123:1767-1783
15. Plaha P, Gill SS (2005) Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease. Neuroreport 16:1883-1887
16. Potter M, Illert M, Wenzelburger R, Deuschl G, Volkmann J (2004) The effect of subthalamic nucleus stimulation on autogenic inhibition in Parkinson disease. Neurology 63:1234-1239
17. Preston DC, Shapiro BE (2005) Fundamental of nerve conduction studies: late responses. In: Preston DC, Shapiro BE (eds) Electromyography and neuromuscular disorders. Clinical-electrophysiologic correlations, 2nd edn. Elsevier, Philadelphia, pp 53-56
18. Stefani A, Lozano A, Peppe A, Stanzione P, Galati S, Tropepi D, Pierantozzi M, Brusa L, Scarnati E, Mazzone P (2007) Bilateral deep-brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain 130:1596-1607
19. Takakusaki K, Habaguchi T, Ohtinata-Sugimoto J, Saitoh K, Sakamoto T (2003) Basal ganglia efferents to the brainstem centres controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction. Neuroscience 119:293-308
20. Tisch S, Rothwell JC, Di Lazzaro V, Di leone M, CApone F, Proficue P, Insola A, MAzzone P (2007) The physiological effects of pedunculopontine stimulation in patients with Parkinson's disease. In: Abstracts of the eleventh international congress of Parkinson's disease and movement disorders, Istanbul, Turkey, 3-7 June 2007