Twenty-nine Leydig cell tumors: Histological features, outcomes and implications for management

International Journal of Urology

Volumn 17, Issue 10, 2010, Pages 886-889

  Heer, Rakesh ^a   Jackson, Matthew J ^a   El Sherif, Amira ^b   Thomas, David J ^a  

^a FREEMAN HOSPITAL   (United Kingdom)

^b ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

germ cell and embryonal; Leydig cell tumor; neoplasms; testicular; testis; testis sparing surgery

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RISK; CANCER SURGERY; CLINICAL ARTICLE; DISEASE COURSE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LEYDIG CELL TUMOR; MALE; MALIGNANT TRANSFORMATION; MITOSIS; NECROSIS; ORCHIECTOMY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TUMOR VOLUME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; HUMANS; LEYDIG CELL TUMOR; MALE; MIDDLE AGED; ORCHIECTOMY; TESTICULAR NEOPLASMS; TREATMENT OUTCOME; UROLOGIC SURGICAL PROCEDURES, MALE; YOUNG ADULT;

EID: 77957264088     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2010.02616.x     Document Type: Article

References (29)

1. Carmignani L, Colombo R, Gadda F et al. Conservative surgical therapy for leydig cell tumor. J. Urol. 2007 178 : 507 11 discussion 511. (Pubitemid 46984587)
2. Carmignani L, Gadda F, Gazzano G et al. High incidence of benign testicular neoplasms diagnosed by ultrasound. J. Urol. 2003 170 : 1783 6. (Pubitemid 37254928)
3. Farkas LM, Szekely JG, Pusztai C, Baki M. High frequency of metastatic Leydig cell testicular tumours. Oncology 2000 59 : 118 21.
4. Carmignani L, Salvioni R, Gadda F et al. Long-term followup and clinical characteristics of testicular Leydig cell tumor: experience with 24 cases. J. Urol. 2006 176 : 2040 3 discussion 2043. (Pubitemid 44633179)
5. Giannarini G, Mogorovich A, Menchini Fabris F et al. Long-term followup after elective testis sparing surgery for Leydig cell tumors: a single center experience. J. Urol. 2007 178 : 872 6 quiz 1129. (Pubitemid 47211104)
6. Kim I, Young RH, Scully RE. Leydig cell tumors of the testis. A clinicopathological analysis of 40 cases and review of the literature. Am. J. Surg. Pathol. 1985 9 : 177 92. (Pubitemid 15045913)
7. Glavind K, Sondergaard G. Leydig cell tumour: diagnosis and treatment. Case report and review. Scand. J. Urol. Nephrol. 1988 22 : 343 5. (Pubitemid 19001969)
8. Mosharafa AA, Foster RS, Bihrle R et al. Does retroperitoneal lymph node dissection have a curative role for patients with sex cord-stromal testicular tumors? Cancer 2003 98 : 753 7. (Pubitemid 36959271)
9. Cheville JC, Sebo TJ, Lager DJ, Bostwick DG, Farrow GM. Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. Am. J. Surg. Pathol. 1998 22 : 1361 7.
10. Colpi GM, Carmignani L, Nerva F, Guido P, Gadda F, Castiglioni F. Testicular-sparing microsurgery for suspected testicular masses. BJU Int. 2005 96 : 67 9. (Pubitemid 40942871)
11. Giannarini G, Dieckmann KP, Albers P, Heidenreich A, Pizzocaro G. Organ-Sparing Surgery for Adult Testicular Tumours: a systematic review of the literature. Eur. Urol. 2010 57 : 780 90.
12. Suardi N, Strada E, Colombo R et al. Leydig cell tumour of the testis: presentation, therapy, long-term follow-up and the role of organ-sparing surgery in a single-institution experience. BJU Int. 2009 103 : 197 200.
13. Conkey DS, Howard GC, Grigor KM, McLaren DB, Kerr GR. Testicular sex cord-stromal tumours: the Edinburgh experience 1988-2002, and a review of the literature. Clin. Oncol. (R. Coll. Radiol.) 2005 17 : 322 7.
14. Bertram KA, Bratloff B, Hodges GF, Davidson H. Treatment of malignant Leydig cell tumor. Cancer 1991 68 : 2324 9.
15. Di Tonno F, Tavolini IM, Belmonte P et al. Lessons from 52 patients with leydig cell tumor of the testis: the GUONE (North-Eastern Uro-Oncological Group, Italy) experience. Urol. Int. 2009 82 : 152 7.
16. Davis JM, Woodroof J, Sadasivan R, Stephens R. Case report: congenital adrenal hyperplasia and malignant Leydig cell tumor. Am. J. Med. Sci. 1995 309 : 63 5.
17. O'Donovan JJ, Terry TR, Williams G. Occult Leydig cell testicular tumour presenting with gynaecomastia. J. R. Soc. Med. 1989 82 : 49 50. (Pubitemid 19040056)
18. Dogra VS, Gottlieb RH, Rubens DJ, Liao L. Benign intratesticular cystic lesions: US features. Radiographics 2001 21 (Spec No S273 81. (Pubitemid 33706972)
19. Fernandez GC, Tardaguila F, Rivas C et al. Case report: MRI in the diagnosis of testicular Leydig cell tumour. Br. J. Radiol. 2004 77 : 521 4. (Pubitemid 38807571)
20. Loeser A, Vergho DC, Katzenberger T et al. Testis-sparing surgery versus radical orchiectomy in patients with Leydig cell tumors. Urology 2009 74 : 370 2.
21. Huddart RA, Norman A, Moynihan C et al. Fertility, gonadal and sexual function in survivors of testicular cancer. Br. J. Cancer 2005 93 : 200 7. (Pubitemid 41133206)
22. Tokuc R, Sakr W, Pontes JE, Haas GP. Accuracy of frozen section examination of testicular tumors. Urology 1992 40 : 512 16. (Pubitemid 23003196)
23. Connolly SS, D'Arcy FT, Bredin HC, Callaghan J, Corcoran MO. Value of frozen section analysis with suspected testicular malignancy. Urology 2006 67 : 162 5. (Pubitemid 43069277)
24. Leroy X, Rigot JM, Aubert S, Ballereau C, Gosselin B. Value of frozen section examination for the management of nonpalpable incidental testicular tumors. Eur. Urol. 2003 44 : 458 60. (Pubitemid 37185672)
25. Kommoss F, Oliva E, Bittinger F et al. Inhibin-alpha CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome. Hum. Pathol. 2000 31 : 1055 61.
26. Iczkowski KA, Bostwick DG, Roche PC, Cheville JC. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod. Pathol. 1998 11 : 774 9.
27. Amselgruber WM, Sinowatz F, Erhard M. Differential distribution of immunoreactive S-100 protein in mammalian testis. Histochemistry 1994 102 : 241 5. (Pubitemid 2140226)
28. McLaren K, Thomson D. Localization of S-100 protein in a Leydig and Sertoli cell tumour of testis. Hepatology 1989 15 : 649 52. (Pubitemid 20022918)
29. Sasano H, Nakashima N, Matsuzaki O et al. Testicular sex cord-stromal lesions: immunohistochemical analysis of cytokeratin, vimentin and steroidogenic enzymes. Virchows Arch. A Pathol. Anat. Histopathol. 1992 421 : 163 9.