Lessons from 52 patients with leydig cell tumor of the testis: The GUONE (North-Eastern Uro-Oncological Group, Italy) experience

Urologia Internationalis

Volumn 82, Issue 2, 2009, Pages 152-157

  Di Tonno, Fulvio ^a,k   Tavolini, Ivan Matteo ^e,f   Belmonte, Piero ^c   Bertoldin, Roberto ^d   Cossaro, Enrico ^b   Curti, Paolo ^g   D'Incà, Giulio ^h   Fandella, Andrea ⁱ   Guaitoli, Paolo ^j   Guazzieri, Stefano ^h   Mazzariol, Chiara ^a  

^a Angel's Hospital of Mestre   (Italy)

^b Hospital of Dolo   (Italy)

^c Hospital of Portogruaro   (Italy)

^d Hospital of Camposampiero   (Italy)

^e Venice Hospital   (Italy)

^f UNIVERSITY OF PADOVA   (Italy)

^g UNIVERSITY OF VERONA   (Italy)

^h Hospital of Belluno   (Italy)

ⁱ Treviso Hospital   (Italy)

^j Ospedale Civile di Gorizia   (Italy)

^k 'Veneziana' 'Umberto i' Mestre Civil Hospital   (Italy)

more..

Author keywords

Leydig cell tumor; Orchiectomy; Pathology; Prognostic factors; Retroperitoneal lymph node dissection; Tumor enucleation

Indexed keywords

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CANCER STAGING; ENUCLEATION; FOLLOW UP; HUMAN; LEYDIG CELL TUMOR; LYMPH NODE DISSECTION; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; METASTASIS; MORTALITY; ORCHIECTOMY; PATHOLOGY; PREDICTION AND FORECASTING; PRIORITY JOURNAL; PROGNOSIS; RELAPSE; RISK FACTOR; SERTOLI CELL TUMOR; TESTIS TUMOR;

ADOLESCENT; ADULT; AGE FACTORS; AGED; HUMANS; ITALY; LEYDIG CELL TUMOR; LYMPH NODE EXCISION; MALE; MIDDLE AGED; NEOPLASM METASTASIS; ORCHIECTOMY; PATIENT SELECTION; RETROSPECTIVE STUDIES; TESTICULAR NEOPLASMS; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 63449130975     PISSN: 00421138     EISSN: None     Source Type: Journal    
DOI: 10.1159/000200790     Document Type: Article

References (29)

1. Mostofi FK, Price EB: Tumors of the male genital system; in Atlas of Tumor Pathology, series 2, fascicle 8. Washington DC, Armed Forces Institute of Pathology, 1977, pp 86-99.
2. Cheville JC, Sebo TJ, Lager DJ, Bostwick DG, Farrow G: Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. Am J Surg Pathol 1998; 22: 1361-1367.
3. Grem JL, Robins HI, Wilson KS, Gilchrist K, Trump DL: Metastatic Leydig cell tumor of the testis: report of three cases and review of the literature. Cancer 1986; 58: 2116-2119.
4. Davis S, Di Martino NA, Schneider G: Malignant interstitial cell carcinoma of the testis: report of two cases with steroid synthetic profiles, response to therapy, and review of the literature. Cancer 1981; 47: 425-431.
5. Boden G, Gibb R: Radiotherapy and testicular neoplasms. Lancet 1951; 2: 1195-1197. 6 Mosharafa AA, Foster RS, Bihrle R, Koch MO, Ulbright TM, Einhorn LH, Donohue JP: Does retroperitoneal Lymph node dissection have a curative role for patients with sex cord-stromal testicular tumors? Cancer 2003; 98: 753-757.
6. Naughton CK, Nadler RB, Basler JW, Humphrey PA: Leydig cell hyperplasia. Br J Urol 1998; 81: 282-289. 8 Ghazi AA, Hadayegh F, Khakpour G, Azizi F, Melby JC: Bilateral testicular enlargement due to adrenal remnant in a patient with C11 hydroxilase deficiency congenital adrenal hyperplasia. J Endocrinol Invest 2003; 26: 84-87.
7. McCluggage WG, Shanks JH, Arthur K, Banerjee S: Cellular proliferation and nuclear ploidy assessments augment established prognostic factors in predicting malignancy in testicular Leydig cell tumours. Histopathology 1998; 33: 361-368.
8. Schwarzman MI, Russo P, Bosl GJ, Whitmore WF Jr: Hormone-secreting metastatic interstitial cell tumor of the testis. J Urol 1989; 141: 620-622.
9. Kim I, Young RH, Scully RE: Leydig cell tumors of the testis: a clinicopathologic study of 40 cases and review of the literature. Am J Surg Pathol 1985; 9: 177-192.
10. Dounis A, Papacharalampous A: Clinically occult Leydig cell tumor in a cryptorchid man: report of a case presenting with unilateral gynecomastia and impotence. Eur Urol 1997; 32: 368-370.
11. Maeda T, Itoh N, Kobayashi K, Takahashi A, Masumori N, Tsukamoto T: Elevated serum esradiol suggesting recurrence of Leydig cell tumor nine years after radical orchiectomy. Int J Urol 2003; 9: 659-661.
12. Tavolini IM, Rossato M, Milani C, Dal Moro F: Estradiol plasma levels elevation during follow-up for testicular Leydig-cell tumor is not an unfailing sign of recurrence. Arch Ital Urol Androl 2007; 79: 141-142.
13. Thomas JC, Ross JH, Kay R: Stromal testis tumors in children: a report from the prepubertal testis tumor registry. J Urol 2001; 166: 2338-2340.
14. Dilworth JP, Farrow JM, Osterling JE: Nongerm cell tumors of testis. Urology 1991; 37: 399-417.
15. Carmignani L, Salvioni R, Gadda F, Colecchia M, Gazzano G, Torelli T, Rocco F, Colpi GM, Pizzocaro G: Long-term follow-up and clinical characteristics of testicular Leydig cell tumors: experience with 24 cases. J Urol 2006; 176: 2040-2043.
16. Wegner HE, Herbst H, Andresen R, Dieckmann KP: Leydig cell tumor recurrence after enucleation. J Urol 1996; 156: 1443-1444. Leydig Cell Tumor of the Testis Urol Int 2009;82:152-157 157 19 Giannarini G, Mogorovich A, Menchini Fabris F, Morelli G, De Maria M, Manassero F, Loggini B, Pingitore R, Cavazzana A, Selli C: Long-term follow-up after elective testis sparing surgery for Leydig cell tumors: a single center experience. J Urol 2007; 178: 872-876.
17. Carmignani L, Colombo R, Gadda F, Galasso G, Lania A, Palou J, Algaba F, Villavicencio H, Colpi GM, Decobelli O, Salvioni R, Pizzocaro G, Rigatti P, Rocco F: Conservative surgical therapy for Leydig cell tumor. J Urol 2007; 178: 507-511.
18. Henderson CG, Ahmed AA, Sesterhenn I, Belman AB, Rushton HG: Enucleation for prepubertal Leydig cell tumor. J Urol 2006; 176: 703-705.
19. Ciftci AO, Bingol-Kologlu M, Senocak ME, Tanyel FC, Buyukpamucku M, Buyukpamukcu N: Testicular tumors in children. J Pediatric Surg 2001; 36: 1796-1801.
20. Mottet N, Petit M: Conservative surgery for testicular tumours. Prog Urol 2004; 14: 15-18.
21. D'Elia G, Franzaring L, Black P, Thueroff JW: Late recurrence of Leydig- and Sertoli cell tumor of the testis: the case for primary retroperitoneal lymph node dissection? J Urol 1999; 161(suppl 4):182.
22. Glavind K, Sondergaard G: Leydig cell tumour: diagnosis and treatment. Case report and review. Scand J Urol Nephrol 1988; 22: 343-345.
23. Palazzo JP, Petersen RO, Young RH, Scully RE: Deoxyribonucleic acid flow cytometry of testicular Leydig cell tumors. J Urol 1994; 152: 415-417.
24. Hekimgil M, Altay B, Yakut BD, Soydan S, Ozyurt C, Killi R: Leydig cell tumor of the testis: comparison of histopathological and immunohistochemical features of three azoospermic cases and one malignant case. Pathol Int 2001; 51: 792-796.
25. Donohue JP, Thornhill JA, Foster RS, Rowland RG, Bihrle R: Retroperitoneal lymphadenectomy for clinical stage A testis cancer (1965 to 1989): modifications of technique and impact on ejaculation. J Urol 1993; 149: 237-243.
26. Heidenreich A: Clinical stage I nonseminomatous testicular germ-cell tumors: surgery or watchful waiting, still an issue? Curr Opin Urol 2002; 12: 427-430.
27. Van der Hem KG, Boven E, van Hennik MB, Pinedo HM: Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl- dichloroethane. J Urol 1992; 148: 1256-1259.
28. Jorion JL, de Cooman SE, Dardenne AN, Gosseye S, Wese FX, Van Cangh PJ: Leydig cell tumor of the testis. Acta Urol Belg 1986; 54: 450-458.
29. Gulbahce HE, Lindeland AT, Engel W, Lillemoe TJ: Metastatic Leydig cell tumor with sarcomatoid differentiation. Arch Pathol Lab Med 1999; 123: 1104-1107.