Antipsychotic drug-induced increases in ventral tegmental area dopamine neuron population activity via activation of the nucleus accumbens-ventral pallidum pathway

International Journal of Neuropsychopharmacology

Volumn 13, Issue 7, 2010, Pages 845-860

  Valenti, Ornella ^a   Grace, Anthony A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Antipsychotic; autoreceptor; dopamine; nucleus accumbens; schizophrenia; ventral tegmental area

Indexed keywords

APOMORPHINE; BICUCULLINE; DOPAMINE 2 RECEPTOR; DOPAMINE AUTORECEPTOR; HALOPERIDOL; SERTINDOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL POPULATION; CELL STIMULATION; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; FEEDBACK SYSTEM; GLOBUS PALLIDUS; MALE; NERVE CONDUCTION; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEUS ACCUMBENS; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM;

ANIMALS; ANTIPSYCHOTIC AGENTS; APOMORPHINE; DOPAMINE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DRUG INTERACTIONS; ELECTROPHYSIOLOGICAL PHENOMENA; IMIDAZOLES; INDOLES; MALE; NEURAL PATHWAYS; NEURONS; NUCLEUS ACCUMBENS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE; RECEPTORS, MITOGEN; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; VENTRAL TEGMENTAL AREA;

EID: 77957245363     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145709990599     Document Type: Article

References (52)

1. Abi-Dargham A (2004). Do we still believe in the dopamine hypothesis? New data bring new evidence. International Journal of Neuropsychopharmacology 7 (Suppl. 1), S1-S5. (Pubitemid 38436990)
2. Agid O, Kapur S, Warrington L, Loebel A, Siu C (2008). Early onset of antipsychotic response in the treatment of acutely agitated patients with psychotic disorders. Schizophrenia Research 102, 241-248.
3. Arnt J (1995). Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine. European Journal of Pharmacology 283, 55-62.
4. Arnt J, Skarsfeldt T (1998). Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology 18, 63-101. (Pubitemid 28026679)
5. Belujon P, Grace AA (2008). Critical role of the prefrontal cortex in the regulation of hippocampus-accumbens information flow. Journal of Neuroscience 28, 9797-9805.
6. Boye SM, Rompre PP (2000). Behavioral evidence of depolarization block of dopamine neurons after chronic treatment with haloperidol and clozapine. Journal of Neuroscience 20, 1229-1239.
7. Breier A, Meehan K, Birkett M, David S, et al. (2002). A double-blind, placebo-controlled dose-response comparison of intramuscular olanzapine and haloperidol in the treatment of acute agitation in schizophrenia. Archives of General Psychiatry 59, 441-448. (Pubitemid 34477680)
8. Bunney BS (1988). Effects of acute and chronic neuroleptic treatment on the activity of midbrain dopamine neurons. Annals of the New York Academy of Sciences 537, 77-85.
9. Bunney BS, Chiodo LA, Grace AA (1991). Midbrain dopamine system electrophysiological functioning: a review and new hypothesis. Synapse 9, 79-94.
10. Bunney BS, Grace AA (1978). Acute and chronic haloperidol treatment: comparison of effects on nigral dopaminergic cell activity. Life Sciences 23, 1715-1727.
11. Bunney BS, Walters JR, Roth RH, Aghajanian GK (1973). Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. Journal of Pharmacology and Experimental Therapeutics 185, 560-571.
12. Carlsson A, Lindqvist M (1963). Effect of chlorpromazine or haloperidol on formation of 3methoxytyramine and normetanephrine in mouse brain. Acta Pharmacologica et Toxicologica 20, 140-144.
13. Chiodo LA, Bunney BS (1983). Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. Journal of Neuroscience 3, 1607-1619.
14. Deutch AY (1994). Identification of the neural systems subserving the actions of clozapine: clues from immediateearly gene expression. Journal of Clinical Psychiatry 55 (Suppl. B), 37-42.
15. Fink-Jensen A, Kristensen P (1994). Effects of typical and atypical neuroleptics on Fos protein expression in the rat forebrain. Neuroscience Letters 182, 115-118. (Pubitemid 24362036)
16. Floresco SB, Grace AA (2003). Gating of hippocampalevoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area. Journal of Neuroscience 23, 3930-3943.
17. Floresco SB, Todd CL, Grace AA (2001). Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons. Journal of Neuroscience 21, 4915-4922.
18. Goto Y, Grace AA (2005). Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization. Neuron 47, 255-266. (Pubitemid 41019256)
19. Grace AA, Bunney BS (1983). Intracellular and extracellular electrophysiology of nigral dopaminergic neurons - 1. Identification and characterization. Neuroscience 10, 301-315.
20. Grace AA, Bunney BS (1986). Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. Journal of Pharmacology and Experimental Therapeutics 238, 1092-1100.
21. Grace AA, Bunney BS, Moore H, Todd CL (1997). Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. Trends in Neurosciences 20, 31-37. (Pubitemid 26421230)
22. Grace AA, Floresco SB, Goto Y, Lodge DJ (2007). Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends in Neurosciences 30, 220-227. (Pubitemid 46654234)
23. Hertel P (2006). Comparing sertindole to other new generation antipsychotics on preferential dopamine output in limbic versus striatal projection regions: mechanism of action. Synapse 60, 543-552. (Pubitemid 44537087)
24. Hetey L, Drescher K (1986). Influence of antipsychotics on presynaptic receptors modulating the release of dopamine in synaptosomes of the nucleus accumbens of rats. Neuropharmacology 25, 1103-1109. (Pubitemid 16010224)
25. Hu XT, Dong Y, Zhang XF, White FJ (2005). Dopamine D2 receptor-activated Ca2+ signaling modulates voltagesensitive sodium currents in rat nucleus accumbens neurons. Journal of Neurophysiology 93, 1406-1417. (Pubitemid 40283729)
26. Hu XT, White FJ (1997). Dopamine enhances glutamateinduced excitation of rat striatal neurons by cooperative activation of D1 and D2 class receptors. Neuroscience Letters 224, 61-65.
27. Kane JM, Tamminga CA (1997). Sertindole (Serdolect): preclinical and clinical findings of a new atypical antipsychotic. Expert Opinion on Investigational Drugs 6, 1729-1741. (Pubitemid 27488037)
28. Kapur S, Arenovich T, Agid O, Zipursky R, et al. (2005). Evidence for onset of antipsychotic effects within the first 24 hours of treatment. American Journal of Psychiatry 162, 939-946. (Pubitemid 40676207)
29. Kapur S, Remington G (2001). Dopamine D(2) receptors and their role in atypical antipsychotic action: still necessary and may even be sufficient. Biological Psychiatry 50, 873-883. (Pubitemid 34020700)
30. Kinon BJ, Lieberman JA (1996). Mechanisms of action of atypical antipsychotic drugs: a critical analysis. Psychopharmacology 124, 2-34.
31. Lodge DJ, Grace AA (2007). Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia. Journal of Neuroscience 27, 11424-11430.
32. Lodge DJ, Grace AA (2008). Amphetamine activation of hippocampal drive of mesolimbic dopamine neurons: a mechanism of behavioral sensitization. Journal of Neuroscience 28, 7876-7882.
33. Marcus MM, Nomikos GG, Svensson TH (1996). Differential actions of typical and atypical antipsychotic drugs on dopamine release in the core and shell of the nucleus accumbens. European Neuropsychopharmacology 6, 29-38.
34. Meltzer HY (1980). Relevance of dopamine autoreceptors for psychiatry: preclinical and clinical studies. Schizophrenia Bulletin 6, 456-475.
35. Meltzer HY, Matsubara S, Lee JC (1989). The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs. Psychopharmacology Bulletin 25, 390-392. (Pubitemid 20260244)
36. Meltzer HY, Stahl SM (1976). The dopamine hypothesis of schizophrenia: a review. Schizophrenia Bulletin 2, 19-76.
37. Meng ZH, Feldpaush DL, Merchant KM (1998). Clozapine and haloperidol block the induction of behavioral sensitization to amphetamine and associated genomic responses in rats. Brain Research. Molecular Brain Research 61, 39-50.
38. Moore H, Jentsch JD, Ghajarnia M, Geyer MA, Grace AA (2006). A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia. Biological Psychiatry 60, 253-264. (Pubitemid 44093447)
39. Natesan S, Reckless GE, Nobrega JN, Fletcher PJ, Kapur S (2006). Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models. Neuropsychopharmacology 31, 1854-1863. (Pubitemid 44246331)
40. ODonnell P, Grace AA (1994). Tonic D2-mediated attenuation of cortical excitation in nucleus accumbens neurons recorded in vitro. Brain Research 634, 105-112. (Pubitemid 2027215)
41. ODonnell P, Grace AA (1998). Dysfunctions in multiple interrelated systems as the neurobiological bases of schizophrenic symptom clusters. Schizophrenia Bulletin 24, 267-283.
42. Paxinos G, Watson C (1998). The Rat Brain in Stereotaxic Coordinates, 4th edn. San Diego: Academic Press.
43. Perez MF, White FJ, Hu XT (2006). Dopamine D(2) receptor modulation of K(+) channel activity regulates excitability of nucleus accumbens neurons at different membrane potentials. Journal of Neurophysiology 96, 2217-2228.
44. Pucak ML, Grace AA (1996). Effects of haloperidol on the activity and membrane physiology of substantia nigra dopamine neurons recorded in vitro. Brain Research. Molecular Brain Research 713, 44-52.
45. Sams-Dodd F (1997). Effect of novel antipsychotic drugs on phencyclidine-induced stereotyped behaviour and social isolation in the rat social interaction test. Behavioural Pharmacology 8, 196-215. (Pubitemid 27303915)
46. Seeman P, Chau-Wong M, Tedesco J, Wong K (1975). Brain receptors for antipsychotic drugs and dopamine: direct binding assays. Proceedings of the National Academy of Sciences USA 72, 4376-4380.
47. Skarsfeldt T (1992). Electrophysiological profile of the new atypical neuroleptic, sertindole, on midbrain dopamine neurones in rats: acute and repeated treatment. Synapse 10, 25-33.
48. Skarsfeldt T (1995). Differential effects of repeated administration of novel antipsychotic drugs on the activity of midbrain dopamine neurons in the rat. European Journal of Pharmacology 281, 289-294.
49. Skarsfeldt T, Perregaard J (1990). Sertindole, a new neuroleptic with extreme selectivity on A10 versus A9 dopamine neurones in the rat. European Journal of Pharmacology 182, 613-614. (Pubitemid 20260788)
50. Skirboll LR, Grace AA, Bunney BS (1979). Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists. Science 206, 80-82.
51. Walters JR, Roth RH, Aghajanian GK (1973). Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway. Journal of Pharmacology and Experimental Therapeutics 186, 630-639.
52. Watanabe M, Hagino Y (1999). The atypical antipsychotic sertindole enhances efflux of dopamine and its metabolites in the rat cortex and striatum. European Journal of Pharmacology 367, 19-23. (Pubitemid 29094610)