Behavioral evidence of depolarization block of dopamine neurons after chronic treatment with haloperidol and clozapine

Journal of Neuroscience

Volumn 20, Issue 3, 2000, Pages 1229-1239

  Boye, Sandra M ^a,d   Rompré, Pierre Paul ^a,b,c  

^a and Applied Physiology   (Canada)

^b Centre de Recherche Hopital Du Sacre Coeur de Montreal   (Canada)

^c CENTRE DE RECHERCHE FERNAND SEGUIN   (Canada)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Apomorphine; Behavioral supersensitivity; Clozapine; Depolarization block; Dopamine; Haloperidol; Reward

Indexed keywords

APOMORPHINE; CLOZAPINE; HALOPERIDOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DOPAMINERGIC NERVE CELL; DRUG WITHDRAWAL; ELECTROSTIMULATION; MALE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; REWARD;

EID: 0034143362     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-03-01229.2000     Document Type: Article

References (42)

1. Akaoka H, Charléty F, Saunier C-F, Buda M, Chouvet G (1992) Inhibition of nigral dopamine neurons by systemic and local apomorphine: possible contribution of dendritic autoreceptors. Neuroscience 49:879-891.
2. Barros HMT, Braz S, Carlini EA (1989) Behavioural manifestations elicited by apomorphine, influence of the route of administration. Pharmacology 38:335-340.
3. Boye SM, Rompré P-P (1996) Effect of pimozide on self-stimulation thresholds under a continuous and fixed-interval schedule of reinforcement. Behav Brain Res 78:243-245.
4. Bunney BS, Grace AA (1978) Acute and chronic haloperidol treatment: comparison of effects on nigral dopaminergic cell activity. Life Sci 23:1715-1728.
5. Burt DR, Creese I, Snyder SH (1977) Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science 196:326-328.
6. Chiodo LA, Bunney BS (1983) Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. J Neurosci 3:1607-1619.
7. Chiodo LA, Bunney BS (1985) Possible mechanisms by which clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. J Neurosci 5:2539-2544.
8. Clow A, Theodorou A, Jenner P, Marsden CD (1980) A comparison of striatal and mesolimbic dopamine function in the rat during 6-month trifluoperazine administration. Psychopharmacology 69:227-233.
9. Doherty MD, Gratton A (1991) Behavioral evidence of depolarization block of mesencephalic dopamine neurons by acute haloperidol in partially 6-hydroxydopamine lesioned rats. Behav Neurosci 105:579-587.
10. Fouriezos G, Francis S (1992) Apomorphine and electrical self-stimulation of the rat brain. Behav Brain Res 52:73-80.
11. Freeman AS, Bunney BS (1987) Activity of A9 and AlO dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin. Brain Res 405:46-55.
12. Gallistel CR, Freyd G (1987) Quantitative determination of the effects of catecholaminergic agonists and antagonists on the rewarding efficacy of brain stimulation. Pharmacol Biochem Behav 26:731-741.
13. Gallistel CR, Karras D (1984) Pimozide and amphetamine have opposing effects on the reward summation function. Pharmacol Biochem Behav 20:73-77.
14. Gardner EL, Seeger TF (1988) Anatomically selective action of atypical neuroleptics on the mesocorticolimbic dopamine system. Ann NY Acad Sci 537:502-504.
15. Gardner EL, Walker LS, Paredes W (1993) Clozapine's functional mesolimbic selectivity is not duplicated by the addition of anticholinergic action to haloperidol: a brain stimulation study in the rat. Psychopharmacology 110:119-124.
16. Grace AA, Bunney BS (1985) Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology. Brain Res 333:285-298.
17. Grace AA, Bunney BS (1986) Induction of depolarization block in midbrain dopamine neurons by repeated haloperidol: analysis using in vivo intracellular recording. J Pharmacol Exp Ther 238:1092-1100.
18. Grace AA, Bunney BS, Moore H, Todd CL (1997) Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. Trends Neurosci 20:31-37.
19. Hollerman JR, Abercrombie ED, Grace AA (1992) Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons. Neuroscience 47:589-601.
20. Melis M, Mereu G, Lilliu V, Quartu M, Diana M, Gessa GL (1998) Haloperidol does not produce dopamine cell depolarization-block in paralyzed, unanesthetized rats. Brain Res 783:127-132.
21. Melzacka M, Wiszniowska G, Vetulani J (1978) The distribution of apomorphine in rat brain: possible behavioral correlates. Pol J Pharmacol Pharm 30:335-345.
22. Mereu G, Lilliu V, Vargiu P, Muntoni AL, Diana M, Gessa GL (1994) Failure of chronic haloperidol to induce depolarization inactivation of dopamine neurons in unanesthetized rats. Eur J Pharmacol 264:449-453.
23. Mereu G, Lilliu V, Vargiu P, Muntoni AL, Diana M, Gessa GL (1995) Depolarization inactivation of dopamine neurons: an artifact? J Neurosci 15: 1144-1149.
24. Miliaressis E, Rompré P-P, Laviolette P, Philippe L, Coulombe D (1986) The curve-shift paradigm in self-stimulation. Physiol Behav 37:85-91.
25. Moisan J, Rompré P-P (1998) Electrophysiological evidence that a subset of midbrain dopamine neurons integrate the reward signal induced by electrical stimulation of the posterior mesencephalon. Brain Res 786:143-152.
26. Nowak JZ, Arbilla S, Galzin AM, Langer SZ (1983) Changes in sensitivity of release modulating dopamine autoreceptors after chronic treatment with haloperidol. J Pharmacol Exp Ther 226:558-564.
27. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. New York: Academic.
28. Robertson A, Macdonald C (1986) The effects of some atypical neuroleptics on apomorphine-induced behaviors as a measure of their relative potencies in blocking presynaptic versus postsynaptic receptors. Pharmacol Biochem Behav 24:1639-1643.
29. Rompré P-P, Wise RA (1989) Behavioral evidence for midbrain dopamine depolarization inactivation. Brain Res 477:152-156.
30. Rupniak NMJ, Kilpatrick G, Hall MD, Jenner P, Marsden CD (1984) Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats. Psychopharmacology 84:512-519.
31. Rupniak NMJ, Hall MD, Mann S, Fleminger S, Kilpatrick G, Jenner P, Marsden CD (1985) Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat. Biochem Pharmacol 34:2755-2763.
32. Sailer CF, Salama AI (1985) Alterations in dopamine metabolism after chronic administration of haloperidol. Possible role of increased auto-receptor sensitivity. Neuropharmacology 24:123-129.
33. Schotte A, Janssen PFM, Megens AAHP, Leysen JE (1993) Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography. Brain Res 631:191-202.
34. Seeger TF, Gardner EL (1979) Enhancement of self-stimulation behavior in rats and monkeys after chronic neuroleptic treatment: evidence for mesolimbic supersensitivity. Brain Res 175:49-57.
35. Skarsfeldt T (1988) Differential effects after repeated treatment with haloperidol, clozapine, thioridazine and tefludazine on SNC and VTA dopamine neurones in rats. Life Sci 42:1037-1044.
36. Skarsfeldt T (1994) Comparison of short-term administration of sertindole, clozapine and haloperidol on the inactivation of midbrain dopamine neurons in the rat. Eur J Pharmacol 254:291-294.
37. Skirholl LR, Grace AA, Bunney BS (1979) Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists. Science 206:80-82.
38. Stefanini E, Frau M, Gessa GL (1991) Increase in D2 dopamine receptors in the substantia nigra after chronic (-)-sulpiride treatment. Brain Res 555:340-342.
39. White FJ, Wang RY (1983a) Comparison of the effects of chronic haloperidol treatment on A9 and AlO dopamine neurons in the rat. Life Sci 32:983-993.
40. White FJ, Wang RY (1983b) Differential effects of classical and atypical antipsychotic drugs on A9 and A10 dopamine neurons. Science 221:1054-1057.
41. Wise RA (1996) Addictive drugs and brain stimulation reward. Ann Rev Neurosci 19:319-340.
42. Wise RA, Rompré P-P (1989) Brain dopamine and reward. Ann Rev Psychol 40:191-225.