메뉴 건너뛰기




Volumn 110, Issue 7 SUPPL. 7, 2010, Pages

Incretin physiology and its role in type 2 diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

ADAMANTANE; ANTIDIABETIC AGENT; DIPEPTIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DRUG DERIVATIVE; EXENDIN 4; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; INCRETIN; INSULIN; LIRAGLUTIDE; PEPTIDE; PYRAZINE DERIVATIVE; SAXAGLIPTIN; SITAGLIPTIN; TRIAZOLE DERIVATIVE; VENOM;

EID: 77957232105     PISSN: 00986151     EISSN: 00986151     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (1)

References (23)
  • 1
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck MA, Homberger E, Siegel EG, Allen RC, Eaton RP, Ebert R, et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab. 1986;63(2):492-498.
    • (1986) J Clin Endocrinol Metab , vol.63 , Issue.2 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3    Allen, R.C.4    Eaton, R.P.5    Ebert, R.6
  • 2
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • Accessed July 1, 2010
    • Farilla L, Hui H, Bertolotto C, Kang E, Bulotta A, Di Mario U, et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology. 2002;143 (11):4397-4408. http://endo.endojournals.org/cgi/content/full/143/11/4397. Accessed July 1, 2010.
    • (2002) Endocrinology , vol.143 , Issue.11 , pp. 4397-4408
    • Farilla, L.1    Hui, H.2    Bertolotto, C.3    Kang, E.4    Bulotta, A.5    di Mario, U.6
  • 3
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W. Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1993;36(8):741-744.
    • (1993) Diabetologia , vol.36 , Issue.8 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 4
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • Vilsbøll T, Agersø H, Krarup T, Holst JJ. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab. 2003;88(1):220-224. http://jcem.endojournals.org/cgi/content/full/88/1/220. Accessed July 1, 2010.
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.1 , pp. 220-224
    • Vilsbøll, T.1    Agersø, H.2    Krarup, T.3    Holst, J.J.4
  • 5
    • 31844443202 scopus 로고    scopus 로고
    • Glucagon-like peptide-1: From extract to agent. The Claude Bernard Lecture, 2005 [published online ahead of print January 14, 2006]
    • Holst JJ. Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005 [published online ahead of print January 14, 2006]. Diabetologia. 2006;49(2):253-260.
    • (2006) Diabetologia , vol.49 , Issue.2 , pp. 253-260
    • Holst, J.J.1
  • 6
    • 0014951784 scopus 로고
    • Abnormal alpha-cell function in diabetes: Response to carbohydrate and protein ingestion
    • Müller WA, Faloona GR, Aguilar-Parada E, Unger RH. Abnormal alpha-cell function in diabetes: response to carbohydrate and protein ingestion. N Engl J Med. 1970;283(3):109-115.
    • (1970) N Engl J Med , vol.283 , Issue.3 , pp. 109-115
    • Müller, W.A.1    Faloona, G.R.2    Aguilar-Parada, E.3    Unger, R.H.4
  • 7
    • 0038497464 scopus 로고    scopus 로고
    • Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
    • Accessed July 1, 2010
    • Kolterman OG, Buse JB, Fineman MS, Gaines E, Heintz S, Bicsak TA, et al. Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab. 2003;88(7):3082-3089. http://jcem.endojournals.org/cgi/content/full/88/7/3082. Accessed July 1, 2010.
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.7 , pp. 3082-3089
    • Kolterman, O.G.1    Buse, J.B.2    Fineman, M.S.3    Gaines, E.4    Heintz, S.5    Bicsak, T.A.6
  • 9
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen J, Holst JJ. Effect of 6-week course of glucagon-like peptide on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet. 2002;359(9309):824-830.
    • (2002) Lancet , vol.359 , Issue.9309 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.3    Holst, J.J.4
  • 10
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • Accessed July 1, 2010
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care. 2005;28(5):1092-1100. http://care.diabetesjournals.org/content/28/5/1092.long. Accessed July 1, 2010.
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1092-1100
    • de Fronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 11
    • 7444228521 scopus 로고    scopus 로고
    • Exenatide-113 Clinical Study Group. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Accessed July 1, 2010
    • Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD; Exenatide-113 Clinical Study Group. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care. 2004;27(11): 2628-2635. http://care.diabetesjournals.org/content/27/11/2628.long. Accessed July 1, 2010.
    • (2004) Diabetes Care , vol.27 , Issue.11 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 12
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Accessed July 1, 2010
    • Kendall DM, Riddle MC, Rosenstock J, Zhuang D, Kim DD, Fineman MS, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care. 2005; 28(5):1083-1091. http://care.diabetesjournals.org/content/28/5/1083.long. Accessed July 1, 2010.
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.D.5    Fineman, M.S.6
  • 13
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L, Klein EJ, Han J, Zhang B, Mac SM, Poon TH, et al. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab. 2006;8(4):436-447.
    • (2006) Diabetes Obes Metab , vol.8 , Issue.4 , pp. 436-447
    • Blonde, L.1    Klein, E.J.2    Han, J.3    Zhang, B.4    Mac, S.M.5    Poon, T.H.6
  • 14
    • 26944477362 scopus 로고    scopus 로고
    • Exenatideversus insulin glargine in patients with suboptimally controlled type 2 diabetes: A randomized trial
    • GWAA Study Group
    • Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG; GWAA Study Group. Exenatideversus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med. 2005;143(8):559-569.
    • (2005) Ann Intern Med , vol.143 , Issue.8 , pp. 559-569
    • Heine, R.J.1    van Gaal, L.F.2    Johns, D.3    Mihm, M.J.4    Widel, M.H.5    Brodows, R.G.6
  • 15
    • 34249869806 scopus 로고    scopus 로고
    • Liraglutide, a longacting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes [published online ahead of print March 19,2007]
    • Accessed July 1, 2010
    • Vilsbøll T, Zdravkovic M, Le-Thi T, Krarup T, Schmitz O, Courrèges JP, et al. Liraglutide, a longacting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes [published online ahead of print March 19,2007]. Diabetes Care. 2007;30(6):1608-1610. http://care.diabetesjournals.org/content/30/6/1608.long.Accessed July 1, 2010.
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1608-1610
    • Vilsbøll, T.1    Zdravkovic, M.2    Le-Thi, T.3    Krarup, T.4    Schmitz, O.5    Courrèges, J.P.6
  • 17
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses
    • Herman GA, Stevens C, Van Dyck K, Bergman A, Yi B, De Smet M, et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clin Pharmacol Ther. 2005;78(6):675-688.
    • (2005) Clin Pharmacol Ther , vol.78 , Issue.6 , pp. 675-688
    • Herman, G.A.1    Stevens, C.2    van Dyck, K.3    Bergman, A.4    Yi, B.5    de Smet, M.6
  • 18
    • 32844473903 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: A double-blind, randomized, placebo-controlled study in healthy male volunteers
    • Bergman AJ, Stevens C, Zhou Y, Yi B, Laethem M, De Smet M, et al. Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebo-controlled study in healthy male volunteers. Clin Ther. 2006;28(1):55-72.
    • (2006) Clin Ther , vol.28 , Issue.1 , pp. 55-72
    • Bergman, A.J.1    Stevens, C.2    Zhou, Y.3    Yi, B.4    Laethem, M.5    de Smet, M.6
  • 19
    • 33845472504 scopus 로고    scopus 로고
    • Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Accessed July 1, 2010
    • Aschner P, Kipnes MS, Lunceford JK, Sanchez M, Mickel C, Williams-Herman DE; Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 2006;29(12):2632-2637. http://care.diabetesjournals.org/content/29/12/2632.long. Accessed July 1, 2010.
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3    Sanchez, M.4    Mickel, C.5    Williams-Herman, D.E.6
  • 20
    • 33845476757 scopus 로고    scopus 로고
    • Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Accessed July 1, 2010
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G; Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006; 29(12):2638-2643. http://care.diabetesjournals.org/content/29/12/2638.long. Accessed July 1, 2010
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 21
    • 33846817233 scopus 로고    scopus 로고
    • Sitagliptin Study 024 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, non-inferiority trial
    • Nauck MA, Meininger G, Sheng D, Terranella L, Stein PP; Sitagliptin Study 024 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab. 2007;9(2):194-205.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3    Terranella, L.4    Stein, P.P.5
  • 22
    • 65549123794 scopus 로고    scopus 로고
    • CV181-039 Investigators. Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: A randomized controlled trial
    • Jadzinsky M, Pfützner A, Paz-Pacheco E, Xu Z, Allen E, Chen R; CV181-039 Investigators. Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: a randomized controlled trial. Diabetes Obes Metab. 2009;11(6):611-622.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.6 , pp. 611-622
    • Jadzinsky, M.1    Pfützner, A.2    Paz-Pacheco, E.3    Xu, Z.4    Allen, E.5    Chen, R.6
  • 23
    • 67649666737 scopus 로고    scopus 로고
    • LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) [published online ahead of print June 8, 2009]
    • Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH, et al; LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) [published online ahead of print June 8, 2009]. Lancet. 2009;374(9683):39-47.
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.