Blood glucose lowering potential of Stem Bark of Berberis aristata Dc in Alloxan-induced diabetic rats

Iranian Journal of Pharmacology and Therapeutics

Volumn 9, Issue 1, 2010, Pages 21-24

  Gupta, J K ^a   Mishra, P ^a   Rani, A ^b   Mitra Mazumder, P ^c  

^a GLA Institute of Pharmaceutical Sciences and Research   (India)

^b Arya Group of Colleges   (India)

^c BIRLA INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Alloxan; Antidiabetc activity; Antioxidant; Berberis aristata; Methanolic extract; Phenolic content

Indexed keywords

ALLOXAN; ANTIDIABETIC AGENT; BERBERIS ARISTATA EXTRACT; CARBOXYMETHYLCELLULOSE; CHLOROFORM; GALLIC ACID; GLIBENCLAMIDE; GLUCOSE; METHANOL; PETROLEUM ETHER; PHENOL; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BARK; BERBERIS; BERBERIS ARISTATA; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG ACTIVITY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; IN VITRO STUDY; LD 50; MALE; NONHUMAN; PHYTOCHEMISTRY; PLANT STEM; RAT; SOXHLET EXTRACTION; TOXICITY TESTING;

EID: 77957231962     PISSN: 17352657     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Frier BM, Fischer BM. Diabetes mellitus. In: Davidson's Principles and Practice of Medicine, ed. 19, Pub. Churchill Livingstone, 2002; p 644.
2. Robertson RP, Harman JS. Diabetes, glucose toxicity and oxidative stress: a case of double jeopardy for the pancreatic islets βcell. Free Radic Biol Med 2006; 41:177-84.
3. Kameswra RB, Appa Rao CH. Hypoglycemic and antihyperglycemic activity of alternifolium (Wt.) Walp. seed extracts in normal and diabetic rats. Phytomedicine 2001; 8:88-93.
4. Anonymous. The Wealth of India, PID5CSIR; New Delhi, 1965; 1: pp 114-9.
5. Kirtikar KR, Basu BD. Indian Medicinal Plants I, Lalit Mohan Basu and Co., Allahabad; 1933.
6. Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants.Vol.3 CDRI, Lucknow and PID CSIR, New Delhi; 1993.
7. Sohni YR, Bhatt RM. Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies. J Ethnopharmacol 1996; 54: 119-24.
8. Mitra SK, Gopumadhavan S, Muralidhar TS, Anturlikar SD, Sujatha MB. Effect of a herbomineral preparation D-400 in streptozotocin-induced diabetic rats. J Ethnopharmacol 1996; 54:41-6.
9. Miller LC, Tainter ML. Estimation of the LD-50 and its error by means of logarithmic-robit graph paper. Proc Soc Exp Biol Med 1944; 57:261.
10. Muller G. Drug Discovery and Evaluation. In: Pharmacological Assays. Vogel HG, Vogel WH. Springer-Verlag Berlin Heidelberg, 2002; pp 950-951.
11. Badole S, Patel N, Bodhankar S, Jain B, Bhardwaj S. Antihyperglycemic activity of aqueous extract of leaves of Cocullus hirsutus (L) Diels in alloxan-induced diabetic mice. Ind J Pharmacol 2006; 38: 49-53.
12. Godkar BP, Godkar DP. Textbook of Medical Laboratory Technology, ed. 2, Publ. Bhalani Publishing House, Mumbai, India, 2006; pp 48,190,235,251,340,352,387,77.
13. Folin O, Ciocalteu V. On Tyrosine and Tryptophane determinations in proteins. J Biol Chem. 1927; 73:627-50.
14. Mallurwar VR, Pathak AK. Hepatoprotective and antioxidant activity of fresh aerial roots of Ficus bengalensis. Ind J Nat Prod 2006; 23:8-11.
15. Yen GC, Chen HY. Antioxidant activity of various tea extracts in relation to their antimutagenicity. J Agric Food Chem 1995; 46:849-54.
16. Semwal BC, Shah K, Chauhan NS, Badha R, Divakar K. Anti-diabetic activity of stem bark of Berberis aristata D.C. in alloxan-induced diabetic rats. Internet J Pharmacol 2008; 6, November 1.