Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing

EMBO Reports

Volumn 11, Issue 10, 2010, Pages 765-771

  Chang, Jolie L ^a   Brauer, Delia S ^b   Johnson, Jacob ^a   Chen, Carol G ^a   Akil, Omar ^a   Balooch, Guive ^c,d   Humphrey, Mary Beth ^e   Chin, Emily N ^a   Porter, Alexandra E ^f   Butcher, Kristin ^a   Ritchie, Robert O ^c,d   Schneider, Richard A ^a   Lalwani, Anil ^g   Derynck, Rik ^a,b   Marshall, Grayson W ^a,b   Marshall, Sally J ^b   Lustig, Lawrence ^a   Alliston, Tamara ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c No 1760   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g NEW YORK UNIVERSITY   (United States)

Author keywords

bone quality; elastic modulus; hearing; Runx2; TGF beta

Indexed keywords

TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MATRIX; BONE MINERALIZATION; CELL DIFFERENTIATION; CLEIDOCRANIAL DYSPLASIA; COCHLEA; EXTRACELLULAR MATRIX; HEARING; HEARING LOSS; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; BONE CONDUCTION; BONE DEVELOPMENT; BONE MATRIX; CELL DIFFERENTIATION; CLEIDOCRANIAL DYSPLASIA; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DISEASE MODELS, ANIMAL; ELASTIC MODULUS; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, INBRED C57BL; OSTEOBLASTS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

MUS;

EID: 77957228438     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2010.135     Document Type: Article

References (24)

1. Akil O, Chang J, Hiel H, Kong JH, Yi E, Glowatzki E, Lustig LR (2006) Progressive deafness and altered cochlear innervation in knock-out mice lacking prosaposin. J Neurosci 26: 13076?13088. (Pubitemid 44954626)
2. Alliston T, Choy L, Ducy P, Karsenty G, Derynck R (2001) TGFβ-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J 20: 2254-2272. (Pubitemid 32410595)
3. Arany PR, Flanders KC, Kobayashi T, Kuo CK, Stuelten C, Desai KV, Tuan R, Rennard SI, Roberts AB (2006) Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure. Proc Natl Acad Sci USA 103: 9250-9255. (Pubitemid 43902564)
4. Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T (2005) TGFβ regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci USA 102: 18813-18818. (Pubitemid 43049527)
5. Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M (2007) Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc Natl Acad Sci USA 104: 10164-10169 (Pubitemid 47175280)
6. Butcher DT, Alliston T, Weaver VM (2009) A tense situation: forcing tumour progression. Nat Rev Cancer 9: 108-122
7. Chole RA, McKenna M (2001) Pathophysiology of otosclerosis. Otol Neurotol 22: 249-257
8. Cooper SC, Flaitz CM, Johnston DA, Lee B, Hecht JT (2001) A natural history of cleidocranial dysplasia. Am J Med Genet 104: 1-6
9. Currey JD (1999) The design of mineralised hard tissues for their mechanical functions. J Exp Biol 202: 3285-3294
10. Erlebacher A, Derynck R (1996) Increased expression of TGFβ2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol 132: 195-210 (Pubitemid 26035085)
11. Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R (1999) Inhibition of TGFβ receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development 126: 4267-4279 (Pubitemid 29509342)
12. Hartikka H, Kuurila K, Korkko J, Kaitila I, Grenman R, Pynnonen S, Hyland JC, Ala-Kokko L (2004) Lack of correlation between the type of COL1A1 or COL1A2 mutation and hearing loss in osteogenesis imperfecta patients. Hum Mut 24: 147-154 (Pubitemid 39006594)
13. Higashi K, Matsuki C (1996) Hearing impairment in Engelmann disease. Am J Otol 17: 26-29 (Pubitemid 26111119)
14. Kanzaki S, Ito M, Takada Y, Ogawa K, Matsuo K (2006) Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin. Bone 39: 414-419 (Pubitemid 43851371)
15. Mohammad KS, et al. (2009) Pharmacologic inhibition of the TGFβ type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS ONE 4: e5275
16. Monsell EM (2004) The mechanism of hearing loss in Paget?s disease of bone. Laryngoscope 114: 598-606 (Pubitemid 38548766)
17. Otto F, et al. (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89: 765-771 (Pubitemid 27516179)
18. Rho JY, Tsui TY, Pharr GM (1997) Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation. Biomaterials 18: 1325-1330
19. Seal RP, et al. (2008) Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron 57: 263-275
20. Sorensen MS (1994) Temporal bone dynamics, the hard way. Formation, growth, modeling, repair and quantum type bone remodeling in the otic capsule. Acta Otolaryngol 512: 1-22
21. Thurner PJ, Chen CG, Ionova-Martin S, Sun L, Harman A, Porter A, Ager JW III, Ritchie RO, Alliston T (2010) Osteopontin deficiency increases bone fragility but preserves bone mass. Bone 46: 1564-1573
22. Visosky AM, Johnson J, Bingea B, Gurney T, Lalwani AK (2003) Otolaryngological manifestations of cleidocranial dysplasia, concentrating on audiological findings. Laryngoscope 113: 1508-1514 (Pubitemid 37087830)
23. Zehnder AF, Kristiansen AG, Adams JC, Kujawa SG, Merchant SN, McKenna MJ (2006) Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss. Laryngoscope 116: 201-206
24. Zhang YW, Yasui N, Ito K, Huang G, Fujii M, Hanai J, Nogami H, Ochi T, Miyazono K, Ito Y (2000) A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci USA 97: 10549-10554