Urinary biomarkers-silver bullets to faster drug development and nephron protection

Nephrology Dialysis Transplantation

Volumn 25, Issue 10, 2010, Pages 3167-3169

  Haase, Michael ^a,b   Mertens, Peter R ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

biomarkers; creatinine; drug development; nephrotoxicity; NGAL

Indexed keywords

CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

CREATININE BLOOD LEVEL; DISEASE MARKER; HISTOPATHOLOGY; HUMAN; KIDNEY INJURY; NEPHRON; NOTE; PRIORITY JOURNAL; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL;

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; BIOLOGICAL MARKERS; BLOOD UREA NITROGEN; CREATININE; DRUG DISCOVERY; HUMANS; LIPOCALINS; NEPHRONS; PROTO-ONCOGENE PROTEINS;

EID: 77957224850     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq504     Document Type: Note

References (19)

1. Uchino S, Kellum JA, Bellomo R et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005; 294: 813-818
2. Dieterle F, Perentes E, Cordier A et al. Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nat Biotechnol 2010; 28: 463-469
3. Yu Y, Jin H, Holder D et al. Urinary biomarkers trefoil factor 3 and albumin enable early detectionofkidney tubular injury. Nat Biotechnol 2010; 28: 470-477
4. Vaidya VS, Ozer JS, Dieterle F et al. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical bio-marker qualification studies. Nat Biotechnol 2010; 28: 478-485
5. Ozer JS, Dieterle F, Troth S et al. A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function. Nat Biotechnol 2010; 28: 486-494
6. Correa-Rotter R, Ibarra-Rubio ME, Schwochau G et al. Induction of clusterin in tubules of nephrotic rats. J Am Soc Nephrol 1998; 9: 33-37
7. Tsuchiya Y, Tominaga Y, Mitsubayashi K et al. Investigation on urinary proteins and renal mRNA expression in canine renal papillary necrosis induced by nefiracetam. Arch Toxicol 2005; 79: 500-507
8. D'Amico G, Bazzi C. Pathophysiology of proteinuria. Kidney Int 2003; 63: 809-825
9. Haase-Fielitz A, Bellomo R, Devarajan P et al. Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery\a prospective cohort study. Crit Care Med 2009; 37: 553-560
10. Haase M, Bellomo R, Devarajan P et al. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 2009; 54: 1012-1024
11. Supavekin S, Zhang W, Kucherlapati R et al. Differential gene expression following early renal ischemia/reperfusion. Kidney Int 2003; 63: 1714-1724
12. Mishra J, Ma Q, Prada A et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 2003; 14: 2534-2543
13. Mishra J, Dent C, Tarabishi R et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365: 1231-1238
14. Mori K, Lee HT, Rapoport D et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfu-sion injury. J Clin Invest 2005; 115: 610-621
15. Dent CL, Ma Q, Dastrala S et al. Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care 2007; 11: R127
16. Bennett M, Dent CL, Ma Q et al. Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol 2008; 3: 665-673
17. Haase M, Haase-Fielitz A, Bellomo R et al. Sodium bicarbonate to prevent acute kidney injury after cardiopulmonary bypass\a multiple-blind, randomized controlled trial. Crit Care Med 2009; 37: 39-47
18. Mishra J, Mori K, Ma Q et al. Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 2004; 24: 307-315
19. Gaspari F, Cravedi P, Mandalà M et al. Predicting cisplatin-induced acute kidney injury by urinary neutrophil gelatinase- associated lipocalin excretion: a pilot prospective case-control study. Nephron Clin Pract 2010; 115: c145-c160