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Volumn 94, Issue 5, 2010, Pages 1793-1798

Comparison of effects of 3 mg drospirenone plus 20 μg ethinyl estradiol alone or combined with metformin or cyproterone acetate on classic metabolic cardiovascular risk factors in nonobese women with polycystic ovary syndrome

Author keywords

cyproterone acetate; drospirenone; metformin; PCOS

Indexed keywords

CHOLESTEROL; CYPROTERONE ACETATE; DROSPIRENONE; ETHINYLESTRADIOL; GLUCOSE; INSULIN; LIPID; METFORMIN; ORAL CONTRACEPTIVE AGENT; UNCLASSIFIED DRUG; YASMINELLE; ANDROGEN; ANDROSTANE DERIVATIVE; ANTIDIABETIC AGENT; CYPROTERONE; ESTROGEN; MINERALOCORTICOID ANTAGONIST;

EID: 77957196511     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.10.016     Document Type: Article
Times cited : (34)

References (38)
  • 1
    • 0343528010 scopus 로고    scopus 로고
    • Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome
    • D. Cibula, R. Cifkova, M. Fanta, R. Poledne, J. Zivny, and J. Skibova Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome Hum Reprod 15 2000 785 789
    • (2000) Hum Reprod , vol.15 , pp. 785-789
    • Cibula, D.1    Cifkova, R.2    Fanta, M.3    Poledne, R.4    Zivny, J.5    Skibova, J.6
  • 2
    • 33846086155 scopus 로고    scopus 로고
    • Atherogenic lipoprotein phenotype and low-density lipoproteins size and subclasses in women with polycystic ovary syndrome
    • K. Berneis, M. Rizzo, V. Lazzarini, F. Fruzzetti, and E. Carmina Atherogenic lipoprotein phenotype and low-density lipoproteins size and subclasses in women with polycystic ovary syndrome J Clin Endocrinol Metab 92 2007 186 189
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 186-189
    • Berneis, K.1    Rizzo, M.2    Lazzarini, V.3    Fruzzetti, F.4    Carmina, E.5
  • 3
    • 0036342694 scopus 로고    scopus 로고
    • Global fibrinolytic capacity is decreased in polycystic ovary syndrome, suggesting a prothrombotic state
    • B.O. Yildiz Haznedarolu IC, Kirazli S, Bayraktar M. Global fibrinolytic capacity is decreased in polycystic ovary syndrome, suggesting a prothrombotic state J Clin Endocrinol Metab 87 2002 3871 3875
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3871-3875
    • Yildiz, B.O.1    Haznedarolu, I.C.2    Kirazli, S.3    Bayraktar, M.4
  • 4
    • 20144382250 scopus 로고    scopus 로고
    • Insulin resistance causes impaired vasodilation and hypofibrinolysis in young women with polycystic ovary syndrome
    • F. Carmassi, F. De Negri, R. Fioriti, A. De Giorgi, C. Giannarelli, and F. Fruzzetti Insulin resistance causes impaired vasodilation and hypofibrinolysis in young women with polycystic ovary syndrome Thromb Res 116 2005 207 214
    • (2005) Thromb Res , vol.116 , pp. 207-214
    • Carmassi, F.1    De Negri, F.2    Fioriti, R.3    De Giorgi, A.4    Giannarelli, C.5    Fruzzetti, F.6
  • 6
    • 60549105378 scopus 로고    scopus 로고
    • Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review
    • S. Palomba, A. Falbo, F. Zullo, and F. Orio Jr. Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review Endocr Rev 30 2009 1 50
    • (2009) Endocr Rev , vol.30 , pp. 1-50
    • Palomba, S.1    Falbo, A.2    Zullo, F.3    Orio, Jr.F.4
  • 7
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: Systematic review and meta-analysis
    • J.M. Lord, I.H. Flight, and R.J. Norman Metformin in polycystic ovary syndrome: systematic review and meta-analysis BMJ 327 2003 951 953
    • (2003) BMJ , vol.327 , pp. 951-953
    • Lord, J.M.1    Flight, I.H.2    Norman, R.J.3
  • 8
    • 1842678279 scopus 로고    scopus 로고
    • Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome?
    • K.I. Cheang, and J.E. Nestler Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome? Reprod Biomed Online 8 2004 440 447
    • (2004) Reprod Biomed Online , vol.8 , pp. 440-447
    • Cheang, K.I.1    Nestler, J.E.2
  • 9
    • 17744400090 scopus 로고    scopus 로고
    • Effect of longterm treatment with metformin added to hypocaloric diet on body composition, fat distribution and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome
    • R. Pasquali, A. Gambineri, D. Biscotti, V. Vicennati, L. Gagliardi, and D. Colitta Effect of longterm treatment with metformin added to hypocaloric diet on body composition, fat distribution and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome J Clin Endocrinol Metab 85 2000 2767 2774
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2767-2774
    • Pasquali, R.1    Gambineri, A.2    Biscotti, D.3    Vicennati, V.4    Gagliardi, L.5    Colitta, D.6
  • 10
    • 36549034292 scopus 로고    scopus 로고
    • Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance
    • S. Tan, S. Hahn, S. Benson, T. Dietz, H. Lahner, and L.C. Moeller Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance Eur J Endocrinol 157 2007 669 676
    • (2007) Eur J Endocrinol , vol.157 , pp. 669-676
    • Tan, S.1    Hahn, S.2    Benson, S.3    Dietz, T.4    Lahner, H.5    Moeller, L.C.6
  • 11
    • 0036063322 scopus 로고    scopus 로고
    • Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome: A randomized controlled study
    • K. Elter, G. Imir, and F. Durmusoglu Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome: a randomized controlled study Hum Reprod 17 2002 1729 1737
    • (2002) Hum Reprod , vol.17 , pp. 1729-1737
    • Elter, K.1    Imir, G.2    Durmusoglu, F.3
  • 12
    • 0025634135 scopus 로고    scopus 로고
    • Long-term treatment with the combination ethinylestradiol and cyproterone acetate in polycystic ovary syndrome
    • L. Falsetti, and E. Galbignani Long-term treatment with the combination ethinylestradiol and cyproterone acetate in polycystic ovary syndrome Contraception 42 1999 611 619
    • (1999) Contraception , vol.42 , pp. 611-619
    • Falsetti, L.1    Galbignani, E.2
  • 13
    • 23444459549 scopus 로고    scopus 로고
    • Oral contraceptives and the management of hyperandrogenism-polycystic ovary syndrome in adolescents
    • P.J. Hillard Oral contraceptives and the management of hyperandrogenism-polycystic ovary syndrome in adolescents Endocrinol Metab Clin North Am 34 2005 707 723
    • (2005) Endocrinol Metab Clin North Am , vol.34 , pp. 707-723
    • Hillard, P.J.1
  • 14
    • 0037242513 scopus 로고    scopus 로고
    • Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: A randomized study
    • L. Morin-Papunen, I. Vauhkonen, R. Koivunen, A. Ruokonen, H. Martikainen, and J.S. Tapanainen Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: a randomized study J Clin Endocrinol Metab 88 2003 148 156
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 148-156
    • Morin-Papunen, L.1    Vauhkonen, I.2    Koivunen, R.3    Ruokonen, A.4    Martikainen, H.5    Tapanainen, J.S.6
  • 15
    • 34548799898 scopus 로고    scopus 로고
    • Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: A 12-month, double-blind, parallel clinical trial
    • J. Calaf, E. López, A. Millet, J. Alcañiz, A. Fortuny, and O. Vidal Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism: a 12-month, double-blind, parallel clinical trial J Clin Endocrinol Metab 92 2007 3446 3452
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3446-3452
    • Calaf, J.1    López, E.2    Millet, A.3    Alcañiz, J.4    Fortuny, A.5    Vidal, O.6
  • 16
    • 0025732757 scopus 로고
    • Cyproterone acetate for severe hirsutism: Results of a double-blind dose-ranging study
    • J.H. Barth, C.A. Cherry, F. Wojnarowska, and R.P.R. Dawber Cyproterone acetate for severe hirsutism: results of a double-blind dose-ranging study Clin Endocrinol 35 1991 5 10
    • (1991) Clin Endocrinol , vol.35 , pp. 5-10
    • Barth, J.H.1    Cherry, C.A.2    Wojnarowska, F.3    Dawber, R.P.R.4
  • 18
    • 0037382633 scopus 로고    scopus 로고
    • Use of cyproterone acetate, finasteride and spironolactone to treat idiopathic hirsutism
    • F. Lumachi, and R. Rondinone Use of cyproterone acetate, finasteride and spironolactone to treat idiopathic hirsutism Fertil Steril 79 2003 942 946
    • (2003) Fertil Steril , vol.79 , pp. 942-946
    • Lumachi, F.1    Rondinone, R.2
  • 19
    • 33846498356 scopus 로고    scopus 로고
    • Polycystic ovary syndrome, oral contraceptives and metabolic issues: New perspectives and a unifying hypothesis
    • S. Nader, and E. Diamanti-Kandarakis Polycystic ovary syndrome, oral contraceptives and metabolic issues: new perspectives and a unifying hypothesis Hum Reprod 22 2007 317 322
    • (2007) Hum Reprod , vol.22 , pp. 317-322
    • Nader, S.1    Diamanti-Kandarakis, E.2
  • 20
    • 1942439064 scopus 로고    scopus 로고
    • Pharmacological profile of progestins
    • R. Sitruk-Ware Pharmacological profile of progestins Maturitas 47 2004 277 283
    • (2004) Maturitas , vol.47 , pp. 277-283
    • Sitruk-Ware, R.1
  • 21
    • 33947506395 scopus 로고    scopus 로고
    • Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome
    • B. Pehlivanov, and M. Mitkov Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome Eur J Contracept Reprod Health Care 12 2007 30 35
    • (2007) Eur J Contracept Reprod Health Care , vol.12 , pp. 30-35
    • Pehlivanov, B.1    Mitkov, M.2
  • 22
    • 2942631366 scopus 로고    scopus 로고
    • Drospirenone for the treatment of hirsute women with polycystic ovary syndrome: A clinical, endocrinological, metabolic pilot study
    • M. Guido, D. Romualdi, M. Giuliani, R. Suriano, L. Selvaggi, and R. Apa Drospirenone for the treatment of hirsute women with polycystic ovary syndrome: a clinical, endocrinological, metabolic pilot study J Clin Endocrinol Metab 89 2004 2817 2823
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2817-2823
    • Guido, M.1    Romualdi, D.2    Giuliani, M.3    Suriano, R.4    Selvaggi, L.5    Apa, R.6
  • 23
    • 0346725827 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome Fertil Steril 81 2004 19 25
    • (2004) Fertil Steril , vol.81 , pp. 19-25
  • 24
    • 0001217801 scopus 로고
    • Diagnostic criteria for polycystic ovary syndrome: Towards a rational approach
    • J.K. Zawadski, and A. Dunaif Diagnostic criteria for polycystic ovary syndrome: towards a rational approach A. Dunaif, J.R. Givens, F. Haseltine, Polycystic ovary syndrome 1992 Blackwell Scientific Boston 377 384
    • (1992) Polycystic Ovary Syndrome , pp. 377-384
    • Zawadski, J.K.1    Dunaif, A.2
  • 26
    • 0036210707 scopus 로고    scopus 로고
    • An open label, comparative study of the effects of a dose-reduced oral contraceptive containing 20 μg ethinyl estradiol and 100 μg levonorgestrel on hemostatic, lipids, and carbohydrate metabolism variables
    • J. Endrikat, C. Klipping, M. Cronin, C. Gerlinger, A. Ruebig, and W. Schmidt An open label, comparative study of the effects of a dose-reduced oral contraceptive containing 20 μg ethinyl estradiol and 100 μg levonorgestrel on hemostatic, lipids, and carbohydrate metabolism variables Contraception 65 2002 215 221
    • (2002) Contraception , vol.65 , pp. 215-221
    • Endrikat, J.1    Klipping, C.2    Cronin, M.3    Gerlinger, C.4    Ruebig, A.5    Schmidt, W.6
  • 27
    • 0023116276 scopus 로고
    • Oral contraception and insulin sensitivity: In vivo assessment in normal women and women with previous gestational diabetes
    • S.O. Skouby, O. Andersen, and N. Saurberey Oral contraception and insulin sensitivity: in vivo assessment in normal women and women with previous gestational diabetes J Clin Endocrinol Metab 64 1987 519 523
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 519-523
    • Skouby, S.O.1    Andersen, O.2    Saurberey, N.3
  • 28
    • 0026788203 scopus 로고
    • Clinical and metabolic effects of a triphasic pill containing gestodene
    • F. Fruzzetti, C. Ricci, I. Nicoletti, and P. Fioretti Clinical and metabolic effects of a triphasic pill containing gestodene Contraception 46 1992 335 347
    • (1992) Contraception , vol.46 , pp. 335-347
    • Fruzzetti, F.1    Ricci, C.2    Nicoletti, I.3    Fioretti, P.4
  • 29
    • 0036165847 scopus 로고    scopus 로고
    • Insulin sensitivity in non-obese women with polycystic ovary syndrome during treatment with oral contraceptives containing low-androgenic progestin
    • D. Cibula, G. Sindelka, M. Hill, M. Fanta, J. Skrha, and J. Zivny Insulin sensitivity in non-obese women with polycystic ovary syndrome during treatment with oral contraceptives containing low-androgenic progestin Hum Reprod 17 2002 76 82
    • (2002) Hum Reprod , vol.17 , pp. 76-82
    • Cibula, D.1    Sindelka, G.2    Hill, M.3    Fanta, M.4    Skrha, J.5    Zivny, J.6
  • 30
    • 0001409084 scopus 로고    scopus 로고
    • Influence of two low dose oral contraceptives containing ethinylestradiol (20 μg) and desogestrel or gestodene on carbohydrate metabolism during 1 year of use
    • U.J. Gaspard, F. Demeyer, C.B. Jaminet, A.J. Scheen, and P.J. Lefebvre Influence of two low dose oral contraceptives containing ethinylestradiol (20 μg) and desogestrel or gestodene on carbohydrate metabolism during 1 year of use Gynecol Endocrinol 10 Suppl 1 1996 179 188
    • (1996) Gynecol Endocrinol , vol.10 , Issue.SUPPL. 1 , pp. 179-188
    • Gaspard, U.J.1    Demeyer, F.2    Jaminet, C.B.3    Scheen, A.J.4    Lefebvre, P.J.5
  • 31
    • 58149147337 scopus 로고    scopus 로고
    • Insulin sensitivity and lipid metabolism with oral contraceptives containing chlormadinone acetate or desogestrel: A randomized trial
    • A. Cagnacci, S. Ferrari, A. Tirelli, R. Zanin, and A. Volpe Insulin sensitivity and lipid metabolism with oral contraceptives containing chlormadinone acetate or desogestrel: a randomized trial Contraception 79 2009 111 116
    • (2009) Contraception , vol.79 , pp. 111-116
    • Cagnacci, A.1    Ferrari, S.2    Tirelli, A.3    Zanin, R.4    Volpe, A.5
  • 33
    • 0041883275 scopus 로고    scopus 로고
    • Glucose metabolism and insulin resistance in women with polycystic ovary syndrome during therapy with oral contraceptive containing cyproterone acetate or desogestrel
    • A. Cagnacci, A.M. Paoletti, A. Renzi, M. Orr, M. Pilloni, and G.B. Melis Glucose metabolism and insulin resistance in women with polycystic ovary syndrome during therapy with oral contraceptive containing cyproterone acetate or desogestrel J Clin Endocrinol Metab 88 2003 3621 3625
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3621-3625
    • Cagnacci, A.1    Paoletti, A.M.2    Renzi, A.3    Orr, M.4    Pilloni, M.5    Melis, G.B.6
  • 34
    • 0023204170 scopus 로고
    • Insulin resistance and decreased tolerance in powerlifters ingesting anabolic steroids
    • J.C. Cohen, and R. Hickman Insulin resistance and decreased tolerance in powerlifters ingesting anabolic steroids J Clin Endocrinol Metab 64 1987 960 963
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 960-963
    • Cohen, J.C.1    Hickman, R.2
  • 35
    • 0038012932 scopus 로고    scopus 로고
    • The effect of aldosterone on glucose metabolism
    • D.B. Corry, and M. Tuck The effect of aldosterone on glucose metabolism Curr Hypertens Rep 5 2003 106 109
    • (2003) Curr Hypertens Rep , vol.5 , pp. 106-109
    • Corry, D.B.1    Tuck, M.2
  • 36
    • 23144456873 scopus 로고    scopus 로고
    • Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes
    • D. Kraus, J. Jager, B. Meier, M. Fasshauer, and J. Klein Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes Horm Metab Res 37 2005 455 459
    • (2005) Horm Metab Res , vol.37 , pp. 455-459
    • Kraus, D.1    Jager, J.2    Meier, B.3    Fasshauer, M.4    Klein, J.5
  • 37
    • 0031789384 scopus 로고    scopus 로고
    • Effects of two antiandrogen treatments on hirsutism and insulin sensitivity in women with polycystic ovary syndrome
    • E. Dahlgren, K. Landin, M. Krotkiewski, G. Holm, and P.O. Janson Effects of two antiandrogen treatments on hirsutism and insulin sensitivity in women with polycystic ovary syndrome Hum Reprod 13 1998 2706 2711
    • (1998) Hum Reprod , vol.13 , pp. 2706-2711
    • Dahlgren, E.1    Landin, K.2    Krotkiewski, M.3    Holm, G.4    Janson, P.O.5
  • 38
    • 0033710083 scopus 로고    scopus 로고
    • Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: A randomized study
    • L. Morin-Papunen, I. Vauhkonen, R.M. Koivunen, A. Ruokonen, H.K. Martikainen, and J.S. Tapanainen Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: a randomized study J Clin Endocrinol Metab 85 2000 3161 3168
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3161-3168
    • Morin-Papunen, L.1    Vauhkonen, I.2    Koivunen, R.M.3    Ruokonen, A.4    Martikainen, H.K.5    Tapanainen, J.S.6


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