Disturbed colonic motility contributes to anorectal symptoms and dysfunction after radiotherapy for carcinoma of the prostate

International Journal of Radiation Oncology Biology Physics

Volumn 78, Issue 3, 2010, Pages 773-780

  Yeoh, Eric K ^a   Bartholomeusz, Dylan L ^a   Holloway, Richard H ^a   Fraser, Robert J ^b   Botten, Rochelle ^a   Di Matteo, Addolorata ^a   Moore, James W ^a   Schoeman, Mark N ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b REPATRIATION GENERAL HOSPITAL   (Australia)

Author keywords

Anorectal manometry; Colonic scintigraphy; Prostate cancer; Radiotherapy

Indexed keywords

COLONIC MOTILITY; COLONIC SCINTIGRAPHY; FECAL INCONTINENCE; INTRA-ABDOMINAL PRESSURES; INVERSE RELATIONSHIP; MANOMETRY; PROSTATE CANCERS; PROSTATE CARCINOMA; RADIATION DOSE; SENSORY FUNCTIONS; SQUEEZE PRESSURE;

DISEASES; MANOMETERS; MORPHOLOGY; NUCLEAR MEDICINE;

RADIOTHERAPY;

ADULT; AGED; ANORECTAL DISEASE; ANORECTAL PRESSURE; ANUS SPHINCTER; ARTICLE; CLINICAL ARTICLE; COLON MOTILITY; FECES INCONTINENCE; HUMAN; INTESTINAL DYSMOTILITY; MALE; MANOMETRY; PRIORITY JOURNAL; PROSTATE CARCINOMA; RADIATION DOSE; RECTUM HEMORRHAGE; SCINTIGRAPHY; ANAL CANAL; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; CLINICAL TRIAL; COLON; COMPLIANCE (PHYSICAL); CONTROLLED STUDY; DEFECATION; FECAL INCONTINENCE; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; MIDDLE AGED; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHASE 3 CLINICAL TRIAL; PHYSIOLOGY; PROSTATIC NEOPLASMS; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; RANDOMIZED CONTROLLED TRIAL; RECTUM; SCINTISCANNING; SENSATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANAL CANAL; ANALYSIS OF VARIANCE; AREA UNDER CURVE; COLON; COMPLIANCE; DEFECATION; DOSE FRACTIONATION; FECAL INCONTINENCE; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; HUMANS; MALE; MIDDLE AGED; ORGAN SIZE; PROSTATIC NEOPLASMS; RECTUM; SENSATION;

EID: 77957192491     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.08.050     Document Type: Article

References (29)

1. E.K. Yeoh, A. Russo, and R. Botten Acute effects of therapeutic irradiation for prostatic carcinoma on anorectal function Gut 43 1998 123 127
2. D.M. Sedgwick, G.C.W. Howard, and A. Ferguson Pathogenesis of acute radiation injury to the rectum: A prospective study in patients Int J Colorect Dis 9 1994 23 30
3. G.E. Hanks External beam radiation therapy for clinically localized prostate cancer: Patterns of care studies in the United States NCI Monogr 7 1988 75 84
4. C.A. Perez, H.K. Lee, and A. Georgion Technical factors affecting morbidity in definitive irradiation for localized carcinoma of the prostate Int J Radiat Oncol Biol Phys 28 1994 811 819
5. A. Widmark, P. Fransson, and B. Tavelin Self-assessment questionnaire for evaluating urinary and intestinal late side effects after pelvic radiotherapy in patients with prostate cancer compared with an age-matched control population Cancer 74 1994 2520 2532
6. E. Yeoh, R. Botten, and A. Russo Chronic effects of therapeutic irradiation for localized prostatic carcinoma on anorectal function Int J Radiat Oncol Biol Phys 47 2000 915 924
7. C.I.V. Franklin, C.A. Parker, and K.M. Morton Late effects of radiation therapy for prostate carcinoma: The patient's perspective of bladder, bowel and sexual morbidity Aust Radiol 42 1998 58 65
8. J.W. Denham, P.C. O'Brien, and R.H. Dunstan Is there more than one late radiation proctitis syndrome? Radiother Oncol 51 1999 43 53
9. E.K. Yeoh, R.J. Fraser, and R. McGowan Evidence for efficacy without increased toxicity of hypofractionated radiation therapy for prostate carcinoma Int J Radiat Oncol Biol Phys 55 2003 943 955
10. E. Yeoh, R. Holloway, and R. Fraser Hypofractionated versus conventionally fractionated radiation therapy for prostate carcinoma: Updated results of a Phase III randomized trial Int J Radiat Oncol Biol Phys 66 2006 1072 1083
11. E. Yeoh, R. Holloway, and R. Fraser Anorectal dysfunction increases with time following radiation therapy for carcinoma of the prostate Am J Gastroenterol 99 2004 361 369
12. E. Yeoh, R.H. Holloway, and R.J. Fraser Anorectal function after three versus two-dimensional radiation therapy for carcinoma of the prostate Int J Radiat Oncol Biol Phys 73 2009 46 52
13. A. Di Matteo, D. Bartolomeusz, and R. Botten Acute effects of radiation therapy for prostate carcinoma on anorectal and colonic motor function J Gastroenterol Hepatol 16 Suppl. 2001 A93
14. A. Di Matteo, D. Bartholomeusz, and R. Botten Regional changes in colonic transit in symptomatic patients following radiation therapy for prostate carcinoma Gastroenterology 122 Suppl. 2002 A319
15. 67Ga-citrate in healthy subjects and those with idiopathic constipation J Nucl Med 40 1999 277 282
16. C. Sale, E. Yeoh, and S. Scutter 2D versus 3D radiation therapy for prostate carcinoma: A direct comparison of dose volume parameters Acta Oncol 44 2005 348 354
17. J. Cohen Comparing two means J. Cohen, Statistical tables for the design of clinical trials 1987 Blackwell Scientific Oxford 79 88
18. D.P. Dearnaley, V.S. Khoo, and A.R. Norman Comparison of radiation side effects of conformal and conventional radiotherapy in prostate cancer: A randomised trial Lancet 353 1999 267 272
19. E. Yeoh, M. Horowitz, and A. Russo Effect of pelvic irradiation on gastrointestinal function: A prospective longitudinal study Am J Med 65 1993 397 406
20. R.C. Spiller Colonic manometry N.W. Read, Gastrointestinal motility: Which test? Petersfield 1989 Wrightson Biomedical Publishing United Kingdom 191 202
21. P.A. Bampton, P.G. Dinning, and M.L. Kennedy The proximal colonic motor response to rectal mechanical and chemical stimulation Am J Physiol Gastrointest Liver Physiol 282 2002 G443 G449
22. A. Pollack, G.K. Zagars, and G. Starkschall Prostate cancer radiation dose response: Results of the M.D. Anderson Phase III randomized trial Int J Radiat Oncol Biol Phys 53 2002 1097 1105
23. D.P. Dearnaley, M.R. Sydes, and J.D. Graham Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: First results from the MRC RT01 randomised controlled trial Lancet Oncol 8 2007 475 487
24. S.T.H. Peeters, W.D. Heemsbergen, and J.V. Lebesque Dose response in radiotherapy of prostate cancer: Results of the Dutch multi-centre randomized Phase III trial comparing 68 Gy radiotherapy with 78 Gy J Clin Oncol 24 2006 1990 1996
25. I.C. Hsu, B. Pickett, and K. Shinohara Normal tissue dosimetric comparison between HDR prostate implant boost and conformal external beam radiotherapy boost: Potential for radiation dose escalation Int J Radiat Oncol Biol Phys 46 2000 851 858
26. M. Read, N.W. Read, and D.C. Barber Effects of loperamide on anal sphincter function in patients complaining of chronic diarrhea with fecal incontinence and urgency Dig Dis Sci 27 1982 807 814
27. E.K. Yeoh, M. Horowitz, and A. Russo Gastrointestinal function in chronic radiation enteritis - effects of loperamide-N-oxide Gut 34 1993 476 482
28. W.M. Sun, C.A. Edwards, and A. Prior Effect of oral nicardipine on anorectal function in normal human volunteers and patients with irritable bowel syndrome Dig Dis Sci 35 1990 885 890
29. P.A. Kupelian, K.M. Langen, and T.R. Willoughby Image-guided radiotherapy for localized prostate cancer: Treating a moving target Semin Radiat Oncol 18 2008 58 66