Effects of pravastatin on cellular ultrastructure and hemorheology in rats after traumatic head injury

Clinical Hemorheology and Microcirculation

Volumn 46, Issue 1, 2010, Pages 1-11

  Hazer, Derya Burcu ^a   Berker, Mustafa ^b   Narin, Firat ^b   Ileri Gurel, Esin ^b   Basak, Ahmet Tulgar ^b   Seringec, Nurten ^b   Kaymaz, Figen ^b   Dikmenoglu, Neslihan ^b   Tuncel, Murvet ^b  

^a Cankiri State Hospital   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

brain injury; cellular ultrastructure; erythrocyte aggregation; erythrocyte deformability; plasma viscosity; pravastatin

Indexed keywords

PRAVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD RHEOLOGY; BLOOD SAMPLING; BLOOD VISCOSITY; CELL ULTRASTRUCTURE; CLINICAL EVALUATION; CONTROLLED STUDY; CRANIECTOMY; DEMYELINATION; ELECTRON MICROSCOPY; ERYTHROCYTE AGGREGATION; ERYTHROCYTE DEFORMABILITY; MALE; MITOCHONDRION; NEUROPROTECTION; NONHUMAN; PLASMA VISCOSITY; RAT; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

ANIMALS; BRAIN; BRAIN INJURIES; HEMORHEOLOGY; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; PRAVASTATIN; RATS; RATS, WISTAR;

EID: 77957169848     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: 10.3233/CH-2010-1328     Document Type: Article

References (38)

1. S. Amin-Hanjani, N.E. Stagliano, M. Yamada, P.L. Huang, J.K. Liao and M.A. Moskowitz, Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice, Stroke 32 (2001), 980-986.
2. Y. Beigel, J. Fuchs, M. Snir and Y. Lurie, Lovastatin therapy in heterozygous familial hypercholesterolemic patients: effect on blood rheology on fibrinogen levels, Journal of Internal Medicine 230 (1991), 23-27.
3. J. Chen, C.Z. Zhang, Y. Li and Y. Weng, Statins induce angiogenesis, neurogenesis and synaptogenesis after stroke, Ann Neurol 53 (2003), 743-751.
4. R. Coccia, C. Spadaccio and C. Foppoli, The effect of simvastatin on erythrocyte membrane fluidity during oxidative stress induced by cardiopulmonary bypass: A randomized controlled study, Clinical Theurapeutics 29(8) (2007), 1706-1717.
5. C.E. Dixon, G.L. Clifton, J.W. Lighthall, A.A. Yaghmai and R.L. Hayes, A controlled cortical impact model of traumatic brain injury in rat, J Neurosci Methods 39 (1991), 253-262.
6. C.A. Dujovne, W.S. Harris and R. Altman, Effect of atorvastatin on hemorheologic-hemostatic parameters and serum fibrinogen levels in hyperlipidemic patients, Nutrition, Metabolism and Cardiovascular Diseases 13(2) (2003), 87-92.
7. M. Eto and T.F. Luscher, Modulation of coagulation and fibrinolytic pathways by statins, Endothelium 10 (2003), 35-41.
8. S. Forconi and T. Gori, The evolution of the meaning of blood hyperviscosity in cardiovascular physiopathology: Should we reinterpret Poiseuille? Clin Hemorheol Microcirc 42(1) (2009), 1-6.
9. M. Frontczak-Baniewicz and M. Walski, New vessel formation after surgical brain injury in the rat's cerebral cortex I. Formation of the blood vessels proximally to the surgical injury, Acta Neurobiol Exp 63 (2003), 65-75. (Pubitemid 36682130)
10. A. Gorgulu, S. Palaoglu, O. Ismailoglu, M. Tuncel, M.T. Surucu, M. Erbil and K. Kilinc, Effect of melatonin on cerebral edema in rats, Neurosurgery 49(6) (2001), 1434-1441.
11. C. Joukhadar, N. Klein, M. Prinz, C. Schrolnberger, T. Vukovich, M. Wolzt, L. Schmetterer and G.T. Dorner, Similar effects of atorvastatin, simvastatin and pravastatin on thrombogenic and inflammatory parameters in patients with hypercholesterolemia, Thromb Haemost 85 (2001), 47-51.
12. E. Kaptanoglu, M. Tuncel, S. Palaoglu, A. Konan, E. Demirpence and K. Kilinc, Comparison of the effect of the melatonin with methylprednisolone in experimental spinal cord injury, Journal of Neurosurgery 93(Suppl. 1) (2000), 77-84.
13. E. Kaptanoglu, S. Sen, E. Beskonakli, H.S. Surucu, M. Tuncel, K. Kilinc and T. Taskin, Antioxidant actions and early ultrastructural findings of thiopental and propofol in experimental spinal cord injury, Journal of Neurosurgical Anesthesiology 14(2) (2002), 114-122.
14. M. Kohno, K. Murokawa and K. Yasunari, Improvement of erythrocyte deformability by cholesterol lowering therapy with pravastatin in hypercholesterolemic patients, Metabolism 46(3) (1997), 287-291.
15. B. Li, A. Mahmood and D. Lu, Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1 level after traumatic brain injury, Neurosurgery 65 (2009),179-186.
16. D. Lominadze, W.L. Dean, S.C. Tyagi and A.M. Roberts, Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease, Acta Physiol (Oxf) 198(1) (2009), 1-13.
17. D. Lu and A. Mahmood, Atorvastatin reduction of intracranial hematoma volume in rats subjected to controlled cortical impact, Journal of Neurosurgery 101 (2004), 822-825.
18. D. Lu and A. Mahmood, Atorvastatin reduction of intravascular trombosis, increase in cerebral microvascular potency and integrity and enhancement of spatial learning in rats, Journal of Neurosurgery 101 (2004), 813-821.
19. D. Lu, C. Qu, A. Goussev, H. Jiang, C. Lu, T. Schallert, A. Mahmood, J. Chen, Y. Li and M. Chopp, Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury, J Neurotrauma 24 (2007), 1132-1146.
20. T. Maeda, T. Kawane and N. Horiuchi, Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation, Endocrinology 144 (2003), 681-692.
21. A. Mahmood, A. Goussev and H.Kazmi, Long-term benefits after treatment of traumatic brain injury with simvastatin in rats, Neurosurgery 65 (2009), 187-192.
22. W.L. Maxwell, Ultrastructural evidence of axonal shearing as a result of lateral acceleration of the head in non-human primates, Acta Neuropathologica 86 (1993), 136-144.
23. M.J. McGirt, J.R. Lynch, A. Parra, H. Sheng, R.D. Pearlstein, D.T. Laskowitz, D.A. Pelligrino and D.S.Warner, Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage, Stroke 33(12) (2002), 2950-2956.
24. P. Miossec, F. Zkhiri, J. Paries and M.D. Dufilho, Effect of pravastatin on erythrocyte rheological and biochemical properties in poorly controlled Type 2 diabetic patients, Diabetic Medicine 16 (1999), 424-430.
25. S. Morikawa,W. Takabe, C. Mataki, T. Kanke, T. Itoh,Y.Wada, A. Izumi,Y. Saito, T. Hamakubo and T.Kodama, The effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC (Human umbilical vein endothelial cells), J Atheroscler Thromb 9 (2002), 178-183.
26. A.V. Muravyov,V.V.Yakusevich and L. Surovaya, The effect of simvastatin therapy on hemorheological profile in coronary heart disease (CHD) patients, Clin Hemorheol Microcirc 31 (2004), 251-256.
27. N. Nemeth, J. Soukup and M. Menzel, Local and systemic hemorheological effects of cerebral hyper and hypoperfusion in porcine model, Clin Hemorheol Microcirc 35 (2006), 59-65.
28. S. QU Cheng, D. Lu and A. Goussev, Effect of atorvastatin on spatial memory, neuronal survival and vascular density in female rats after traumatic brain injury, Journal of Neurosurgery 103 (2005), 695-701.
29. B.Y. Salazar Vázquez, J. Martini, A. Chávez Negrete, A.G. Tsai, S. Forconi, P. Cabrales, P.C. Johnson and M. Intaglietta, Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence, Clin Hemorheol Microcirc 44(2) (2010), 75-85.
30. D. Seyfried, Y. Han and D. Lu, Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorage in rats, Journal of Neurosurgery 101 (2004), 104-107.
31. A.B. Singhal and M.A. Topcuoglu, SSRI and statin use increases the risk for vasospasm after subarachnoid hemorhage, Neurology 64(2) (2005), 1008-1013.
32. S. Trompet, P. Vliet, A.J. M. Craen, J. Jolles and B.M. Buckley, Pravastatin and cognitive function in the elderly. Results of the PROSPER study, J Neurol 257(1) (2009), 85-90.
33. O.F. Turkoglu, H. Eroglu, O. Okutan, M.K. Tun, E. Bodur, M.F. Sargon, L. Oner and E. Beskonakli, A comparative study of treatment for brain edema: Magnesium sulphate versus dexamethasone sodium phosphate, Journal of Clinical Neuroscience 15 (2008), 60-65.
34. O.F. Turkoglu, H. Eroglu, O. Okutan and O. Gurcan, Atorvastatin efficiency after traumatic brain injury in rats, Surgical Neurology 72 (2009), 146-152.
35. R. Vaz, A. Sarlnento, N. Borges and C. Cruz, Ultrastructural study of brain microvessels in patients with traumatic cerebral contusion, Acta Neurochir (Wien) 139 (1997), 215-220.
36. R. Vaz, A. Sarlnento, N. Borges, C. Cruz and T. Azevedo, Experimental traumatic cerebral contusion: Morphological study of brain microvessels and characterization of the edema, Acta Neurochir (Wien) 140 (1998), 76-81.
37. A.S. Wierzbiki, P.J. Lumb and Y.K. Semra, Effect of atorvastatin on plasma fibrinogen, The Lancet 351 (1998), 569-570.
38. F. Zhou and Z. Xiang, The expression and changes of heat shock protein 70, MDA and hemorheology in rat cortex after DIA with secondary insults, Journal of Clinical Neuroscience 8(3) (2001), 250-252.