Peptidyl arginine deiminase: A novel immunohistochemical marker for liver fibrosis in patients with chronic hepatitis

Acta Histochemica

Volumn 112, Issue 6, 2010, Pages 592-603

  Abdeen, Suad M ^a   Olusi, Samuel O ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Fibrosis scores; Hepatitis; METAVIR activity; Peptidylarginine deiminase

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN ARGININE DEIMINASE;

ADULT; ANTIBODY LABELING; ARTICLE; CHRONIC HEPATITIS; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNODETECTION; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CELL; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; SCORING SYSTEM;

ADULT; BIOLOGICAL MARKERS; FEMALE; HEPATITIS, CHRONIC; HUMANS; HYDROLASES; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; MALE; MIDDLE AGED;

EID: 77957166894     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2009.06.007     Document Type: Article

References (59)

1. Abdeen SM, Olusi SO, Askar HA, Thalib L, Al-Azemi A, George S. The predictive value of CD38 positive hepatic stellate cell count for assessing disease activity and fibrosis in patients with chronic hepatitis. Acta Histochem, in press, doi:10.1016/j.acthis.2008.04.008.
2. Albanis E., Friedman S.L. Hepatic fibrosis: pathogenesis and principles of therapy. Clin Liver Dis 2001, 5:315-334. v-vi.
3. Asaga H., Yamada M., Senshu T. Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem Biophys Res Commun 1998, 243:641-646.
4. Bataller R., North K.E., Bernner D.A. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology 2003, 37:493-503.
5. Bedossa P., Poynard T. An algorithm for the grading of activity in chronic hepatitis. The METAVIR Cooperative Study Group. Hepatology 1996, 24:289-293.
6. Beniac D.R., Wood D.D., Palaniyar N., Ottensmeyer F.P., Moscarello M.A., Harauz G. Cryoelectron microscopy of protein-lipid complexes of human myelin basic protein charge isomers differing in degree of citrullination. J Struct Biol 2000, 129:80-95.
7. Boggs J.M., Rangaraj G., Koshy K.M., Ackerley C., Wood D.D., Moscarello M.A. Highly deiminated isoform of myelin basic protein from multiple sclerosis brain causes fragmentation of lipid vesicles. J Neurosci Res 1999, 57:529-535.
8. Bombardieri M., Alessandri C., Labbadia G., Ianuccelli C., Carlucci F., Riccieri V., et al. Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement. Arthritis Res Ther 2004, 6:R137-R141.
9. Cao L., Goodin R., Wood D., Moscarello M.A., Whitaker J.N. Rapid release and unusual stability of immunodominant peptide 45-89 from citrullinated myelin basic protein. Biochemistry 1999, 38:6157-6163.
10. Caponi L., Petit-Teixeira E., Sebbag M., Bongiorni F., Moscato S., Pratesi F., et al. ECRAF: a family based study shows no association between rheumatoid arthritis and the PAD14 gene in a white French population. Ann Rheum Dis 2005, 64:587-593.
11. Carloni V., Pinzani M., Giusti S., Romanelli R.G., Parola M., Bellomo G., et al. Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells. Hepatology 2000, 31:131-140.
12. Chang X., Yamada R., Suzuki A., Sawada T., Yoshino S., Tokuhiro S., et al. Localization of peptidylarginine deiminase 4 (PAD14) and citrullinated protein in synovial tissue of rheumatoid arthritis. Rheumatology (Oxford) 2005, 44(1):40-50.
13. Chang X., Han J. Expression of peptidylarginine deiminase Type 4 (PAD 4) in various tumors. Mol Carcinogenesis 2006, 45:183-196.
14. Chang X., Han J., Pang L., Zhao Y., Yang Y., Shen Z. Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer 2009, 9:40.
15. Chavanas S., Mechin M.C., Takahara H., Kawada A., Nachat R., Serre G., et al. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PAD 16. Gene 2004, 330:19-27.
16. Cuthbert G.L., Daujat S., Snowden A.W., Snowden A.W., Erdjument-Bromage H., Hagiwara T., et al. Histone deimination antagonizes arginine methylation. Cell 2004, 1118:545-553.
17. Efsen E., Bonacchi A., Pastacaldi S., Valente A.J., Wenzel U.O., Tosti Guerra C., et al. Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells. Hepatology 2001, 337:713-721.
18. Feldmann M., Brennan F.M., Maini R.N. Rheumatoid arthritis. Cell 1996, 85:307-310.
19. Friedman S.L. Liver fibrosis - from bench to bedside. J Hepatol. 2003, 38(Suppl.1):S38-S53.
20. Friedman S.L. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis: mechanisms and treatment strategies. N Engl J Med 1993, 328:1828-1835.
21. Gokhan S., Marin H.M., Yung S.Y., Fontanez D., Casaccia B.P., Mehler M.F. Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression. J Neurosci 2005, 25:8311-8321.
22. Guerrin M., Ishigami A., Mechin M.C., Nachat R., Valmary S., Sebbag M., et al. cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I. Biochem J 2003, 370:167-174.
23. Hellerbrand, Wang S.C., Tsukamoto H., Brenner D.A., Rippe R.A. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology 1996, 24:670-676.
24. Horder M., Rej R. Alanine transaminase. Methods of enzymatic analysis 1983, Verlag-Chemie, Weinheim. 3rd ed. H.U. Bergmeyer, J. Bergmeyer, M. Grassl (Eds.).
25. Ishida Y.A., Senshu T., Takahashi H., Akiyama K., Nomura K., Lizuka H. Decreased deiminated keratin K1 in psoriatic hyperproliferative epidermis. J Invest Dermatol 2000, 114:701-705.
26. Ishida Y.A., Senshu T., Eady R.A., Takahashi H., Shimizu H., Akiyama M., et al. Sequential reorganization of cornified cell keratin filaments involving filaggrin-mediated compaction and keratin 1 deimination. J Invest Dermatol 2002, 118:282-287.
27. Ishigami A., Ohsawa T., Asaga H., Akiyama K., Kuramoto M., Maruyama N. Human peptidylarginine deiminase type II. Molecular cloning, gene organization and expression in human skin. Arch Biochem Biophys 2002, 407:25-31.
28. Kanno T., Kawada A., Yamanouchi J., Yoshida N.C., Yoshiki A., Shiraiwa M., et al. Human peptidylarginine deiminase type III. Molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme and immunohistochemical localization in human skin. J Invest Dermatol 2000, 115:813-823.
29. Kroot E.J., Jong B.A., Leeuwen M.A., Swinkels H., Hoogen F.H., Vant H.M., et al. The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent onset rheumatoid arthritis. Arthritis Rheum 2000, 43:1831-1835.
30. Mageed R.A. The RF antigen. Manual of biological markers of disease 1996, 1-27. Kluwer Academic Publishers, Dordrecht, The Netherlands, [Section B 1.1]. W.J. Van Venrooij, R.N. Maini (Eds.).
31. Marra F., Arrighi M.C., Fazi M., Caligiuri A., Pinzani M., Romanelli R.G., et al. Extracellular signal regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology 1999, 30:951-958.
32. Masson-Bessiere C., Sebbag M., Girbal-Neuhauser E., Nogueira L., Vincent C., Senshu T., et al. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha and beta chains of fibrin. J Immunol 2001, 166:4177-4184.
33. Masson-Bessiere C., Sebbag M., Durieux J.J., Nogueira L., Vincent C., Girbal-Neuhauser E., et al. In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher propotion of IgG than in synovial fluid and serum. Clin Exp Immunol 2000, 119:544-552.
34. Meyer O., Labarre C., Dougados M., Goupille P., Cantagrel A., Dubois A., et al. Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis to predicting five year radiographic damage. Ann Rheum Dis 2003, 62:120-126.
35. Mizoguchi M., Manabe M., Kawamura Y., Kondo Y., Ishidoh K., Kominami E., et al. Deimination of 70-kD nuclear protein during epidermal apoptotic events in vitro. J Histochem Cytochem 1998, 46:1303-1309.
36. Moscarello M.A., Wood D.D., Ackerley C., Boulias C. Myelin in multiple sclerosis is developmentally immature. J Clin Invest 1994, 94:146-154.
37. Nakashima K., Hagiwara T., Ishigami A., Nagata S., Asaga H., Kuramoto M., et al. Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1 alpha, 25-dihydroxyvitamin D(3). J Biol Chem 1999, 274:27786-27792.
38. Nijenhuis S., Zendman A.J., Vossenaar E.R., Pruijin G.J., Venrooij W.J. Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific marker. Clin Chim Acta 2004, 350:17-34.
39. Pinzani M., Marra F., Carloni V. Signal transduction in hepatic stellate cells. Liver 1998, 18:2-13.
40. Pritzker L.B., Joshi S., Gowan J.J., Harauz G., Moscarello M.A. Deimination of myelin basic protein 1. Effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D. Biochemistry 2000, 39:5374-5381.
41. Regev A., Molina E., Moua R., Bejarano P., Khaled A., Ruiz P., et al. Relaiability of histopathologic assessment for differentiation of recurrent hepatitis C from acute rejection after liver transplantation. Liver Transplantation 2004, 10:1233-1239.
42. Rej R., Horder M. Aspartate aminotransferase. Methods of enzymatic analysis 1983, 416-433. Verlag-Chemie, Weinheim. 3rd ed. H.U. Bergmeyer, J. Bergmeyer, M. Grassl (Eds.).
43. Reparon-Schuijt C.C., Van Esch W.J., Breedveld F.C., Verweij C.L. Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis. Arthritis Rheum 2001, 44:41-47.
44. Scholze A., Gotz B., Faissner A. Glial cell interactions with tenascin-C: adhesion and repulsion to different tenascin-C domains is cell type related. Int J Dev Neurosci 1996, 14:315-329.
45. Senshu T., Akiyama K., Ishigami A., Nomura K. Studies on specificity of peptidylarginine deiminase reactions using an immunochemical probe that recognizes an enzymatically deiminated partial sequence of mouse keratin K1. J Dewrmatol Sci 1999, 21:113-126.
46. Smeets T.J., Vossenaar E.R., Kraan M.C., Van Mansum W.A.M., Raats J.M., van Venrooij W.J., et al. Expression of citrulline-containing antigens in RA synovium. Arthritis Res 2002, 3:P4. (Abstr.).
47. Tarcsa E., Marekov L.N., Meri G., Melino G., Lee S.C., Steinert P.M. Protein unfolding by peptidylarginine deiminase: substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin. J Biol Chem 1996, 271:30709-30716.
48. Takahara H., Tsuchida M., Kusubata M., Akutsu K., Tagami S., Sugawara K. Peptidylarginine deiminase of the mouse: distribution, properties and immunocytochemical localization. J Biol Chem 1989, 264:13361-13368.
49. Urano Y., Watanabe K., Sakaki A., Arase S., Watanabe Y., Shigemi F., et al. Immmunohistochemical demonstration of peptidylarginine deiminase in human sweat glands. Am J Dermatopathol 1990, 12:249-255?.
50. Van Boekel M.A., Vossenaar E.R., Van den Hoogen fh., Van Venrooij W.J. Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res 2002, 4:87-93.
51. Venrooij W.J., Hazes J.M., Visser H. Anticitrullinated protein/peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis. Neth J Med 2002, 60:383-388.
52. Visser H., Cessie S., Vos K., Breedveld F.C., Hazes J.M. How to diagnose rheumatoid arthritis early? A prediction model for persistent (erosive) arthritis. Arthritis Rheum 2002, 46:357-365.
53. Vossenaar E.R., Despres N., Lapointe E., Heijden A., Lora M., Senshu T., et al. Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin. Arthritis Res Ther 2004, 6:R142-R150.
54. Vossenaar E.R., Nijenhuis S., Helsen M.M., Heijden A., Senshu T., Berg W.B., et al. Citrullination of synovial proteins in murine models of rheumatoid arthritis. Arthritis Rheum 2003, 48:2489-2500.
55. Wang Y., Wysocka J., Sayegh J., Sayegh J., Lee Y.H., Perlin J.R., et al. Human PAD4 regulates histone arginine methylation. Science 2004, 306:279-283.
56. Wood D.D., Bilbao J.M., O'Connors P., Moscarello M.A. Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein. Ann Neurol 1996, 40:18-24.
57. Wood D.D., Moscarello M.A. The isolation, characterization and lipid aggregating properties of a citrulline containing myelin basic protein. J Biol Chem 1989, 264:5121-5127.
58. Wright P.W., Bolling L.C., Calvert M.E., Sarmento O.F., Berkeley E.V., Shea M.C., et al. ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Dev Biol 2003, 256:73-88.
59. Zlobec I., Steele R., Michel R.P., Compton C.C., Compton C.C., Lugli A., et al. Scoring of P 53, VEGF BCl-2 and APAF-1 immunohistochemistry and inter observer reliability in colorectal cancer. Mod Pathol 2006, 19:1236-1242.