Dopamine D4 Receptors May Alleviate Antipsychotic-Induced Parkinsonism

Advances in Pharmacology

Volumn 42, Issue C, 1997, Pages 478-482

  Seeman, P ^a   Corbett, R ^b   Van Tol, H H M ^c  

^a UNIVERSITY OF TORONTO   (Canada)

^b SANOFI   (France)

^c CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77957161840     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60792-9     Document Type: Article

References (5)

1. Seeman P., Chau-Wong M., Tedesco J., and Wong K. Brain receptors for antipsychotic drugs and doparnine: Direct binding assays. Proc. Natl. Acad. Sci. U.S.A 72 (1975) 4376-4380
2. Meltzer H.Y. The role of serotonin in schizophrenia and the place of serotonin-dopamine antagonist antipsychotics. J. Clin. Psychopharmacol. 15 Suppl 1 (1995) 2S-3S
3. Seeman P., and Van Tol H.H.M. Deriving the therapeutic concentrations for clozapine and haloperidol: The apparent dissociation constant of a neuroleptic at the dopamine D 2 or D 4 receptor varies with the affinity of the competing radioligand. Eur. J. Pharmacol 291 (1995) 59-66
4. Seeman P., Corbett R., Nam D., and Van Tol H.H.M. Dopamine and serotonin receptors: Amino acid sequences, and clinical role in neuroleptic Parkinsonism. Jpn. J. Pharmacol 71 (1996) 187-204
5. Casey D. The nonhuman primate model: Focus on dopamine D2 and serotonin mechanisms. In: Fog R., Gerlach J., and Hemmingsen R. (Eds). Schizophrenia, Alfred Benson Symposium 28 (1995), Munksgaard, Copenhagen 287-297