Effects of dose, administration route, and/or vehicle on decabromodiphenyl ether concentrations in plasma of maternal, fetal, and neonatal rats and in milk of maternal rats

Drug Metabolism and Disposition

Volumn 38, Issue 10, 2010, Pages 1648-1654

  Biesemeier, John A ^a   Beck, Melissa J ^b   Silberberg, Hanna ^c   Myers, Nicole R ^b   Ariano, John M ^a   Bodle, Eric S ^b   Sved, Daniel W ^b   Jacobi, Sylvia ^d   Stump, Donald G ^b   Hardy, Marcia ^d   Stedeford, Todd ^d  

^a LANXESS DEUTSCHLAND GMBH   (Germany)

^b WIL RESEARCH LABORATORIES   (United States)

^c ICL IP America Inc   (United States)

^d Albemarle Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORN OIL; DECABROMODIPHENYL ETHER; FLAME RETARDANT; POLOXAMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BODY WEIGHT; BREAST MILK; CLINICAL EVALUATION; CONTROLLED STUDY; DOSE RESPONSE; EXPOSURE; FEEDING; FEMALE; FETUS BLOOD; FOOD INTAKE; LACTATION; MATERNAL PLASMA; MORBIDITY; MORTALITY; NEUROTOXICITY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; CORN OIL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL BLOOD; FLAME RETARDANTS; GESTATIONAL AGE; HALOGENATED DIPHENYL ETHERS; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; MILK; POLYETHYLENES; POLYPROPYLENES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS;

RATTUS; ZEA MAYS;

EID: 77957152791     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.033431     Document Type: Article

References (28)

1. Coffee ST (2008) Development and validation of a GC-ECD assay for the determination of decabromodiphenyl oxide (Debdpo) concentration in corn oil (Study No. WIL-635004), WIL Research Laboratories, LLC, Ashland, OH.
2. European Commission (2002) EUR 20402 EN - European Union risk assessment report bis(pentabromophenyl) ether, in 1st Priority List (Hansen BG, Munn SJ, de Bruijn J, Luotamo M, Pakalin S, Berthault F, Vegro S, Pellegrini G, Allanou R, and Scheer S eds) pp 1-282, Office for Official Publications of the European Communities, Luxembourg.
3. European Commission (2006) Commission Regulation (EC) No 565/2006 of 6 April 2006 imposing testing and information requirements on the importers or manufacturers of certain priority substances in accordance with Council Regulation (EEC) No 793/93 on the evaluation and control of the risks of existing substances. OJ L99:3-5.
4. el Dareer SM, Kalin JR, Tillery KF, and Hill DL (1987) Disposition of decabromobiphenyl ether in rats dosed intravenously or by feeding. J Toxicol Environ Health 22:405-415.
5. Hardy M, Banasik M, and Stedeford T (2009) Toxicology and human health assessment of decabromodiphenyl ether. Crit Rev Toxicol 39 (Suppl 3):1-44.
6. Hardy ML (2002) The toxicology of the three commercial polybrominated diphenyl oxide (ether) flame retardants. Chemosphere 46:757-777.
7. Hardy ML, Schroeder R, Biesemeier J, and Manor O (2002) Prenatal oral (gavage) developmental toxicity study of decabromodiphenyl oxide in rats. Int J Toxicol 21:83-91.
8. Huwe JK, Hakk H, Smith DJ, Diliberto JJ, Richardson V, Stapleton HM, and Birnbaum LS (2008) Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats. Environ Sci Technol 42:2694-2700.
9. Huwe JK and Smith DJ (2007) Accumulation, whole-body depletion, and debromination of decabromodiphenyl ether in male Sprague-Dawley rats following dietary exposure [published erratum appears in Environ Sci Technol 41: 4485, 2007]. Environ Sci Technol 41:2371-2377.
10. Kociba RJ, Frauson LO, Humiston CG, Norris JM, Wade CE, Lisowe RW, Quast JF, Jersey GC, and Jewett GL (1975) Results of a two-year dietary feeding study with decabromodiphenyl oxide (DBDPO) in rats. J Fire Flammability/Combustion Toxicol 2:267-285.
11. Morck A, Hakk H, Orn U, and Klasson Wehler E (2003) Decabromodiphenyl ether in the rat: absorption, distribution, metabolism, and excretion. Drug Metab Dispos 31:900-907.
12. Mörck A and Klasson-Wehler E (2001) Metabolism of decabromodiphenyl ether (BDE-209) in the rat, in Second International Workshop on Brominated Flame Retardants, pp 291-294, Stockholm University, Stockholm, Sweden.
13. Norris JM, Ehrmantraut JW, Gibbons CL, Kociba RJ, Schwetz BA, Rose JQ, Humiston CG, Jewett GL, Crummett WB, Gehring PJ, et al. (1973) Toxicological and environmental factors involved in the selection of decabromodiphenyl oxide as a fire retardant chemical. Appl Polym Symp 22:195-219.
14. Norris JM, Ehrmantraut JW, Gibbons CL, Kociba RJ, Schwetz BA, Rose JQ, Humiston CG, Jewett GL, Crummett WB, Gehring PJ, et al. (1974) Toxicological and environmental factors involved in the selection of decabromodiphenyl oxide as a fire retardant chemical. JFF/Combustion Toxicol 1:52-77.
15. Norris JM, Kociba RJ, Schwetz BA, Rose JQ, Humiston CG, Jewett GL, Gehring PJ, and Mailhes JB (1975) Toxicology of octabromobiphenyl and decabromodiphenyl oxide. Environ Health Perspect 11:153-161.
16. National Research Council (1996) Guide for the Care and Use of Laboratory Animals, 7th ed. National Academy Press, Washington, DC.
17. National Research Council (2000) Decabromodiphenyl oxide, in Toxicological Risks of Selected Flame-Retardant Chemicals, pp 72-98, National Academy Press, Washington, DC.
18. National Toxicology Program (1986) Toxicology and carcinogenesis studies of decabromodiphenyl oxide (CAS No. 1163-19-5) in F344/N rats and B6C3F1 mice (feed studies). Technical Report Series 309, pp 1-242.
19. O'Lear JR (2009) Development and validation of GC/MS assays for the determination of decabromodiphenyl oxide (DEBDPO) concentration in rat plasma and rat milk (Study No. WIL-635003), WIL Research Laboratories, LLC, Ashland, OH.
20. Organisation for Economic Co-operation and Development (1997) OECD Principles on good laboratory practice [C(97)186/Final], Organisation for Economic Co-operation and Development, Paris, France.
21. Organisation for Economic Co-operation and Development (2007) OECD guideline for the testing of chemicals. Developmental neurotoxicity study, pp 1-26, Organisation for Economic Co-operation and Development, Paris, France.
22. 14C]- decabromodiphenyl ether in pregnant Wistar rats. Environ Int 34:318-329.
23. Sandholm A, Emanuelsson BM, and Wehler EK (2003) Bioavailability and half-life of decabromodiphenyl ether (BDE-209) in rat. Xenobiotica 33:1149-1158. (Pubitemid 37500171)
24. van de Waterbeemd H and Testa B (2009) Introduction: the why and how of drug bioavailability research, in Drug Bioavailability - Estimation of Solubility, Permeability, Absorption and Bioavailability, 2nd, completely revised edition (van de Waterbeemd H and Testa B eds), pp 1-6, Wiley-VCH Verlag GmbH & Co., Weinheim, Germany.
25. Viberg H, Fredriksson A, Jakobsson E, Orn U, and Eriksson P (2001) Brominated flame retardant uptake, retention and developmental neurotoxic effects of decabromodiphenyl ether (PBDE 209) in the neonatal mouse, in Second International Workshop on Brominated Flame Retardants, pp 279-281, Stockholm University, Stockholm, Sweden.
26. Viberg H, Fredriksson A, Jakobsson E, Orn U, and Eriksson P (2003) Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain development. Toxicol Sci 76:112-120. (Pubitemid 37361890)
27. Zhou T, Ross DG, DeVito MJ, and Crofton KM (2001) Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol Sci 61:76-82. (Pubitemid 32409690)
28. Zoetis T and Walls I (2003) Principles and Practices for Direct Dosing of Pre-Weaning Mammals in Toxicity Testing and Research. A Report of the ILSI Risk Science Institute Expert Working Group, ILSI Press, Washington, DC.