메뉴 건너뛰기




Volumn 39, Issue SUPPL. 3, 2009, Pages 1-44

Toxicology and human health assessment of decabromodiphenyl ether BDE-209 human health assessment M. L. Hardy et al.

Author keywords

BDE 209; DBDPO; Decabromodiphenyl oxide; PBDE; PBDE 209; Polybrominated diphenyl ether; Reference dose

Indexed keywords

2,2',3,3',4,4',5,5',6,6' DECABROMODIPHENYL ETHER; DIPHENYL ETHER; UNCLASSIFIED DRUG;

EID: 70450183199     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408440903279946     Document Type: Review
Times cited : (46)

References (106)
  • 1
    • 70450121214 scopus 로고    scopus 로고
    • Quincy, MA, USA: National Fire Protection Association. Available at (accessed on February 2 2009)
    • Ahrens M (2008). Home Fires that Began with Upholstered Furniture. Quincy, MA, USA: National Fire Protection Association. Available at http://www. arfreprevention.org/pdf/Home-Fires-that-began-with-Upholstered-Furniture.pdf (accessed on February 2, 2009).
    • (2008) Home Fires That Began with Upholstered Furniture
    • Ahrens, M.1
  • 3
    • 72449169356 scopus 로고    scopus 로고
    • Developmental immunotoxicity and the importance of controlling for litter efects
    • DOI: 10.1016/j.etap.2009.08.003 (available at
    • Banasik M, Hardy M, Muro-Cacho C, Hover CG, Stedeford T (2009). Developmental immunotoxicity and the importance of controlling for litter efects. Environ Toxicol Pharmacol, DOI: 10.1016/j.etap.2009.08.003 (available at http://www.doi.org).
    • (2009) Environ Toxicol Pharmacol
    • Banasik, M.1    Hardy, M.2    Muro-Cacho, C.3    Hover, C.G.4    Stedeford, T.5
  • 4
    • 70450139634 scopus 로고    scopus 로고
    • Research integrity: A government perspective.
    • Birnbaum LS, Culpepper BT (1999). Research integrity: a government perspective. Prof Ethics 7:59-68.
    • (1999) Prof Ethics , vol.7 , pp. 59-68
    • Birnbaum, L.S.1    Culpepper, B.T.2
  • 5
    • 0018873844 scopus 로고
    • Induction of xenobiotic metabolism in rats by short-term administration of brominated diphenyl ethers.
    • Carlson GP (1980). Induction of xenobiotic metabolism in rats by short-term administration of brominated diphenyl ethers. Toxicol Lett 5:19-25.
    • (1980) Toxicol Lett , vol.5 , pp. 19-25
    • Carlson, G.P.1
  • 6
    • 70450164542 scopus 로고
    • CPTC Experiment Reference No. 78385-78392 Fairfeld, NJ, USA: Consumer Product Testing Company, Inc
    • CPTC (1978). A Dermal LD50 Study in Albino Rabbits and an Inhalation LD50 Study in Albino Rats. Experiment Reference No.: 78385-78392 Fairfeld, NJ, USA: Consumer Product Testing Company, Inc.
    • (1978) 50 Study in Albino Rats
  • 7
    • 55149101880 scopus 로고    scopus 로고
    • ECHA Chapter R.4: Evaluation of available information. Guidance for the implementation of REACH. European Chemicals Agency, 1-23. Available at accessed on February 2 2009
    • ECHA (2008) Guidance on Information Requirements and Chemical Safety Assessment. Chapter R.4: Evaluation of available information. Guidance for the implementation of REACH. European Chemicals Agency, 1-23. Available at http://guidance.echa.europa.eu/docs/guidance-document/information-requirements- r4-en.pdf?vers=20-08-08 (accessed on February 2, 2009).
    • (2008) Guidance on Information Requirements and Chemical Safety Assessment
  • 8
    • 0023608375 scopus 로고
    • Disposition of decabromobiphenyl ether in rats dosed intravenously or by feeding.
    • El Dareer SM, Kalin JR, Tillery KF, Hill DL (1987). Disposition of decabromobiphenyl ether in rats dosed intravenously or by feeding. J Toxicol Environ Health 22:405-415.
    • (1987) J Toxicol Environ Health , vol.22 , pp. 405-415
    • El Dareer, S.M.1    Kalin, J.R.2    Tillery, K.F.3    Hill, D.L.4
  • 9
    • 70450136333 scopus 로고
    • EPA From: Dan Barolo, Director, Ofce of Pesticide Programs; to: All Division Directors, Ofce of Pesticide Programs. Washington, DC, USA: Ofce of Prevention, Pesticides and Toxic Substances
    • EPA (1995). MEMORANDUM-Subject: Guidelines for study rejection based on GLP considerations. From: Dan Barolo, Director, Ofce of Pesticide Programs; to: All Division Directors, Ofce of Pesticide Programs. Washington, DC, USA: Ofce of Prevention, Pesticides and Toxic Substances.
    • (1995) MEMORANDUM-Subject: Guidelines for Study Rejection Based on GLP Considerations
  • 15
    • 70450144814 scopus 로고    scopus 로고
    • Benchmark Dose Technical Guidance Document.
    • EPA
    • EPA (2000). Benchmark Dose Technical Guidance Document. EPA/630/R-00/001.
    • (2000) EPA
  • 16
    • 70450156708 scopus 로고    scopus 로고
    • A Summary of General Assessment Factors for Evaluating the Quality of Scientifc and Technical Information.
    • EPA
    • EPA (2003). A Summary of General Assessment Factors for Evaluating the Quality of Scientifc and Technical Information. EPA 100/B-03/001.
    • (2003) EPA
  • 17
    • 70450123221 scopus 로고    scopus 로고
    • EPA Note: the panel Chair's name and comments were later removed in their entirety from the FINAL REPORT because of nondisclosure of conficts of interest. See: IRIS Toxicological Review and Summary Documents for Polybrominated Diphenyl Ethers (External Peer Review). Available at (updated document with panel Chair's name and comments removed) (accessed on February 2 2009)
    • EPA (2007a). External Peer Review, Toxicological Review for Polybrominated Diphenyl Ethers (PBDEs), Human Health Assessment, FINAL REPORT. Note: the panel Chair's name and comments were later removed in their entirety from the FINAL REPORT because of nondisclosure of conficts of interest. See: IRIS Toxicological Review and Summary Documents for Polybrominated Diphenyl Ethers (External Peer Review). Available at http://oaspub.epa.gov/eims/eimscomm. getfle?p-download-id=468479 (updated document with panel Chair's name and comments removed) (accessed on February 2, 2009).
    • (2007) External Peer Review, Toxicological Review for Polybrominated Diphenyl Ethers (PBDEs), Human Health Assessment, FINAL REPORT
  • 20
    • 70450121211 scopus 로고
    • EPA Good Laboratory Practice Standards. 40 Code of Federal Regulations FR Part 792
    • EPA (1989). Good Laboratory Practice Standards. 40 Code of Federal Regulations FR Part 792.
    • (1989)
  • 21
    • 70450130639 scopus 로고
    • Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry.
    • EPA
    • EPA (1994). Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry. EPA/600/8-90/066F.
    • (1994) EPA
  • 22
    • 70450142052 scopus 로고    scopus 로고
    • EPA Good Laboratory Practice Standards. 40 Code of Federal Regulations Part 160
    • EPA (1996). Good Laboratory Practice Standards. 40 Code of Federal Regulations Part 160.
    • (1996)
  • 24
    • 70450168023 scopus 로고    scopus 로고
    • A Review of the Reference Dose and Reference Concentration Processes.
    • EPA
    • EPA (2002). A Review of the Reference Dose and Reference Concentration Processes. EPA/630/P-02/002F.
    • (2002) EPA
  • 25
    • 70450164541 scopus 로고    scopus 로고
    • 3/4 as Default Method in Derivation of the Oral RfD.
    • EPA
    • EPA (2006). Harmonization in Interspecies Extrapolation: Use of BW3/4 as Default Method in Derivation of the Oral RfD. EPA/630/R-06/001.
    • (2006) EPA
  • 26
    • 84856170754 scopus 로고    scopus 로고
    • EPA. In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-07/008F
    • EPA (2008). Toxicological Review of Decabromodiphenyl Ether (BDE-209) (CAS No. 1163-19-5). In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-07/008F.
    • (2008) Toxicological Review of Decabromodiphenyl Ether (BDE-209) (CAS No. 1163-19-5)
  • 27
    • 33745588785 scopus 로고    scopus 로고
    • Developmental toxicology in the neonatal mouse: The use of randomly selected individuals as statistical unit compared to the litter in mice neonatally exposed to PBDE 99.
    • Abstract No. 1074
    • Eriksson P, von Rosen D, Viberg H, Fredriksson A (2005). Developmental toxicology in the neonatal mouse: the use of randomly selected individuals as statistical unit compared to the litter in mice neonatally exposed to PBDE 99. Toxicologist 84:219-220 (Abstract No. 1074).
    • (2005) Toxicologist , vol.84 , pp. 219-220
    • Eriksson, P.1    Von Rosen, D.2    Viberg, H.3    Fredriksson, A.4
  • 28
    • 33745613198 scopus 로고    scopus 로고
    • Tiered Testing in Mammals-Te Neonatal Animal Model
    • Hansson SO, Rudén C, eds. Stockholm, Sweden: US-AB Universitetsservice AB
    • Eriksson P, Viberg H (2005). 5. Tiered Testing in Mammals-Te Neonatal Animal Model. In: Hansson SO, Rudén C, eds. Science for a Safe Chemical Environment. Stockholm, Sweden: US-AB Universitetsservice AB, 103-133.
    • (2005) Science for A Safe Chemical Environment , vol.5 , pp. 103-133
    • Eriksson, P.1    Viberg, H.2
  • 29
    • 70450151122 scopus 로고    scopus 로고
    • Good Laboratory Practice for Nonclinical Laboratory Studies. 21 Code of Federal Regulations
    • FDA
    • FDA (2002). Good Laboratory Practice for Nonclinical Laboratory Studies. 21 Code of Federal Regulations. Part 58.
    • (2002) Part , vol.58
  • 30
    • 29544449097 scopus 로고    scopus 로고
    • Design and statistical methods in studies using animal models of development.
    • Festing MFW (2006). Design and statistical methods in studies using animal models of development. ILAR J 47:5-14.
    • (2006) ILAR J , vol.47 , pp. 5-14
    • Festing, M.F.W.1
  • 31
    • 38349121409 scopus 로고    scopus 로고
    • Co-exposure of neonatal mice to a fame retardant PBDE 99 (2,2′,4,4′,5-pentabromodiphenyl ether) and methyl mercury enhances developmental neurotoxic defects.
    • Fischer C, Fredriksson A, Eriksson P (2008). Co-exposure of neonatal mice to a fame retardant PBDE 99 (2,2′,4,4′,5-pentabromodiphenyl ether) and methyl mercury enhances developmental neurotoxic defects. Toxicol Sci 101:275-285.
    • (2008) Toxicol Sci , vol.101 , pp. 275-285
    • Fischer, C.1    Fredriksson, A.2    Eriksson, P.3
  • 32
    • 43349102568 scopus 로고    scopus 로고
    • Comment in author reply 411-413.
    • Comment in: Toxicol Sci (2008) 103:409-410, author reply 411-413.
    • (2008) Toxicol Sci , vol.103 , pp. 409-410
  • 33
    • 70450144000 scopus 로고    scopus 로고
    • FOAA Subject: RE: FOIA request for Individual Animal Data for Rice et al. Study. From: Andrew E. Smith; to: Marek Banasik; cc: Vincent Markowski, Nancy Bearsdley, Marina Tibeau, Deborah Rice, Paul Gauvreau. E-mail communication sent on August 15, 2007 at 6:01 PM (copy available on request)
    • FOAA (2007). Subject: RE: FOIA request for Individual Animal Data for Rice et al. Study. From: Andrew E. Smith; to: Marek Banasik; cc: Vincent Markowski, Nancy Bearsdley, Marina Tibeau, Deborah Rice, Paul Gauvreau. E-mail communication sent on August 15, 2007 at 6:01 PM (copy available on request).
    • (2007)
  • 34
    • 70450151121 scopus 로고    scopus 로고
    • FOIA. Washington, DC, USA: US Environmental Protection Agency. August 15, 2007 (copy available on request)
    • FOIA (2007). Freedom of Information Act Request: HQ-RIN-01639-07. Washington, DC, USA: US Environmental Protection Agency. August 15, 2007 (copy available on request).
    • (2007) Freedom of Information Act Request: HQ-RIN-01639-07
  • 35
    • 70450133411 scopus 로고    scopus 로고
    • FOIA December 19, 2008. Washington DC, USA; US Environmental Protection Agency (copy available on request)
    • FOIA (2008). Re: Freedom of Information Act Appeal HQ-RIN-00404-08-A [HQ-APP-00068-08]. December 19, 2008. Washington, DC, USA; US Environmental Protection Agency (copy available on request).
    • (2008) Re: Freedom of Information Act Appeal HQ-RIN-00404-08-A [HQ-APP-00068-08]
  • 36
    • 70450139635 scopus 로고    scopus 로고
    • Chlorinated and brominated contaminants and their metabolic/ degradation products: Bioaccumulation and distribution in East Greenland polar bears (Ursus maritimus) and ringed seals (Phoca hispida)
    • Oslo, Norway, August 21-25, 2006. Available at accessed on February 2 2009
    • Gebbink WA, Sonne C, Kirkegaard M, Riget FF, Born EW, Letcher RJ (2006). Chlorinated and brominated contaminants and their metabolic/ degradation products: bioaccumulation and distribution in East Greenland polar bears (Ursus maritimus) and ringed seals (Phoca hispida). Presented at Te 26th International Symposium on Halogenated Persistent Organic Pollutants-DIOXIN2006, Oslo, Norway, August 21-25, 2006. Available at http://www.dioxin2006.org (accessed on February 2, 2009
    • (2006) Presented at Te 26th International Symposium on Halogenated Persistent Organic Pollutants-DIOXIN2006
    • Gebbink, W.A.1    Sonne, C.2    Kirkegaard, M.3    Riget, F.F.4    Born, E.W.5    Letcher, R.J.6
  • 38
    • 0005732055 scopus 로고
    • Selection and use of the B6C3F1 mouse and F344 rat in long-term bioassays for carcinogenicity
    • Milman HA, Weisburger EK, eds. 2nd ed. Park Ridge, NJ, USA: Noyes Publications
    • Goodman DG, Boorman GA, Strandberg JD (1994). 17. Selection and use of the B6C3F1 mouse and F344 rat in long-term bioassays for carcinogenicity. In: Milman HA, Weisburger EK, eds. Handbook of Carcinogen Testing. 2nd ed. Park Ridge, NJ, USA: Noyes Publications, 347-390.
    • (1994) Handbook of Carcinogen Testing , vol.17 , pp. 347-390
    • Goodman, D.G.1    Boorman, G.A.2    Strandberg, J.D.3
  • 39
    • 67349225476 scopus 로고    scopus 로고
    • Neurodevelopmental efects of decabromodiphenyl ether (BDE-209) and implications for the reference dose.
    • Goodman JE (2009). Neurodevelopmental efects of decabromodiphenyl ether (BDE-209) and implications for the reference dose. Regul Toxicol Pharmacol 54:91-104.
    • (2009) Regul Toxicol Pharmacol , vol.54 , pp. 91-104
    • Goodman, J.E.1
  • 42
    • 70450139633 scopus 로고    scopus 로고
    • Deriving risks based on model parameters rather than experimental data (Toxicol Lett 179:6-14)
    • author reply 130-132
    • van der Ven et al (2008): Deriving risks based on model parameters rather than experimental data (Toxicol Lett 179:6-14). Toxicol Lett 182:127-129, author reply 130-132.
    • (2008) Toxicol Lett , vol.182 , Issue.127-129
    • Van Der Ven1
  • 43
    • 0036217881 scopus 로고    scopus 로고
    • Te toxicology of the three commercial polybrominated diphenyl oxide (ether) fame retardants.
    • Hardy ML (2002). Te toxicology of the three commercial polybrominated diphenyl oxide (ether) fame retardants. Chemosphere 46:757-777.
    • (2002) Chemosphere , vol.46 , pp. 757-777
    • Hardy, M.L.1
  • 44
    • 0035999622 scopus 로고    scopus 로고
    • Prenatal oral (gavage) developmental toxicity study of decabromodiphenyl oxide in rats.
    • Hardy ML, Schroeder R, Biesemeier J, Manor O (2002). Prenatal oral (gavage) developmental toxicity study of decabromodiphenyl oxide in rats. Int J Toxicol 21:83-91.
    • (2002) Int J Toxicol , vol.21 , pp. 83-91
    • Hardy, M.L.1    Schroeder, R.2    Biesemeier, J.3    Manor, O.4
  • 45
    • 0026730243 scopus 로고
    • Principles and pitfalls in the analysis of prenatal treatment efects in multiparous species.
    • Holson RR, Pearce B (1992). Principles and pitfalls in the analysis of prenatal treatment efects in multiparous species. Neurotoxicol Teratol 14:221-228.
    • (1992) Neurotoxicol Teratol , vol.14 , pp. 221-228
    • Holson, R.R.1    Pearce, B.2
  • 46
    • 45849115856 scopus 로고    scopus 로고
    • Statistical issues and techniques appropriate for developmental neurotoxicity testing: A report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints.
    • Holson RR, Freshwater L, Maurissen JPJ, Moser VC, Phang W (2008). Statistical issues and techniques appropriate for developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol Teratol 30:326-348.
    • (2008) Neurotoxicol Teratol , vol.30 , pp. 326-348
    • Holson, R.R.1    Freshwater, L.2    Maurissen, J.P.J.3    Moser, V.C.4    Phang, W.5
  • 47
    • 0024679058 scopus 로고
    • Occurrence and relevance of chemically induced benign neoplasms in long-term carcinogenicity studies.
    • Huf JE, Eustis SL, Haseman JK (1989). Occurrence and relevance of chemically induced benign neoplasms in long-term carcinogenicity studies. Cancer Metastasis Rev 8:1-21
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 1-21
    • Huf, J.E.1    Eustis, S.L.2    Haseman, J.K.3
  • 48
    • 34249973536 scopus 로고
    • Erratum in
    • Erratum in: Cancer Metastasis Rev (1989) 8:281.
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 281
  • 50
    • 34247110975 scopus 로고    scopus 로고
    • Accumulation whole-body depletion and debromination of decabromodiphenyl ether in male Sprague-Dawley rats following dietary exposure.
    • Huwe JK, Smith DJ (2007). Accumulation whole-body depletion and debromination of decabromodiphenyl ether in male Sprague-Dawley rats following dietary exposure. Environ Sci Technol 41:2371-2377.
    • (2007) Environ Sci Technol , vol.41 , pp. 2371-2377
    • Huwe, J.K.1    Smith, D.J.2
  • 51
    • 70450166587 scopus 로고    scopus 로고
    • Erratum in
    • Erratum in: Environ Sci Technol 41:4486.
    • Environ Sci Technol , vol.41 , pp. 4486
  • 52
    • 41649121354 scopus 로고    scopus 로고
    • Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats.
    • Huwe JK, Hakk H, Smith DJ, Diliberto JJ, Richardson V, Stapleton HM, Birnbaum LS (2008). Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats. Environ Sci Technol 42:2694-2700.
    • (2008) Environ Sci Technol , vol.42 , pp. 2694-2700
    • Huwe, J.K.1    Hakk, H.2    Smith, D.J.3    Diliberto, J.J.4    Richardson, V.5    Stapleton, H.M.6    Birnbaum, L.S.7
  • 54
    • 70450146812 scopus 로고
    • IBTL IBT No. 636-06545. Northbrook, IL, USA: Industrial Bio-Test Laboratories, Inc.
    • IBTL (1975). Human Repeated Insult Patch Test with DBDO-1 and XD8186.02. IBT No. 636-06545. Northbrook, IL, USA: Industrial Bio-Test Laboratories, Inc.
    • (1975) Human Repeated Insult Patch Test with DBDO-1 and XD8186.02.
  • 55
    • 56249084889 scopus 로고    scopus 로고
    • Neonatal exposure to deca-brominated diphenyl ether (PBDE 209) causes dose-response changes in spontaneous behaviour and cholinergic susceptibility in adult mice
    • Johansson N, Viberg H, Fredriksson A, Eriksson P (2008). Neonatal exposure to deca-brominated diphenyl ether (PBDE 209) causes dose-response changes in spontaneous behaviour and cholinergic susceptibility in adult mice. Neurotoxicology 29:911-919.
    • (2008) Neurotoxicology , vol.29 , pp. 911-919
    • Johansson, N.1    Viberg, H.2    Fredriksson, A.3    Eriksson, P.4
  • 57
    • 0029836939 scopus 로고    scopus 로고
    • 2,2′,4,5,5′-Pentachlorobiphenyl: Comparative metabolism in mink (Mustela vison) and mouse.
    • Klasson Wehler E, Hovander L, Lund B-O (1996). 2,2′,4,5,5′- Pentachlorobiphenyl: comparative metabolism in mink (Mustela vison) and mouse. Chem Res Toxicol 9:1340-1349.
    • (1996) Chem Res Toxicol , vol.9 , pp. 1340-1349
    • Klasson Wehler, E.1    Hovander, L.2    Lund, B.-O.3
  • 58
    • 0031080387 scopus 로고    scopus 로고
    • A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data.
    • Klimisch HJ, Andreae M, Tillmann U (1997). A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul Toxicol Pharmacol 25:1-5.
    • (1997) Regul Toxicol Pharmacol , vol.25 , pp. 1-5
    • Klimisch, H.J.1    Andreae, M.2    Tillmann, U.3
  • 62
    • 22344444174 scopus 로고    scopus 로고
    • Identifcation of hydroxylated polybrominated diphenyl ether metabolites in blood plasma from polybrominated diphenyl ether exposed rats.
    • Malmberg T, Athanasiadou M, Marsh G, Brandt I, Bergman A (2005). Identifcation of hydroxylated polybrominated diphenyl ether metabolites in blood plasma from polybrominated diphenyl ether exposed rats. Environ Sci Technol 39:5342-5348.
    • (2005) Environ Sci Technol , vol.39 , pp. 5342-5348
    • Malmberg, T.1    Athanasiadou, M.2    Marsh, G.3    Brandt, I.4    Bergman, A.5
  • 63
    • 0022456596 scopus 로고
    • National Toxicology Program nomenclature for hepatoproliferative lesions of rats.
    • Maronpot RR, Montgomery CA Jr, Boorman GA, McConnell EE (1986). National Toxicology Program nomenclature for hepatoproliferative lesions of rats. Toxicol Pathol 14:263-273.
    • (1986) Toxicol Pathol , vol.14 , pp. 263-273
    • Maronpot, R.R.1    Jr M.Ca2    Boorman, G.A.3    McConnell, E.E.4
  • 65
    • 84990745745 scopus 로고
    • Erratum in
    • Erratum in: Environ Mol Mutagen (1988) 12:345.
    • (1988) Environ Mol Mutagen , vol.12 , pp. 345
  • 66
    • 0038650993 scopus 로고    scopus 로고
    • Decabromodiphenyl ether in the rat: Absorption, distribution, metabolism, and excretion.
    • Mörck A, Hakk H, Örn U, Klasson Wehler E (2003). Decabromodiphenyl ether in the rat: absorption, distribution, metabolism, and excretion. Drug Metab Dispos 31:900-907.
    • (2003) Drug Metab Dispos , vol.31 , pp. 900-907
    • Mörck, A.1    Hakk, H.2    Örn, U.3    Klasson Wehler, E.4
  • 67
    • 20544446958 scopus 로고    scopus 로고
    • Direct dosing of preweaning rodents in toxicity testing and research: Deliberations of an ILSI RSI Expert Working Group.
    • Moser VC, Walls I, Zoetis T (2005). Direct dosing of preweaning rodents in toxicity testing and research: deliberations of an ILSI RSI Expert Working Group. Int J Toxicol 24:87-94.
    • (2005) Int J Toxicol , vol.24 , pp. 87-94
    • Moser, V.C.1    Walls, I.2    Zoetis, T.3
  • 72
    • 70450136331 scopus 로고    scopus 로고
    • Decabromodiphenyl oxide
    • NRC National Research Council. Washington, DC, USA: National Academy Press
    • NRC (2000). 5. Decabromodiphenyl oxide. In: Toxicological Risks of Selected Flame-Retardant Chemicals. National Research Council. Washington, DC, USA: National Academy Press, 72-98.
    • (2000) Toxicological Risks of Selected Flame-Retardant Chemicals , vol.5 , pp. 72-98
  • 73
    • 0003521206 scopus 로고
    • NTP Research Triangle Park, NC, USA: National Toxicology Program. Technical Report Series No.
    • NTP (1986). Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CAS No. 1163-19-5) in F344/N Rats and B6C3F1 Mice (Feed Studies). Research Triangle Park, NC, USA: National Toxicology Program. Technical Report Series No. 309.
    • (1986) 1 Mice (Feed Studies) , Issue.309
  • 74
    • 28144456644 scopus 로고    scopus 로고
    • NTP Research Triangle Park, NC, USA: National Toxicology Program. Available at accessed on February 2 2009
    • NTP (2005). 11th Report on Carcinogens-Factsheet. Research Triangle Park, NC, USA: National Toxicology Program. Available at http://ntp.niehs. nih.gov/index.cfm?objectid=C93A7BFD-F1F6-975E-79175836BE119887 (accessed on February 2(2009).
    • (2005) 11th Report on Carcinogens-Factsheet
  • 75
    • 0003479926 scopus 로고    scopus 로고
    • OECD Carcinogenicity Studies. Organization for Economic Co-operation and Development
    • OECD (1981a). OECD Guideline for the Testing of Chemicals. Carcinogenicity Studies. Organization for Economic Co-operation and Development. 451
    • (1981) OECD Guideline for the Testing of Chemicals , pp. 451
  • 77
    • 30944455810 scopus 로고    scopus 로고
    • OECD OECD Principles on Good Laboratory Practice (as revised in 1997). Organization for Economic Cooperation and Development. ENV/MC/CHEM(98)
    • OECD (1998). OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring. Number 1. OECD Principles on Good Laboratory Practice (as revised in 1997). Organization for Economic Cooperation and Development. ENV/MC/CHEM(98)17.
    • (1998) OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring. Number 1. , pp. 17
  • 79
    • 0003479926 scopus 로고    scopus 로고
    • OECD Developmental Neurotoxicity Study. Organization for Economic Co-operation and Development. OECD/OCDE
    • OECD (2007). OECD Guideline for the Testing of Chemicals. Developmental Neurotoxicity Study. Organization for Economic Co-operation and Development. OECD/OCDE 426.
    • (2007) OECD Guideline for the Testing of Chemicals , pp. 426
  • 80
    • 70450123220 scopus 로고    scopus 로고
    • OSHA 13 Carcinogens (4-Nitrobiphenyl, etc.) 29 Code of Federal Regulations Standard 1910.1003. Occupational Safety and Health Administration
    • OSHA (2008). 13 Carcinogens (4-Nitrobiphenyl, etc.). 29 Code of Federal Regulations Standard 1910.1003. Occupational Safety and Health Administration.
    • (2008)
  • 82
    • 34249311963 scopus 로고    scopus 로고
    • Developmental delays and locomotor activity in the C57BL6/J mouse following neonatal exposure to the fully-brominated PBDE, decabromodiphenyl ether.
    • Rice DC, Reeve EA, Herlihy A, Zoeller RT, Tompson WD, Markowski VP (2007). Developmental delays and locomotor activity in the C57BL6/J mouse following neonatal exposure to the fully-brominated PBDE, decabromodiphenyl ether. Neurotoxicol Teratol 29:511-520.
    • (2007) Neurotoxicol Teratol , vol.29 , pp. 511-520
    • Rice, D.C.1    Reeve, E.A.2    Herlihy, A.3    Zoeller, R.T.4    Tompson, W.D.5    Markowski, V.P.6
  • 84
    • 0345491348 scopus 로고    scopus 로고
    • Bioavailability and half-life of decabromodiphenyl ether (BDE-209) in rat
    • DOI 10.1080/00498250310001609156
    • Sandholm A, Emanuelsson B-M, Klasson Wehler E (2003). Bioavailability and half-life of decabromodiphenyl ether (BDE-209) in rat. Xenobiotica 33:1149-1158. (Pubitemid 37500171)
    • (2003) Xenobiotica , vol.33 , Issue.11 , pp. 1149-1158
    • Sandholm, A.1    Emanuelsson, B.-M.2    Klasson Wehler, E.3
  • 89
    • 7444220698 scopus 로고    scopus 로고
    • Absorption of decabromodiphenyl ether and other organohalogen chemicals by grey seals (Halichoerus grypus)
    • Tomas GO, Moss SEW, Asplund L, Hall AJ (2005). Absorption of decabromodiphenyl ether and other organohalogen chemicals by grey seals (Halichoerus grypus). Environ Pollut 133:581-586.
    • (2005) Environ Pollut , vol.133 , pp. 581-586
    • Tomas, G.O.1    Moss, S.E.W.2    Asplund, L.3    Hall, A.J.4
  • 90
    • 33745221453 scopus 로고    scopus 로고
    • Postnatal exposure of the male mouse to 2,2′,3,3′,4,4′, 5,5′,6,6′-decabrominated diphenyl ether: Decreased epididymal sperm functions without alterations in DNA content and histology in testis.
    • Tseng L-H, Lee C-W, Pan M-H, Tsai S-S, Li M-H, Chen J-R, Lay J-J, Hsu P-C (2006). Postnatal exposure of the male mouse to 2,2′,3,3′,4, 4′,5,5′,6,6′-decabrominated diphenyl ether: decreased epididymal sperm functions without alterations in DNA content and histology in testis. Toxicology 224:33-43.
    • (2006) Toxicology , vol.224 , pp. 33-43
    • Tseng, L.-H.1    Lee, C.-W.2    Pan, M.-H.3    Tsai, S.-S.4    Li, M.-H.5    Chen, J.-R.6    Lay, J.-J.7    Hsu, P.-C.8
  • 91
    • 36348955441 scopus 로고    scopus 로고
    • Developmental exposure to decabromodiphenyl ether (PBDE 209): Efects on thyroid hormone and hepatic enzyme activity in male mouse ofspring.
    • Tseng L-H, Li M-H, Tsai S-S, Lee C-W, Pan M-H, Yao W-J, Hsu P-C (2008). Developmental exposure to decabromodiphenyl ether (PBDE 209): efects on thyroid hormone and hepatic enzyme activity in male mouse ofspring. Chemosphere 70:640-647.
    • (2008) Chemosphere , vol.70 , pp. 640-647
    • Tseng, L.-H.1    Li, M.-H.2    Tsai, S.-S.3    Lee, C.-W.4    Pan, M.-H.5    Yao, W.-J.6    Hsu, P.-C.7
  • 93
    • 0242363211 scopus 로고    scopus 로고
    • Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defned period of neonatal brain development.
    • Viberg H, Fredriksson A, Jakobsson E, Örn U, Eriksson P (2003). Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defned period of neonatal brain development. Toxicol Sci 76:112-120.
    • (2003) Toxicol Sci , vol.76 , pp. 112-120
    • Viberg, H.1    Fredriksson, A.2    Jakobsson, E.3    Örn, U.4    Eriksson, P.5
  • 94
    • 2442716424 scopus 로고    scopus 로고
    • Comment in
    • Comment in: Toxicol Sci (2004) 79:205-206
    • (2004) Toxicol Sci , vol.79 , pp. 205-206
  • 95
    • 70450156707 scopus 로고    scopus 로고
    • author reply 207-208.
    • author reply 207-208.
  • 96
    • 16644368137 scopus 로고    scopus 로고
    • comment in
    • comment in: Toxicol Sci (2004) 81:528-529.
    • (2004) Toxicol Sci , vol.81 , pp. 528-529
  • 97
    • 33846597471 scopus 로고    scopus 로고
    • Changes in spontaneous behaviour and altered response to nicotine in the adult rat after neonatal exposure to the brominated fame retardant, decabrominated diphenyl ether (PBDE 209)
    • Viberg H, Fredriksson A, Eriksson P (2007). Changes in spontaneous behaviour and altered response to nicotine in the adult rat after neonatal exposure to the brominated fame retardant, decabrominated diphenyl ether (PBDE 209). Neurotoxicology 28:136-142.
    • (2007) Neurotoxicology , vol.28 , pp. 136-142
    • Viberg, H.1    Fredriksson, A.2    Eriksson, P.3
  • 98
    • 37849008239 scopus 로고    scopus 로고
    • Neonatal exposure to decabrominated diphenyl ether (PBDE 209) results in changes in BDNF, CaMKII and GAP-43, biochemical substrates of neuronal survival, growth, and synaptogenesis
    • Viberg H, Mundy W, Eriksson P (2008). Neonatal exposure to decabrominated diphenyl ether (PBDE 209) results in changes in BDNF, CaMKII and GAP-43, biochemical substrates of neuronal survival, growth, and synaptogenesis. Neurotoxicology 29:152-159.
    • (2008) Neurotoxicology , vol.29 , pp. 152-159
    • Viberg, H.1    Mundy, W.2    Eriksson, P.3
  • 100
    • 84883834089 scopus 로고    scopus 로고
    • Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defned period of neonatal brain development (Toxicol Sci 76:112-120)
    • Viberg et al. (2003): Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defned period of neonatal brain development (Toxicol Sci 76:112-120). Toxicol Sci 79:205-206.
    • (2003) Toxicol Sci , vol.79 , pp. 205-206
    • Viberg, E.1
  • 101
    • 70450155227 scopus 로고    scopus 로고
    • author reply: 207-208.
    • author reply: 207-208.
  • 102
    • 0025233496 scopus 로고
    • Induction of rat liver microsomal cytochrome P-450 by the pentabromo diphenyl ether Bromkal 70 and half-lives of its components in the adipose tissue
    • von Meyerinck L, Hufnagel B, Schmoldt A, Benthe HF (1990). Induction of rat liver microsomal cytochrome P-450 by the pentabromo diphenyl ether Bromkal 70 and half-lives of its components in the adipose tissue. Toxicology 61:259-274.
    • (1990) Toxicology , vol.61 , pp. 259-274
    • Von Meyerinck, L.1    Hufnagel, B.2    Schmoldt, A.3    Benthe, H.F.4
  • 104
    • 52949105118 scopus 로고    scopus 로고
    • Efects of decabrominated diphenyl ether (DBDE) on developmental immunotoxicity in ofspring mice
    • Watanabe W, Shimizu T, Kurokawa M (2008). Efects of decabrominated diphenyl ether (DBDE) on developmental immunotoxicity in ofspring mice. Environ Toxicol Pharmacol 26:315-319.
    • (2008) Environ Toxicol Pharmacol , vol.26 , pp. 315-319
    • Watanabe, W.1    Shimizu, T.2    Kurokawa, M.3
  • 105
    • 0035035416 scopus 로고    scopus 로고
    • Efects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats
    • Zhou T, Ross DG, DeVito MJ, Crofton KM (2001). Efects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol Sci 61:76-82.
    • (2001) Toxicol Sci , vol.61 , pp. 76-82
    • Zhou, T.1    Ross, D.G.2    Devito, M.J.3    Crofton, K.M.4
  • 106
    • 1042264685 scopus 로고    scopus 로고
    • Principles & Practices for Direct Dosing of Pre-Weaning Mammals in Toxicity Testing and Research
    • Washington, DC, USA: ILSI Press
    • Zoetis T, Walls I (2003). Principles & Practices for Direct Dosing of Pre-Weaning Mammals in Toxicity Testing and Research. A Report of the ILSI Risk Science Institute Expert Working Group. Washington, DC, USA: ILSI Press.
    • (2003) A Report of the ILSI Risk Science Institute Expert Working Group
    • Zoetis, T.1    Walls, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.