Growth hormone status predicts left ventricular mass in patients after cure of acromegaly

Growth Hormone and IGF Research

Volumn 20, Issue 5, 2010, Pages 333-337

  Wexler, Tamara L ^a   Durst, Ronen ^a   McCarty, David ^a   Picard, Michael H ^a   Gunnell, Lindsay ^a   Omer, Zehra ^a   Fazeli, Pouneh ^a   Miller, Karen K ^a   Klibanski, Anne ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Acromegaly; Growth hormone deficiency; Left ventricular mass

Indexed keywords

GROWTH HORMONE;

ACROMEGALY; ADULT; AGED; ARTICLE; BODY MASS; BODY SURFACE; CARDIOVASCULAR PARAMETERS; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLE; DOPPLER ECHOCARDIOGRAPHY; FEMALE; GROWTH HORMONE DEFICIENCY; HEART DISEASE; HEART EJECTION FRACTION; HEART FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HUMAN; MALE; PREDICTION; PRIORITY JOURNAL; REFERENCE VALUE; THREE DIMENSIONAL ECHOCARDIOGRAPHY;

ACROMEGALY; ADOLESCENT; ADULT; AGED; CROSS-SECTIONAL STUDIES; ECHOCARDIOGRAPHY; FEMALE; HEART VENTRICLES; HUMAN GROWTH HORMONE; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; ORGAN SIZE; STROKE VOLUME; YOUNG ADULT;

EID: 77957133689     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2010.05.003     Document Type: Article

References (46)

1. Rajasoorya C., Holdaway I.M., Wrightson P., Scott D.J., Ibbertson H.K. Determinants of clinical outcome and survival in acromegaly. Clin. Endocrinol. (Oxf) 1994, 41:95-102.
2. Holdaway I.M. Excess mortality in acromegaly. Horm. Res. 2007, 68(Suppl 5):166-172.
3. Swearingen B., Barker F.G., Katznelson L., et al. Long-term mortality after transsphenoidal surgery and adjunctive therapy for acromegaly. J. Clin. Endocrinol. Metab. 1998, 83:3419-3426.
4. Holdaway I.M., Rajasoorya R.C., Gamble G.D. Factors influencing mortality in acromegaly. J. Clin. Endocrinol. Metab. 2004, 89:667-674.
5. Clayton R.N. Cardiovascular function in acromegaly. Endocr. Rev. 2003, 24:272-277.
6. Smallridge R.C., Rajfer S., Davia J., Schaaf M. Acromegaly and the heart, an echocardiographic study. Am. J. Med. 1979, 66:22-27.
7. Rossi L., Thiene G., Caragaro L., Giordano R., Lauro S. Dysrhythmias and sudden death in acromegalic heart disease. A clinicopathologic study. Chest 1977, 72:495-498.
8. Lopez-Velasco R., Escobar-Morreale H.F., Vega B., et al. Cardiac involvement in acromegaly: specific myocardiopathy or consequence of systemic hypertension?. J. Clin. Endocrinol. Metab. 1997, 82:1047-1053.
9. Lombardi G., Galdiero M., Auriemma R.S., Pivonello R., Colao A. Acromegaly and the cardiovascular system. Neuroendocrinology 2006, 83:211-217.
10. Lombardi G., Colao A., Marzullo P., Biondi B., Palmieri E., Fazio S. Improvement of left ventricular hypertrophy and arrhythmias after lanreotide-induced GH and IGF-I decrease in acromegaly. A prospective multi-center study. J. Endocrinol. Invest. 2002, 25:971-976.
11. Colao A., Marzullo P., Di Somma C., Lombardi G. Growth hormone and the heart. Clin. Endocrinol. (Oxf) 2001, 54:137-154.
12. Fazio S., Cittadini A., Biondi B., et al. Cardiovascular effects of short-term growth hormone hypersecretion. J. Clin. Endocrinol. Metab. 2000, 85:179-182.
13. Frustaci Test A. Cell death in acromegalic cardiomyopathy. Circulation 1999, 99:1426-1434.
14. Ito H., Hirata Y., Adachi S., et al. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J. Clin. Invest. 1993, 92:398-403.
15. Minniti G., Jaffrain-Rea M.L., Moroni C., et al. Echocardiographic evidence for a direct effect of GH/IGF-I hypersecretion on cardiac mass and function in young acromegalics. Clin. Endocrinol. (Oxf) 1998, 49:101-106.
16. Pivonello R., Galderisi M., Auriemma R.S., et al. Treatment with growth hormone receptor antagonist in acromegaly: effect on cardiac structure and performance. J. Clin. Endocrinol. Metab. 2007, 92:476-482.
17. Maison P., Tropeano A.I., Macquin-Mavier I., Giustina A., Chanson P. Impact of somatostatin analogs on the heart in acromegaly: a metaanalysis. J. Clin. Endocrinol. Metab. 2007, 92:1743-1747.
18. Colao A., Pivonello R., Galderisi M., et al. Impact of treating acromegaly first with surgery or somatostatin analogs on cardiomyopathy. J. Clin. Endocrinol. Metab. 2008, 93:2639-2646.
19. De Marinis L., Bianchi A., Mazziotti G., et al. The long-term cardiovascular outcome of different GH-lowering treatments in acromegaly. Pituitary 2008, 11:13-20.
20. Rosen T., Bengtsson B.A. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990, 336:285-288.
21. Beauregard C., Utz A., Schaub A.E., et al. Growth hormone (GH) decreases visceral fat and improves cardiovascular risk (CV) markers in women with hypopituitarism: a randomized, placebo-controlled study. J. Clin. Endocrinol. Metab. 2008, 93:2063-2071.
22. Oliveira J.L., Aguiar-Oliveira M.H., D'Oliveira A., et al. Congenital growth hormone (GH) deficiency and atherosclerosis: effects of GH replacement in GH-naive adults. J. Clin. Endocrinol. Metab. 2007, 92:4664-4670.
23. Colao A., Di Somma C., Spiezia S., et al. The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis. J. Clin. Endocrinol. Metab. 2006, 91:2191-2200.
24. Cuneo R.C., Salomon F., McGauley G.A., Sonksen P.H. The growth hormone deficiency syndrome in adults. Clin. Endocrinol. (Oxf) 1992, 37:387-397.
25. De Boer H., Blok G.J., Voerman H.J., De Vries P.M., van der Veen E.A. Body composition in adult growth hormone-deficient men, assessed by anthropometry and bioimpedance analysis. J. Clin. Endocrinol. Metab. 1992, 75:833-837.
26. Binnerts A., Deurenberg P., Swart G.R., Wilson J.H., Lamberts S.W. Body composition in growth hormone-deficient adults. Am. J. Clin. Nutr. 1992, 55:918-923.
27. Weaver J.U., Monson J.P., Noonan K., et al. The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. J. Clin. Endocrinol. Metab. 1995, 8:153-159.
28. Gomez J.M., Sahun M., Vila R., et al. Peripheral fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function in hypopituitary adults with growth hormone deficiency. Clin. Endocrinol. (Oxf) 2006, 64:632-639.
29. Colao A., Di Somma C., Cuocolo A., et al. Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency. J. Clin. Endocrinol. Metab. 2005, 90:5146-5155.
30. Rosen T., Eden S., Larson G., Wilhelmsen L., Bengtsson B.A. Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinol. (Copenh) 1993, 129:195-200.
31. Barreto-Filho J.A., Alcantara M.R., Salvatori R., et al. Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia. J. Clin. Endocrinol. Metab. 2002, 87:2018-2023.
32. Cuneo R.C., Salomon F., Watts G.F., Hesp R., Sonksen P.H. Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metabolism 1993, 42:1519-1523.
33. Devin J.K., Blevins L.S., Verity D.K., et al. Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. J. Clin. Endocrinol. Metab. 2007, 92:3633-3639.
34. Shahi M., Beshyah S.A., Hackett D., Sharp P.S., Johnston D.G., Foale R.A. Myocardial dysfunction in treated adult hypopituitarism: a possible explanation for increased cardiovascular mortality. Br. Heart J. 1992, 67:92-96.
35. Longobardi S., Cuocolo A., Merola B., et al. Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency. Clin. Endocrinol. (Oxf) 1998, 48:137-143.
36. Colao A., di Somma C., Cuocolo A., et al. Improved cardiovascular risk factors and cardiac performance after 12months of growth hormone (GH) replacement in young adult patients with GH deficiency. J. Clin. Endocrinol. Metab. 2001, 86:1874-1881.
37. Merola B., Cittadini A., Colao A., et al. Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. J. Clin. Endocrinol. Metab. 1993, 77:1658-1661.
38. Valcavi R., Gaddi O., Zini M., Iavicoli M., Mellino U., Portioli I. Cardiac performance and mass in adults with hypopituitarism: effects of one year of growth hormone treatment. J. Clin. Endocrinol. Metab. 1995, 80:659-666.
39. Biller B.M., Samuels M.H., Zagar A., et al. Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J. Clin. Endocrinol. Metab. 2002, 87:2067-2079.
40. Hartman M.L., Crowe B.J., Biller B.M., Ho K.K., Clemmons D.R., Chipman J.J. Which patients do not require a GH stimulation test for the diagnosis of adult GH deficiency?. J. Clin. Endocrinol. Metab. 2002, 87:477-485.
41. Wexler T., Gunnell L., Omer Z., et al. Growth hormone deficiency is associated with decreased quality of life in patients with prior acromegaly. J. Clin. Endocrinol. Metab. 2009, 94:2471-2477.
42. Levy D., Savage D.D., Garrison R.J., Anderson K.M., Kannel W.B., Castelli W.P. Echocardiographic criteria for left ventricular hypertrophy: the Framingham Heart Study. Am. J. Cardiol. 1987, 59:956-960.
43. Devereux R.B., Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 1977, 55:613-618.
44. Nagueh S.F., Appleton C.P., Gillebert T.C., et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J. Am. Soc. Echocardiogr. 2009, 22:107-133.
45. Verma A., Meris A., Skali H., et al. Prognostic implications of left ventricular mass and geometry following myocardial infarction: the VALIANT (VALsartan In Acute myocardial iNfarcTion) Echocardiographic Study. JACC Cardiovasc. Imaging 2008, 1:582-591.
46. Colao A. A 2008 The GH/IGF axis and the cardiovascular system: clinical implications. Clin. Endocrinol. (Oxf) 2008, 69:347-358.