Development of effective protein delivery system to mucosa-associated lymphoid tissues (MALT) with M cell-targeting technology

Drug Delivery System

Volumn 23, Issue 5, 2008, Pages 529-533

  Nochi, Tomonori ^a   Kiyono, Hiroshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

M cells; mucosal immune system; mucosal vaccine

Indexed keywords

EID: 77957017342     PISSN: 09135006     EISSN: 18812732     Source Type: Journal    
DOI: 10.2745/dds.23.529     Document Type: Article

References (20)

1. Kiyono H, Kuniswa J, McGhee JR, Mestecky J:The mucosal immune system. Fundermental Immunology. (ed. Paul WE), Lippincott-Raven, Philadelphia, 2008 (in press).
2. Kunisawa J, Nochi T, Kiyono H:Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol, 2008 (in press).
3. Owen RL:Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine:an ultrastructural study. Gastroenterology 72:440-451, 1977.
4. Savidge TC, Smith MW, James PS, Aldred P:Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue. Am J Pathol 139:177-184, 1991.
5. Clark MA, Hirst BH, Jepson MA: M-cell surface beta1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer's patch M cells. Infect Immun 66:1237-1243, 1998.
6. Lugering A, Floer M, Westphal S, Maaser C, Spahn TW:Absence of CCR6 inhibits CD4+ regulatory T-cell development and M-cell formation inside Peyer's patches. Am J Pahol 166:1647-1654, 2005.
7. Yamamoto M, Rennert P, McGhee JR, Kweon MN, Yamamoto S et al.:Alternate mucosal immune system:Organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. J Immunol 164:5184-5191, 2000.
8. Jang MH, Kweon MN, Iwatani K, Yamamoto M, Terahara K et al.:Intestinal villous M cells:an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci USA 101:6110-6115, 2004.
9. Rescigno M, Urbano M, Valzasina B, Franocolini M, Rotta G et al.:Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2:361-367, 2001.
10. Niess JH, Brand S, Gu X, Landsman L, Jung S et al.:CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307:254-258, 2005.
11. Brayden DJ, Jepson MA, Baird AW:Keynote review:intestinal Peyer's patch M cells and oral vaccine targeting. Drug Discov Today 10:1145-1157, 2005.
12. Sharma R, Schumacher U, Adam E:Lectin histochemistry reveals the appearance of M-cells in Peyer's patches of SCID mice after syngeneic normal bone marrow transplantation. J Histochem Cytochem 46:143-148, 1998.
13. Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K et al.:Novel M-cell-specific carbohydrate-targeted vaccination is effective for the induction of antigen-specific immune responses. J Exp Med 204:2789-2796, 2007.
14. Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS et al.:Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol 180:7840-7846, 2008.
15. Helander A, Silvey KJ, Mantis NJ, Hutchings AB, Chandran K et al.:The viral 1 protein and glycoconjugates containing 2-3-lined sialic acid are involved in type 1 reovirus adherence to M cell apical surface. J virol 77:7964-7977, 2003.
16. Higgins LM, Lambkin I, Donnelly G, Byrne D, Wilson C et al.:In vivo phage display to identify M cell-targeting ligands. Pharm Res 21:695-705, 2004.
17. Wang X, Kochetkova I, Haddad A, Hoyt T, Hone DM et al.:Transgene vaccination using Ulex europaeus agglutinin I (UEA-1) for targeted mucosal immunization against HIV envelop. Vaccine 23:3836-3842, 2005.
18. Manocha M, Pal PC, Chitalekha KT, Thomas BE, Tripathi V et al.:Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex Europaeus-I lection as M cell target. Vaccine 23:5599-5617, 2005.
19. Wang X, Hone DM, Haddad A, Shata MT, Pascual DW:M cell DNA vaccination for CTL immunity to HIV. J Immunol 171:4717-4725, 2003.
20. Suzuki H, Sekine S, Kataoka K, Pascual DW, Maddaloni M et al.:Ovaalbumin-protein 1 M cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells. Gastroenterology, 2008 (in press).