The influence of IgG density and macrophage Fc (gamma) receptor cross-linking on phagocytosis and IL-10 production

Immunology Letters

Volumn 133, Issue 2, 2010, Pages 70-77

  Gallo, Paul ^a   Gonçalves, Ricardo ^a   Mosser, David M ^a  

^a Bldg 142   (United States)

Author keywords

IL 10; Immune complexes; Inflammation; Macrophages; Phagocytosis

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 12; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BONE MARROW; COMPLEMENT SYSTEM; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE; FLOW CYTOMETRY; IMMUNOGLOBULIN DEPOSITION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN INDUCTION; SHEEP; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODY AFFINITY; CELLS, CULTURED; FEEDBACK, PHYSIOLOGICAL; IMMUNOGLOBULIN G; INTERLEUKIN-10; INTERLEUKIN-12; MACROPHAGES; MICE; MICE, INBRED BALB C; PHAGOCYTOSIS; PROTEIN BINDING; RECEPTOR AGGREGATION; RECEPTORS, IGG; SIGNAL TRANSDUCTION;

EID: 77957016117     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2010.07.004     Document Type: Article

References (42)

1. Nimmerjahn F., Ravetch J.V. Fcgamma receptors: old friends and new family members. Immunity 2006, 24(January):19-28.
2. Nimmerjahn F., Bruhns P., Horiuchi K., Ravetch J.V. FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity 2005, 23(July):41-51.
3. Indik Z., Park J., Hunter S., Schreiber A. The molecular dissection of Fc gamma receptor mediated phagocytosis. Blood 1995, 86(December):4389-4399.
4. Nimmerjahn F., Ravetch J.V. Fc-receptors as regulators of immunity. Adv Immunol 2007, 96:179-204.
5. Sondermann P., Oosthuizen V. X-ray crystallographic studies of IgG-Fc gamma receptor interactions. Biochem Soc Trans 2002, 30(August):481-486.
6. Indik Z.K., Hunter S., Huang M.M., Pan X.Q., Chien P., Kelly C., et al. The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI. Exp Hematol 1994, 22(July):599-606.
7. Isakov N. Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades. J Leukoc Biol 1997, 61(January):6-16.
8. Crowley M.T., Costello P.S., Fitzer-Attas C.J., Turner M., Meng F., Lowell C., et al. A critical role for Syk in signal transduction and phagocytosis mediated by Fc{gamma} receptors on macrophages. J Exp Med 1997, 186(October):1027-1039.
9. Cox D., Greenberg S. Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system. Semin Immunol 2001, 13(December):339-345.
10. Barrionuevo P., Beigier-Bompadre M., Fernandez G.C., Gomez S., Alves-Rosa M.F., Palermo M.S., et al. Immune complex-FcγR interaction modulates monocyte/macrophage molecules involved in inflammation and immune response. Clin Exp Immunol 2003, 133(August):200-207.
11. Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008, 8(December):958-969.
12. Fukata M., Vamadevan A.S., Abreu M.T. Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders. Semin Immunol 2009, 21(August):242-253.
13. Swanson J.A., Hoppe A.D. The coordination of signaling during Fc receptor-mediated phagocytosis. J Leukoc Biol 2004, 76(December):1093-1103.
14. Rönnelid J., Ahlin E., Nilsson B., Nilsson-Ekdahl K., Mathsson L. Immune complex-mediated cytokine production is regulated by classical complement activation both in vivo and in vitro. Adv Exp Med Biol 2008, 632:187-201.
15. Sutterwala F.S., Noel G.J., Clynes R., Mosser D.M. Selective suppression of interleukin-12 induction after macrophage receptor ligation. J Exp Med 1997, 185(June):1977-1985.
16. Sutterwala F.S., Noel G.J., Salgame P., Mosser D.M. Reversal of proinflammatory responses by ligating the macrophage Fc{gamma} receptor type I. J Exp Med 1998, 188(July):217-222.
17. Syed S.N., Konrad S., Wiege K., Nieswandt B., Nimmerjahn F., Schmidt R.E., et al. Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a. Eur J Immunol 2009, 39(December):3343-3356.
18. Fronhofer V., Lennartz M.R., Loegering D.J. Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages. J Leukoc Biol 2006, 79(February):408-415.
19. Lucas M., Zhang X., Prasanna V., Mosser D.M. ERK activation following macrophage FcgammaR ligation leads to chromatin modifications at the IL-10 locus. J Immunol 2005, 175(July):469-477.
20. Edwards J.P., Zhang X., Frauwirth K.A., Mosser D.M. Biochemical and functional characterization of three activated macrophage populations. J Leukoc Biol 2006, 80(December):1298-1307.
21. Anderson C.F., Mosser D.M. Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors. J Immunol 2002, 168(April):3697-3701.
22. Gerber J.S., Mosser D.M. Reversing lipopolysaccharide toxicity by ligating the macrophage Fc gamma receptors. J Immunol 2001, 166(June):6861-6868.
23. Mosser D.M., Zhang X. Interleukin-10: new perspectives on an old cytokine. Immunol Rev 2008, 226(December):205-218.
24. Weissmann G. Rheumatoid arthritis and systemic lupus erythematosus as immune complex diseases. Bull NYU Hosp Jt Dis 2009, 67:251-253.
25. Mayadas T.N., Tsokos G.C., Tsuboi N. Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation 2009, 120(November):2012-2024.
26. Refici M.L., Metzger D.W., Arulanandam B.P., Lennartz M.R., Loegering D.J. Fcgamma-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-alpha levels. Am J Physiol Regul Integr Comp Physiol 2001, 280(April):R1037-R1044.
27. Miles S.A., Conrad S.M., Alves R.G., Jeronimo S.M.B., Mosser D.M. A role for IgG immune complexes during infection with the intracellular pathogen Leishmania. J Exp Med 2005, 201(March):747-754.
28. Deo Y.M., Graziano R.F., Repp R., van de Winkel J.G. Clinical significance of IgG Fc receptors and Fc gamma R-directed immunotherapies. Immunol Today 1997, 18(March):127-135.
29. Wenink M.H., Santegoets K.C.M., Roelofs M.F., Huijbens R., Koenen H.J.P.M., van Beek R., et al. The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease. J Immunol 2009, 183(October):4509-4520.
30. Mullazehi M., Mathsson L., Lampa J., Rönnelid J. Surface-bound anti-type II collagen-containing immune complexes induce production of tumor necrosis factor alpha, interleukin-1beta, and interleukin-8 from peripheral blood monocytes via Fc gamma receptor IIA: a potential pathophysiologic mechanism for humoral anti-type II collagen immunity in arthritis. Arthritis Rheum 2006, 54(June):1759-1771.
31. Laborde E.A., Vanzulli S., Beigier-Bompadre M., Isturiz M.A., Ruggiero R.A., Fourcade M.G., et al. Immune complexes inhibit differentiation, maturation, and function of human monocyte-derived dendritic cells. J Immunol 2007, 179(July):673-681.
32. Anderson C.F., Lucas M., Gutierrez-Kobeh L., Field A.E., Mosser D.M. T cell biasing by activated dendritic cells. J Immunol 2004, 173(July):955-961.
33. Durand V., Pers J.O., Renaudineau Y., Youinou P., Jamin C. Soluble Fcgamma receptor IIIb alters the function of polymorphonuclear neutrophils but extends their survival. Eur J Immunol 2001, 31(July):1952-1961.
34. Ragab A., Bodin S., Viala C., Chap H., Payrastre B., Ragab-Thomas J. The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking. J Biol Chem 2003, 278(October):40923-40932.
35. Dale B.M., Traum D., Erdjument-Bromage H., Tempst P., Greenberg S. Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding. J Immunol 2009, 182(May):5654-5662.
36. Kanmert D., Enocsson H., Wetterö J., Kastbom A., Skogh T., Enander K. Designed surface with tunable IgG density as an in vitro model for immune complex mediated stimulation of leukocytes. Langmuir 2010, 26(March):3493-3497.
37. Saraiva M., O'Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol 2010, 10(March):170-181.
38. Krupa A., Fudala R., Stankowska D., Loyd T., Allen T.C., Matthay M.A., et al. Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors. Am J Respir Cell Mol Biol 2009, 41(August):155-169.
39. Ballow M. Mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory diseases. J Allergy Clin Immunol 1997, 100(August):151-157.
40. Nimmerjahn F., Ravetch J.V. The antiinflammatory activity of IgG: the intravenous IgG paradox. J Exp Med 2007, 204(January):11-15.
41. Gosselin E.J., Bitsaktsis C., Li Y., Iglesias B.V. Fc receptor-targeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and non-mucosal pathogens. Arch Immunol Ther Exp (Warsz) 2009, 57(October):311-323.
42. Pleass R.J. Fc-receptors and immunity to malaria: from models to vaccines. Parasite Immunol 2009, 31(September):529-538.