Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant

Cell Cycle

Volumn 9, Issue 18, 2010, Pages 3754-3763

  Bellomaria, A ^a   Barbato, Gaetano ^a   Melino, G ^a,b   Paci, M ^a   Melino, Sonia ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Cell death; E3 ubiquitin ligases; Ectodermal dysplasia; HECT; Itch; p53 family; p63; Rapp hodgkin syndrome

Indexed keywords

PROLINE RICH PROTEIN; PROTEIN P 36; PROTEIN P63; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AEC SYNDROME; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CIRCULAR DICHROISM; ECTODERMAL DYSPLASIA; FLUORESCENCE; HUMAN; HUNTINGTON CHOREA; MUSCULAR DYSTROPHY; MUTANT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; PRURITUS; RAPP HODGKIN SYNDROME; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ANALYSIS; WELLS SYNDROME;

ISLA VISTA VIRUS;

EID: 77957006621     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.18.12933     Document Type: Article

References (43)

1. Bernassola F, Karin M, Ciechanover A, Melino G. The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell 2008; 14:16-8.
2. Eldridge AG, O'Brien T. Therapeutic strategies within the ubiquitin proteasome system. Cell Death Differ 17:4-13.
3. Rossi M, De Laurenzi V, Munarriz E, Green DR, Liu YC, Vousden KH, et al. The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 2005; 24:836-48.
4. Oberst A, Malatesta M, Aqeilan RI, Rossi M, Salomoni P, Murillas R, et al. The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. Proc Natl Acad Sci USA 2007; 104:11280-5.
5. Rossi M, Aqeilan RI, Neale M, Candi E, Salomoni P, Knight RA, et al. The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci USA 2006; 103:12753-8.
6. Rossi M, De Simone M, Pollice A, Santoro R, La Mantia G, Guerrini L, et al. Itch/AIP4 associates with and promotes p63 protein degradation. Cell Cycle 2006; 5:1816-22.
7. Bakkers J, Camacho-Carvajal M, Nowak M, Kramer C, Danger B, Hammerschmidt M. Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation and its implications on dorsoventral patterning of the zebrafish embryo. Cell Cycle 2005; 4:790-800.
8. Li Y, Zhou Z, Chen C. WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis. Cell Death Differ 2008; 15:1941-51.
9. Ianakiev P, Kilpatrick MW, Toudjarska I, Basel D, Beighton P, Tsipouras P. Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27. Am J Hum Genet 2000; 67:59-66. (Pubitemid 30481544)
10. McGrath JA, Duijf PH, Doetsch V, Irvine AD, de Waal R, Vanmolkot KR, et al. Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. Hum Mol Genet 2001; 10:221-9.
11. Amiel J, Bougeard G, Francannet C, Raclin V, Munnich A, Lyonnet S, et al. TP63 gene mutation in ADULT syndrome. Eur J Hum Genet 2001; 9:642-5. (Pubitemid 32776382)
12. van Bokhoven H, Hamel BC, Bamshad M, Sangiorgi E, Gurrieri F, Duijf PH, et al. p63 Gene mutations in eec syndrome, limb-mammary syndrome and isolated split hand-split foot malformation suggest a genotype-phenotype correlation. Am J Hum Genet 2001; 69:481-92.
13. van Bokhoven H, McKeon F. Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans. Trends Mol Med 2002; 8:133-9. (Pubitemid 34532639)
14. Kantaputra PN, Hamada T, Kumchai T, McGrath JA. Heterozygous mutation in the SAM domain of p63 underlies Rapp-Hodgkin ectodermal dysplasia. J Dent Res 2003; 82:433-7. (Pubitemid 41766007)
15. Bougeard G, Hadj-Rabia S, Faivre L, Sarafan-Vasseur N, Frebourg T. The Rapp-Hodgkin syndrome results from mutations of the TP63 gene. Eur J Hum Genet 2003; 11:700-4. (Pubitemid 37160992)
16. Candi E, Dinsdale D, Rufini A, Salomoni P, Knight RA, Mueller M, et al. TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle 2007; 6:274-85.
17. McKeon F, Melino G. Fog of war: the emerging p53 family. Cell Cycle 2007; 6:229-32.
18. Crum CP, McKeon FD. p63 in epithelial survival, germ cell surveillance and neoplasia. Annu Rev Pathol 5:349-71.
19. Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee CC, et al. DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res 2003; 63:2351-7.
20. Macias MJ, Wiesner S, Sudol M. WW and SH3 domains, two different scaffolds to recognize prolinerich ligands. FEBS Lett 2002; 513:30-7.
21. Sudol M, Hunter T. NeW wrinkles for an old domain. Cell 2000; 103:1001-4.
22. Zarrinpar A, Lim WA. Converging on proline: the mechanism of WW domain peptide recognition. Nat Struct Biol 2000; 7:611-3.
23. Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, et al. WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol 2005; 25:7092-106.
24. Ilsley JL, Sudol M, Winder SJ. The WW domain: linking cell signalling to the membrane cytoskeleton. Cell Signal 2002; 14:183-9.
25. Bertola DR, Kim CA, Albano LM, Scheffer H, Meijer R, van Bokhoven H. Molecular evidence that AEC syndrome and Rapp-Hodgkin syndrome are variable expression of a single genetic disorder. Clin Genet 2004; 66:79-80.
26. Venyaminov SY, Yang JT. Determination of protein secondary structure. In: Fasman GD, Ed. Circular Dichroism and the Conformational Analysis of Biomolecules. New York: Plenum Press 1996; 69-107.
27. Rabanal F, Ludevid MD, Pons M, Giralt E. CD of proline-rich polypeptides: application to the study of the repetitive domain of maize glutelin-2. Biopolymers 1993; 33:1019-28.
28. Blanch EW, Morozova-Roche LA, Cochran DA, Doig AJ, Hecht L, Barron LD. Is polyproline II helix the killer conformation? A Raman optical activity study of the amyloidogenic prefibrillar intermediate of human lysozyme. J Mol Biol 2000; 301:553-63.
29. Uversky VN. Natively unfolded proteins: a point where biology waits for physics. Protein Sci 2002; 11:739-56.
30. Creamer TP, Campbell MN. Determinants of the polyproline II helix from modeling studies. Adv Protein Chem 2002; 62:263-82.
31. Shi Z, Woody RW, Kallenbach NR. Is polyproline II a major backbone conformation in unfolded proteins? Adv Protein Chem 2002; 62:163-240.
32. Buck M. Trifluoroethanol and colleagues: cosolvents come of age. Recent studies with peptides and proteins. Q Rev Biophys 1998; 31:297-355.
33. Woody RW, Sugeta H, Kodama TS. Circular dichroism of proteins: recent developments in analysis and prediction. Tanpakushitsu Kakusan Koso 1996; 41:56-69.
34. Qin H, Pu HX, Li M, Ahmed S, Song J. Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration. Biochemistry 2008; 47:13647-58.
35. Koepf EK, Petrassi HM, Ratnaswamy G, Huff ME, Sudol M, Kelly JW. Characterization of the structure and function of W → F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding. Biochemistry 1999; 38:14338-51.
36. Finkelstein AV, Ptitsyn OB. Soft condensed matter complex fluids and Biomaterials series. in Protein Physics. Lecture 5. London: Academic Press 2002; 51.
37. Chong PA, Lin H, Wrana JL, Forman-Kay JD. An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. J Biol Chem 2006; 281:17069-75.
38. Prontera P, Escande F, Cocchi G, Donti E, Martini A, Sensi A. An intermediate phenotype between Hay- Wells and Rapp-Hodgkin syndromes in a patient with a novel P63 mutation: confirmation of a variable phenotypic spectrum with a common aetiology. Genet Couns 2008; 19:397-402.
39. Cicero DO, Falconi M, Candi E, Mele S, Cadot B, Di Venere A, et al. NMR structure of the p63 SAM domain and dynamical properties of G534V and T537P pathological mutants, identified in the AEC syndrome. Cell Biochem Biophys 2006; 44:475-89.
40. Aurora R, Rose GD. Helix capping. Protein Sci 1998; 7:21-38.
41. Karplus PA. Hydrophobicity regained. Protein Sci 1997; 6:1302-7.
42. Marley J, Lu M, Bracken C. A method for efficient isotopic labeling of recombinant proteins. J Biomol NMR 2001; 20:71-5. (Pubitemid 32519656)
43. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, Bax A. NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 1995; 6:277-93.