Cobinamide is superior to other treatments in a mouse model of cyanide poisoning

Clinical Toxicology

Volumn 48, Issue 7, 2010, Pages 709-717

  Chan, Adriano ^a   Balasubramanian, Maheswari ^a   Blackledge, William ^a   Mohammad, Othman M ^a   Alvarez, Luis ^a   Boss, Gerry R ^a   Bigby, Timothy D ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Antidote; Hydroxocobalamin; Poisoning; Poisoning management

Indexed keywords

ANTIDOTE; COBALAMIN; COBINAMIDE; COBINAMIDE SULFITE; CYANIDE; HYDROXOCOBALAMIN; SODIUM NITRITE; SODIUM THIOSULFATE; UNCLASSIFIED DRUG; COBAMAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA; ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; CONTROLLED STUDY; CYANIDE POISONING; DRUG EFFICACY; DRUG SOLUBILITY; INHALATION; MALE; METABOLISM; MOUSE; NONHUMAN; PRECURSOR; TISSUE DISTRIBUTION; ANIMAL; C57BL MOUSE; DOSE RESPONSE; INHALATIONAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; LD 50;

ANIMALIA; MUS;

ADMINISTRATION, INHALATION; ANIMALS; ANTIDOTES; COBAMIDES; CYANIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROXOCOBALAMIN; INJECTIONS, INTRAMUSCULAR; LETHAL DOSE 50; MALE; MICE; MICE, INBRED C57BL;

EID: 77957003291     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2010.505197     Document Type: Article

References (35)

1. Scheffler IE. Mitochondria make a come back. Adv Drug Deliv Rev 2001; 49(1-2):3-26.
2. Salkowski AA, Penney DG. Cyanide poisoning in animals and humans: a review. Vet Hum Toxicol 1994; 36(5):455-466.
3. Way JL. Cyanide intoxication and its mechanism of antagonism. Annu Rev Pharmacol Toxicol 1984; 24:451-481.
4. Baskin SI, Brewer TG. Chapter 10: Cyanide poisoning. In: Zajtchuk R, Bellamy RF, eds. Medical Aspects of Chemical and Biological Warfare. Washington, DC: Office of The Surgeon General, Borden Institute, Walter Reed Army Medical Center; 1997.
5. Suskind R. The One Percent Doctrine: Deep Inside Americas Pursuit of Its Enemies Since 9/11. New York, NY: Simon & Schuster; 2006.
6. Alcorta R. Smoke inhalation & acute cyanide poisoning. Hydrogen cyanide poisoning proves increasingly common in smoke-inhalation victims. Jems 2004; 29(8):Suppl 6-15; quiz Suppl 6-7.
7. Alarie Y. Toxicity of fire smoke. Crit Rev Toxicol 2002; 32(4):259-289.
8. Silverman SH, Purdue GF, Hunt JL, Bost RO. Cyanide toxicity in burned patients. J Trauma 1988;28(2): 171-176.
9. Broderick KE, Potluri P, Zhuang S, Scheffler IE, Sharma VS, Pilz RB, Boss GR. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood) 2006; 231(5):641-649.
10. Brenner M, Mahon SB, Lee J, Kim J, Mukai D, Goodman S, Kreuter KA, Ahdout R, Mohammad O, Sharma VS, Blackledge W, Boss GR. Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy monitoring. J Biomed Opt 2010; 15(1):017001.
11. Brenner M, Kim JG, Mahon SB, Lee J, Kreuter KA, Blackledge W, Mukai D, Patterson S, Mohammad O, Sharma VS, Boss GR. Intramuscular cobinamide sulfite in a Rabbit model of sublethal cyanide toxicity. Ann Emerg Med 2009; 55: 352-363.
12. Renz P. Some intermediates in the biosynthesis of vitamin B12. Method Enzymol 1971; 18(Part 3):82-92.
13. Guilbault GG, Kramer DN. Ultra sensitive, specific method for cyanide using p-nitrobenzaldehyde and o-dinitrobenzene. Anal Chem 1966; 38(7):834-836.
14. Lundquist P, Rosling H, Sorbo B. Determination of cyanide in whole blood, erythrocytes, and plasma. Clin Chem 1985; 31(4):591-595.
15. Gewitz HS, Pistorius EK, Voss H, Vennesland B. Cyanide formation in preparations from Chlorella rulgaris Beijerinck: effect of sonication and amygdalin addition. Planta (Berl) 1976; 131:145-148.
16. Boxer GE, Rickards JC. Determination of thiocyanate in body fluids. Arch Biochem Biophys 1952; 39:292-300.
17. Bruce RD. An up-and-down procedure for acute toxicity testing. Fundam Appl Toxicol 1985; 5(1):151-157.
18. Esposito FM, Alarie Y. Inhalation toxicity of carbon monoxide and hydrogen cyanide gases released during the thermal decomposition of polymers. J Fire Sci 1988; 6:195-242.
19. Doi M, Ikeda K. Postanesthetic respiratory depression in humans: a comparison of sevoflurane, isoflurane and halothane. J Anesth 1987; 1(2):137-142.
20. Moore SJ, Ho IK, Hume AS. Severe hypoxia produced by concomitant intoxication with sublethal doses of carbon monoxide and cyanide. Toxicol Appl Pharmacol 1991; 109(3):412-420.
21. Broderick KE, Singh V, Zhuang S, Kambo A, Chen JC, Sharma VS, Pilz RB, Boss GR. Nitric oxide scavenging by the cobalamin precursor cobinamide. J Biol Chem 2005; 280(10):8678-8685.
22. Sharma VS, Pilz RB, Boss GR, Magde D. Reactions of nitric oxide with vitamin B12 and its precursor, cobinamide. Biochemistry 2003; 42(29):8900-8908.
23. Dolphin D. B12. New York, NY: Wiley-Interscience; 1981. Guidance on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals. M3 (R2). 2008; 15 July 2008. http://www.fda.gov/downloads/RegulatoryInformation/Guidances/ucm129524.pdf. Accessed 26 March 2010.
24. Gracia R, Shepherd G. Cyanide poisoning and its treatment. Pharmacotherapy 2004; 24(10):1358-1365.
25. Hayward GC, Hill HA, Pratt JM, Vanston NJ, Williams RJ. The chemistry of vitamin B12. IV. The thermodynamic trans-effect. J Chem Soc [Perkin 1] 1965; September:6485-6493.
26. Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, VS, Pilz RB, Bigby TD, Boss GR. Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J Infect Dis 2008; 197(3):457-464.
27. Broderick KE, Balasubramanian M, Chan A, Potluri P, Feala J, Belke DD, McCulloch A, Sharma VS, Pilz RB, Bigby TD, Boss GR. The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide. Exp Biol Med (Maywood) 2007; 232(6):789-798.
28. Evans CL. Cobalt compounds as antidotes for hydrocyanic acid. Br J Pharmacol Chemother 1964; 23:455-475.
29. Matijak-Schaper M, Alarie Y. Toxicity of carbon monoxide, hydrogen cyanide and low oxygen. J Combust Toxicol 1982; 9:21.
30. Gentry RT, Rappaport MS, Dole VP. Serial determination of plasma ethanol concentrations in mice. Physiol Behav 1983; 31(4):529-532.
31. Borron SW, Baud FJ, Barriot P, Imbert M, Bismuth C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg Med 2007; 49(6):794-801, e1-2.
32. Norris JC, Moore SJ, Hume AS. Synergistic lethality induced by the combination of carbon monoxide and cyanide. Toxicology 1986; 40(2):121-129.
33. OPRR/ARENA IACUC Guidebook. 2002. 26 March 2009. http://grants.nih.gov/ grants/olaw/olaw.htm. Accessed 26 March 2010.
34. United States Public Health Service Policy on Humane Care and Use of Laboratory Animals, 2002. . http://grants.nih.gov/grants/olaw/references/ phspol.htm. Accessed 26 March 2010.
35. NIH CounterACT Program: Countermeasures Against Chemical Threats. 2009. http://www.ninds.nih.gov/research/counterterrorism/ counterACT-home.htm. Accessed 26 March 2010.