Vitamin C And cancer: What can we conclude - 1,609 patients and 33 years later?

Puerto Rico Health Sciences Journal

Volumn 29, Issue 3, 2010, Pages 215-217

  Cabanillas, Fernando ^a,b,c  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Auxilio Mutuo Hospital   (Puerto Rico)

Author keywords

Cancer; Dose; Plasma level; Vitamin C

Indexed keywords

ASCORBIC ACID; VITAMIN;

HUMAN; NEOPLASM; REVIEW; TIME;

ASCORBIC ACID; HUMANS; NEOPLASMS; TIME FACTORS; VITAMINS;

EID: 77956995087     PISSN: 07380658     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (12)

1. Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A 1976;73: 3685-3689.
2. DeWys W. How to evaluate a new treatment for cancer. Your Patient and Cancer 1982;2: 31-36.
3. Creagan ET, Moertel CG, O'Fallon JR, et al. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med 1979;301: 687-690.
4. Moertel CG, Fleming TR, Creagan ET, Rubin J, O'Connell MJ, Ames MM. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med 1985;312: 137-141.
5. Tschetter. A community based study of vitamin C (ascorbic acid) in patients with advanced cancer. Proc ASCO 1983;2: abstr 92.
6. Robinson AB, Hunsberger A, Westall FC. Suppression of squamous cell carcinoma in hairless mice by dietary nutrient variation. Mech Ageing Dev 1994;76: 201-214.
7. Casciari JJ, Riordan NH, Schmidt TL, Meng XL, Jackson JA, Riordan HD. Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours. Br J Cancer 2001;84: 1544-1550.
8. Hoffer LJ, Levine M, Assouline S, et al. Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Ann Oncol 2008;19: 1969-1974.
9. Casciari JJ, Riordan HD, Miranda-Massari JR, Gonzalez MJ. Effects of high dose ascorbate administration on L-10 tumor growth in guinea pigs. P R Health Sci J 2005;24: 145-150.
10. Riordan HD, Casciari JJ, Gonzalez MJ, et al. A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients. P R Health Sci J 2005;24: 269-276.
11. McAllister CJ, Scowden EB, Dewberry FL, Richman A. Renal failure secondary to massive infusion of vitamin C. JAMA 1984;252: 1684.
12. Wong K, Thomson C, Bailey RR, McDiarmid S, Gardner J. Acute oxalate nephropathy after a massive intravenous dose of vitamin C. Aust N Z J Med 1994;24: 410-411.