RAGE and Aβ immunoglobulins: Relation to Alzheimers disease-related cognitive function

Journal of the International Neuropsychological Society

Volumn 16, Issue 4, 2010, Pages 672-678

  Mitchell, Meghan B ^a   Buccafusco, Jerry J ^b,c   Schade, Rosann F ^b,c   Webster, Scott J ^b   Mruthinti, Shyamala ^b,c   Harrell, Dean U ^b   Gulati, Nidhi K ^b   Miller, L Stephen ^a  

^a University of Georgia   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Biomarkers; Blood test; Dementia; Early detection; Immune system function; Memory function

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE FRAGMENT; RAGE PROTEIN, HUMAN; TUMOR ANTIGEN;

AGED; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; COGNITIVE DEFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOLOGY; MALE; METHODOLOGY; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGICAL RATING SCALE; STATISTICS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANTIGENS, NEOPLASM; COGNITION DISORDERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPSYCHOLOGICAL TESTS; PEPTIDE FRAGMENTS; PSYCHIATRIC STATUS RATING SCALES; STATISTICS AS TOPIC;

EID: 77956991398     PISSN: 13556177     EISSN: 14697661     Source Type: Journal    
DOI: 10.1017/S1355617710000469     Document Type: Article

References (14)

1. Alzheimer's Association. (2008). Alzheimer's disease facts and figures. Alzheimer's and Dementia, 4, 2.
2. Berg, L., McKeel, D. W., Miller, P., Storandt, M., Rubin, E., Morris, J. C., et al. (1998). Clinicopathologic studies in cognitively healthy aging and Alzheimer disease. Archives of Neurology, 55, 326-335.
3. Burke, W. J., Miller, J. P., Rubin, E. H., Morris, J. C., Coben, L. A., Duchek, J., et al. (1988). Reliability of the Washington University Clinical Dementia Rating. Archives of Neurology, 45, 31-32. (Pubitemid 18018582)
4. De Kosky, S. (2003). Early intervention is key to successful management of Alzheimer disease. Alzheimer Disease and Associated Disorders, 17, S99-S104.
5. Emanuele, E., D'Angelo, A., Tomaino, C., Binetti, G., Ghidoni, R., Politi, P., et al. (2005). Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia. Archives of Neurology, 62, 1734-1736. (Pubitemid 41626671)
6. McCulla, M. M., Coats, M., Van Fleet, N., Duchek, J., Grant, E., & Morris, J. C. (1989). Reliability of clinical nurse specialists in the staging of dementia. Archives of Neurology, 46, 1210-1211. (Pubitemid 19268390)
7. Morris, J. C. (1993). The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology, 43, 2412-2414.
8. Mruthinti, S., Buccafusco, J. J., Hill, W. D., Waller, J. L., Jackson, T. W., Zamrini, E. Y., & Schade, R. F. (2004). Autoimmunity in Alzheimer's disease: Increased levels of circulating IgGs binding Aβ and RAGE peptides. Neurobiology of Aging, 25, 1023-1032. (Pubitemid 38798064)
9. Mruthinti, S., Schade, R. F., Harrell, D. U., Gulati, N. K., Swamy-Mruthinti, S., Lee, G. P., & Buccafusco, J. J. (2006). Autoimmunity in Alzheimer's disease as evidenced by plasma immunoreactivity against RAGE and Aβ42: Complication of diabetes. Current Alzheimer Research, 3, 229-235. (Pubitemid 43988136)
10. Nath, A., Hall, E., Tuzova, M., Dobbs, M., Jones, M., Anderson, C., et al. (2003). Autoantibodies to amyloid β-peptide (Aβ) are increased in Alzheimer's disease patients and Aβ antibodies can enhance Aβ neurotoxicity. Neuro Molecular Medicine, 3, 29-39.
11. Neeper, M., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y. C., et al. (1992). Cloning and expression of cell surface receptor for advanced glycosylation end products of proteins. Journal of Biological Chemistry, 267, 4998-5004.
12. Randolph, C. (1998). Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). San Antonio, TX: The Psychological Corporation.
13. Randolph, C., Tierney, M., Mohr, E., & Chase, T. (1998). The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Preliminary clinical validity. Journal of Clinical and Experimental Neuropsychology, 20, 310-319. (Pubitemid 28539551)
14. Wilson, J. S., Mruthinti, S., Buccafusco, J. J., Schade, R. F., Mitchell, M. B., Harrell, D. U., et al. (2009). Anti-RAGE and Aβ immunoglobulin levels are related to dementia level and cognitive performance. Journals of Gerontology: Medical Sciences, 64 A, 264-271.