Overall synthesis of GSK356278: Quick delivery of a PDE4 inhibitor using a fit-for-purpose approach

Organic Process Research and Development

Volumn 14, Issue 5, 2010, Pages 1153-1161

  Guercio, Giuseppe ^a   Castoldi, Damiano ^a   Giubellina, Nicola ^a   Lamonica, Alessandro ^a   Ribecai, Arianna ^a   Stabile, Paolo ^a   Westerduin, Pieter ^a   Dams, Riet ^a   Nicoletti, Anna ^a   Rossi, Sara ^a   Bismara, Claudio ^a   Provera, Stefano ^a   Turco, Lucilla ^a  

^a GSK   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL TECHNIQUES; CARDIAC MYOCYTES; CHEMICAL SYNTHESIS; CYCLIC NUCLEOTIDE; GASTROINTESTINAL TRACT; IMMUNE CELLS; LOW-YIELD; MEDICINAL CHEMISTRY; OPTIMISATIONS; PDE4 INHIBITOR; PHOSPHODIESTERASES; RESEARCH AND DEVELOPMENT; SECOND MESSENGER; SIGNALING PATHWAYS; SYNTHETIC ROUTES;

CATALYSTS; ENZYMES; FETAL MONITORING; NUCLEOTIDES; SYNTHESIS (CHEMICAL);

ENZYME INHIBITION;

EID: 77956937824     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op1001148     Document Type: Article

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