Molecular determinants of the interactions between SRC-1 and LXR/RXR heterodimers

FEBS Letters

Volumn 584, Issue 18, 2010, Pages 3862-3866

  Son, You Lee ^a   Lee, Young Chul ^a  

^a Chonnam National University   (South Korea)

Author keywords

Heterodimer; Liver X receptor; NR box; Retinoid X receptor; Steroid receptor coactivator 1

Indexed keywords

CELL NUCLEUS RECEPTOR; LIVER X RECEPTOR; RETINOID X RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; ORPHAN NUCLEAR RECEPTOR;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; BINDING COMPETITION; CELL LINE; COMPARATIVE STUDY; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION; TWO HYBRID SYSTEM;

BINDING, COMPETITIVE; CELL LINE; HUMANS; NUCLEAR RECEPTOR COACTIVATOR 1; ORPHAN NUCLEAR RECEPTORS; PROTEIN MULTIMERIZATION; RETINOID X RECEPTORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 77956935644     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.07.056     Document Type: Article

References (11)

1. Peet D.J., Janowski B.A., Mangelsdorf D.J. The LXRs: a new class of oxysterol receptors. Curr. Opin. Genet. Dev. 1998, 8:571-575.
2. Zelcer N., Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest. 2006, 116:607-614.
3. Wiebel F.F., Gustafsson J.A. Heterodimeric interaction between retinoid X receptor alpha and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activation. Mol. Cell Biol. 1997, 17:3977-3986.
4. Shulman A.I., Larson C., Mangelsdorf D.J., Ranganathan R. Structural determinants of allosteric ligand activation in RXR heterodimers. Cell 2004, 116:417-429.
5. Wiebel F.F., Steffensen K.R., Treuter E., Feltkamp D., Gustafsson J.A. Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer. Mol. Endocrinol. 1999, 13:1105-1118.
6. McInerney E.M., et al. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev. 1998, 12:3357-3368.
7. Son Y.L., Park O.G., Kim G.S., Lee J.W., Lee Y.C. RXR heterodimerization allosterically activates LXR binding to the second NR box of activating signal co-integrator-2. Biochem. J. 2008, 410:319-330.
8. Son Y.L., Lee Y.C. Molecular determinants of the interactions between LXR/RXR heterodimers and TRAP220. Biochem. Biophys. Res. Commun. 2009, 384:389-393.
9. Kim J.Y., Park O.G., Lee J.W., Lee Y.C. One- plus two-hybrid system, a novel yeast genetic selection for specific missense mutations disrupting protein/protein interactions. Mol. Cell Proteomics 2007, 6:1727-1740.
10. Rosenfeld M.G., Lunyak V.V., Glass C.K. Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev. 2006, 20:1405-1428.
11. Pogenberg V., et al. Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. J. Biol. Chem. 2005, 280:1625-1633.